Angiocentric and Angiodestructive Infiltration of Adult T-Cell Leukemia/Lymphoma (ATLL) in the Skin

Manabe, Toshiaki; Hirokawa, Mitsuyoshi; Sugihara, Keiko; Sugihara, Takashi; Kohda, Mamoru

doi:10.1097/00000372-198812000-00003

Cited by 34 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we consider that the disease in this case must be very closely related to angiocentric lymphoma, because the clinical course was severe and acute, taking only 10 months from onset to death. To our knowledge, the present case is the sixth reported lymphoma with angiocentric and angiodestructive features associated with HTLV-l infection (5)(6)(7).…”

Section: Discussionmentioning

confidence: 77%

A Case of Adult T‐cell Leukemia/Lymphoma (ATLL) with Angiocentric and Angiodestructive Features

Ohtake

Setoyama

Fukumaru

et al. 1997

The Journal of Dermatology

View full text Add to dashboard Cite

This report describes a case of adult T-cell leukemia/lymphoma (ATLL) with angiocentric and angiodestructive features. The patient was a 66-year-old Japanese woman who began developing widespread skin lesions ten months prior to admission. The diagnosis of ATLL was made on the basis of her having an antibody to human T-cell lymphotropic virus type-1 (HTLV-1) and typical flower cells (ATLL cells) in peripheral blood smears. Once hospitalized, the course of her disease was very acute and severe, as is seen with angiocentric lymphoma. Based on histological features, this case was judged not to be angiocentric lymphoma; however, it may lie within the spectrum of angiocentric immunoproliferative lesions (AIL). The findings in this case strongly suggest that HTLV-1 can be a pathogenic factor in the expression of angiocentric and angiodestructive features in ATLL, as is Epstein-Barr virus (EBV) (1-4). To our knowledge the present case is the sixth reported in the literature of lymphoma in which these features are associated with HTLV-1 infection (5-7).

show abstract

Section: Discussionmentioning

confidence: 77%

A Case of Adult T‐cell Leukemia/Lymphoma (ATLL) with Angiocentric and Angiodestructive Features

Ohtake

Setoyama

Fukumaru

et al. 1997

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…[192021222324] Author has reported the unusual presentation of verrucous papules, umbilicated papules, and mucosal lesions in ATL. [25]…”

Section: Discussionmentioning

confidence: 99%

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

et al. 2016

View full text Add to dashboard Cite

Background:Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.Aim:To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patientsMaterials and Methods:This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining.Results:Among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.5:1. The most common types of T-cell lymphomas included mycosis fungoides (MF) (57.1%) followed by adult T-cell lymphoma/leukemia (ATL) (17.1%). Primary cutaneous peripheral T-cell lymphoma not otherwise specified was diagnosed in 17.1% and anaplastic large cell lymphoma in 2.9%. The morphological types of MF included polymorphic, poikilodermatous, folliculotropic, hypopigmented, hyperpigmented, mixed, and purpuric. Skin manifestations of ATL included ulcerated plaques and erythroderma. Epidermotropism was very marked in ATL (83.3%) than in MF (70%). Larger Pautrier's microabscess was noted in ATL compared to smaller ones in MF. Markedly dense, diffuse infiltrate of atypical cells was noted in ATL in contrast to mild to moderate nodular or perivascular infiltrate in MF. ATL had an extremely poor prognosis.Limitations:Identification of DNA integration of HTLV-1 by Southern blot could not be analyzed, and the number of cases studied is limited.Conclusions:The study showed unique patterns of subtypes of cutaneous lymphomas in our country. Variations in the clinical pattern and histopathological analysis will help to differentiate T-cell lymphoma types which have prognostic implications.

show abstract

“…9.5). Variants of ATLL with angiocentricity and/or angiodestruction or with bullous lesions have been observed [14,15]. Variants of ATLL with angiocentricity and/or angiodestruction or with bullous lesions have been observed [14,15].…”

Section: Histopathology Immunophenotype and Molecular Geneticsmentioning

confidence: 99%

Cutaneous Adult T‐Cell Leukemia/Lymphoma

2014

Skin Lymphoma

View full text Add to dashboard Cite

Angiocentric and Angiodestructive Infiltration of Adult T-Cell Leukemia/Lymphoma (ATLL) in the Skin

Cited by 34 publications

References 0 publications

A Case of Adult T‐cell Leukemia/Lymphoma (ATLL) with Angiocentric and Angiodestructive Features

A Case of Adult T‐cell Leukemia/Lymphoma (ATLL) with Angiocentric and Angiodestructive Features

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

Cutaneous Adult T‐Cell Leukemia/Lymphoma

Contact Info

Product

Resources

About