Eight cases of patent ductus arteriosus associated with marked pulmonary hypertension are presented with complete cardiac catheterization studies in six patients and autopsy studies in three cases. Four patients had clear evidence of a "reversed" shunt through the ductus, three presenting the clinical picture of cyanotic congenital heart disease. The authors discuss the nature of the increase(l resistance of the pulmonar vascular bed which is the basis of the circulatory changes in these cases.T HE usual uncomplicated patent ductus arteriosus presents a fairly constant clinical picture with the following diagnostic features usually present: (1) a continuous murmur in the pulmonic area; (2)