Anginose Type of Infectious Mononucleosis Requiring Tracheostomy

Marfatia, P. T.

doi:10.1017/s0022215100069528

Cited by 8 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In typical cases, swallowing becomes painful but requires only conservative supportive measures, and spontaneous resolution occurs. Occasionally, however, pharyngitis can result in the inability of the patient to maintain adequate hydration, and in severe cases obstruction of the upper airway can result (Yeager 1964;Marfatia 1968;Simcock and Prout 1974;McCurdy 1975;GutsegeIl1971). This is usually due to inflammation, edema, and hypertrophy of lymphoid tissue in Waldeyer's ring.…”

Section: Pharyngeal Complicationsmentioning

confidence: 99%

Infectious Mononucleosis

1989

Clinical Topics in Infectious Disease

View full text Add to dashboard Cite

Infectious mononucleosis is a clinical entity characterized by pharyngitis, cervical lymph node enlargement, fatigue and fever, which results most often from a primary Epstein-Barr virus (EBV) infection. EBV, a lymphocrytovirus and a member of the γ-herpesvirus family, infects at least 90% of the population worldwide, the majority of whom have no recognizable illness. The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8 + T lymphocytes directed against EBV-infected B cells. During convalescence, CD8 + T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients especially young children. EBV-specific antibody profiles are the best choice for staging EBV infection. In addition to causing acute illness, long-term consequences are linked to infectious mononucleosis, especially Hodgkin lymphoma and multiple sclerosis. There is no licensed vaccine for prevention and no specific approved treatment. Future research goals are development of an EBV vaccine, understanding the risk factors for severity of the acute illness and likelihood of developing cancer or autoimmune diseases, and discovering anti-EBV drugs to treat infectious mononucleosis and other EBV-spurred diseases.

show abstract

Section: Pharyngeal Complicationsmentioning

confidence: 99%