Angina bullosa hemorrhagica: Report of two cases

Abstract

Angina bullosa hemorrhagic (ABH) describes the acute and sometimes painful onset of oral blood-filled vesicles and bullae, not attributable to blood dyscrasia, vesiculobullous disorders, systemic diseases or other known causes. The haemorrhagic bullae spontaneously burst after a short time resulting in ragged, often painless, superficial erosions that heal spontaneously within 1 week without scarring. Trauma appears to be the most common identifiable precipitating factor, but the essential tissue defect is yet unidentified. This paper presents two cases of ABH with the aim to create awareness regarding occurrence of this lesion, thus avoiding any misdiagnosis.

Is inhaled glucocorticoids the only culprit in angina bullosa hemorrhagica?

“…It has been suggested that a mechanical instability of the epithelial-connective tissue connection, which may induce a susceptibleness of the nonkeratinized mucosa to damage, is the primary pathogenetic mechanism in this disorder. [ 1 2 3 4 5 6 7 8 9 10 ] We also agree on these presumed etiological factors and suggest that an explanation lies in understanding the morphology and cellular dynamics of the human skin.…”

“…Awareness of this entity is very important to avoid misdiagnosis and unnecessary diagnostic procedures. [ 1 2 3 4 5 6 7 8 9 10 ] In our opinion, ABH is one of the most peculiar diseases of dermatology practice. This case report highlights the underlying pathophysiology and clinical presentation of ABH.…”

“…A unique feature of ABH is that the history of each occurrence is special and specific and identical for each patient. [ 1 2 3 4 5 6 7 8 9 10 ]…”

“…[ 1 2 3 4 5 6 7 8 9 10 ] It goes back to 1960s when Badram first described clinical features of this condition and coined the term “angina bullosa hemorrhagica.”[ 11 ] ABH is a rare dermatosis with limited available data in the literature. [ 1 2 3 4 5 6 7 8 9 10 11 ] Here, we report a case with ABH, who presents typical clinical characteristics of this entity. We not only highlight distinctive clinical features but also discuss the possible roles of inhaled glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSAIDs) in the pathogenesis of ABH.…”

Angina bullosa hemorrhagica

“…В сыворотке пациентов с АБГ при постановке реакции непрямой иммунофлюоресценции аутоантитела не выявляются [3]. Биопсия и иммунофлюоресцентная микроскопия могут быть полезными для исключения других буллезных заболеваний [20].…”