Anger Proneness Predicts Coronary Heart Disease Risk

Williams, Janice E.; Paton, Catherine; Siegler, I.; Eigenbrodt, Marsha L.; Nieto, F. Javier; Tyroler, H. A.

doi:10.1161/01.cir.101.17.2034

Cited by 227 publications

(55 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The pathogenesis of anger-related cardiac events implicates acute mental stress induced ischemia, coronary vasospasm, endothelial dysfunction in the setting of increased catecholamines, plaque instability, enhanced thrombogenicity, and arrhythmias. In the Atherosclerosis Risk in Communities (ARIC) study, those with normal BP prone to anger were at higher risk of acute MI, revascularization, and cardiac mortality compared to those with a low anger trait, although this association was not present in hypertensive patients 136 . In a case-crossover analysis in the Stockholm Heart Epidemiology Program (SHEEP) of women and men, anger was associated with an increased risk of MI up to one hour after an outburst of anger 137 .…”

Section: Non-framingham Risk Factorsmentioning

confidence: 99%

Ischemic heart disease in women: A focus on risk factors

Mehta

Wei

Wenger

2015

Trends in Cardiovascular Medicine

156

108

View full text Add to dashboard Cite

Heart disease remains a major contributor to morbidity and mortality in women in the United States and worldwide. This review highlights known and emerging risk factors for ischemic heart disease (IHD) in women. Traditional Framingham risk factors such as hypertension, hyperlipidemia, diabetes, smoking, as well as lifestyle habits such as unhealthy diet and sedentary lifestyle are all modifiable. Health care providers should be aware of emerging cardiac risk factors in women such as adverse pregnancy outcomes, systemic autoimmune disorders, obstructive sleep apnea, and radiation-induced heart disease; psychosocial factors such as mental stress, depression, anxiety, low socioeconomic status, and work and marital stress play an important role in IHD in women. Appropriate recognition and management of an array of risk factors is imperative given the growing burden of IHD and need to deliver cost-effective, quality care for women.

show abstract

Section: Non-framingham Risk Factorsmentioning

confidence: 99%

Ischemic heart disease in women: A focus on risk factors

Mehta

Wei

Wenger

2015

Trends in Cardiovascular Medicine

156

108

View full text Add to dashboard Cite

show abstract

“…8 In the Atherosclerosis Risk in Communities Study, angry feelings predicted CHD but only among normotensives. 9 Finally, clinical ratings of overall potential for hostility based on behaviors displayed during a semistructured interview predicted a combined index of nonfatal MI (nϭ130) and CHD death (nϭ62) among high-risk men during the 7 years of the active phase of the Multiple Risk Factor Intervention Trial (MRFIT 10 ).…”

mentioning

confidence: 99%

Hostile Behaviors Predict Cardiovascular Mortality Among Men Enrolled in the Multiple Risk Factor Intervention Trial

et al. 2004

View full text Add to dashboard Cite

Background-Hostility is associated with incident coronary disease in most large population-based studies, but little is known about its association with cardiovascular disease (CVD) mortality in high-risk individuals. The aim of this study was to assess the association of hostility with CVD mortality in the subsequent 16 years in the Multiple Risk Factor Intervention Trial (MRFIT) participants and to explore the influence of hostility in the subset that had a nonfatal CVD event during the trial. Methods and Results-We coded the Structured Interview responses of 259 men who died of CVD during the 16 years of follow-up and 259 matching living control subjects. Signs of hostility were assessed by use of the Interpersonal Hostility Assessment Technique. Matching was based on center, intervention group, age, race, and interviewer; covariates included study entry diastolic blood pressure, cholesterol, smoking status, and nonfatal CVD event during the trial. High-hostile men were more likely to die of CVD than were low-hostile men. Adjusted odds ratio (OR) and 95% confidence intervals (CIs) were 1.61, 1.09 to 2.39. After the trial, high-hostile men who also had a nonfatal event during the trial were particularly likely to die of CVD, OR, 5.06, 1.42 to 8.22, compared with low-hostile men without a nonfatal event during the trial. Conclusions-Hostility may be a risk factor for CVD mortality among high-risk men. Interventions aimed at anger management and stress reduction along with risk factor modification may be useful for hostile patients.

show abstract

“…The 10-item Spielberger Trait Anger Scale (STAS) [27,28] was used to assess, in the same session, the frequency and degree to which each participant had anger and aggressive behavior (AB). For each question, patients were asked to use a numerical scale (1 = almost never, 2 = sometimes, 3 = often, and 4 = almost always) to best represent their post-stroke status.…”

Section: Methodsmentioning

confidence: 99%

Serotonergic Correlation with Anger and Aggressive Behavior in Acute Stroke Patients: An Intensity Dependence of Auditory Evoked Potentials (IDAP) Study

et al. 2014

View full text Add to dashboard Cite

Anger and aggressive behavior (AB) are two of the main post-stroke behavioral manifestations, which could imply both an anger trait (TA) or a state condition of anger (SA). Serotonergic system is thought to play an inhibitory control on aggressive impulse. Nevertheless, whether 5HT has the same role in TA and in SA, is still debated. Intensity dependence of auditory evoked potentials (IDAP) is thought to be inversely related to the central 5HT tone. The aim of this study was to evaluate, in acute stroke patients, the 5HT system involvement in AB by IDAP. Consecutive stroke patients were evaluated and compared with healthy controls. The Spielberger Trait Anger Scale (STAS) was used to assess AB, SA and TA. Patients with AB and TA showed a significantly increased IDAP value, whereas patients with SA had a significantly lower IDAP; this indicates an increased 5HT tone. In acute stroke patients with AB, there is a decreased central 5HT tone. Surprisingly, we found an opposite 5HT feature between patients with TA and those showing SA, suggesting that the hypothesis of aggression based on 5HT deficiency requires further investigations. This might open new strategies in the treatment of post-stroke AB.

show abstract

Anger Proneness Predicts Coronary Heart Disease Risk

Cited by 227 publications

References 32 publications

Ischemic heart disease in women: A focus on risk factors

Ischemic heart disease in women: A focus on risk factors

Hostile Behaviors Predict Cardiovascular Mortality Among Men Enrolled in the Multiple Risk Factor Intervention Trial

Serotonergic Correlation with Anger and Aggressive Behavior in Acute Stroke Patients: An Intensity Dependence of Auditory Evoked Potentials (IDAP) Study

Contact Info

Product

Resources

About