Anger Experiences Among Hepatitis C Patients: Relationship to Depressive Symptoms and Health-Related Quality of Life

Dan, Adrian G.; Crone, Cathy; Wise, Thomas N.; Martin, Lisa M.; Ramsey, Lolita; Magee, Scarlett; Sjogren, Robert W.; Ong, Janus P.; Younossi, Zobair M.

doi:10.1176/appi.psy.48.3.223

Cited by 37 publications

(30 citation statements)

References 20 publications

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“…Studies in Parkinson's disease have demonstrated that both objective cognitive deficits [13] and self-rated cognitive function [14] are associated with QOL. Similarly, although anger has not been studied in dystonia, there is evidence from other patient populations that anger may be associated with a worse QOL and depression [7,12]. From this dataset we cannot determine whether these emotional symptoms are secondary to pain or chronic illness or primary manifestations of dystonia.…”

Section: Discussionmentioning

confidence: 99%

Mood and energy determinants of quality of life in dystonia

et al. 2009

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Prior research has demonstrated that dystonia patients may have reductions in numerous measures of quality of life (QOL) when compared to healthy age-matched controls. However, the determinants of QOL in this patient population have not been fully specified. To address this issue, we administered the Medical Outcomes Study Short Form 36 (SF-36) questionnaire along with the Visual Analogue Mood Scale (VAMS), the Beck Depression Inventory (BDI), the Unified Dystonia Rating Scale (UDRS), and the State and Trait Anxiety Index (STAI) to 73 patients diagnosed with primary dystonia. Dystonia patients demonstrated lower QOL on all subscales of the SF-36 compared to normative healthy age-matched data. While the UDRS, a predominantly motor scale, was not significantly correlated with QOL (r = -0.19, P = 0.11), the BDI (r = -0.79, P < 0.0001), the STAI (r = -0.63, P < 0.0001) and multiple subscales of the VAMS revealed significant correlations. The tired subscale was the item most strongly correlated with overall QOL (r = -0.52, P < 0.0001), and particularly QOL related to physical function. The association of tiredness with QOL remained significant even when adjusting for the BDI and STAI scores (P < 0.0001). This study highlights the importance of mood and energy in QOL among a cohort of patients with dystonia. Further studies will be needed to determine the effect of treatment on these associations and whether disturbances in energy are related to sleep disturbances or to primary fatigue issues.

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Section: Discussionmentioning

confidence: 99%

Mood and energy determinants of quality of life in dystonia

et al. 2009

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“…Irritability has long been known as a side effect of interferon treatment for hepatitis (Bezemer et al, 2012;Blacklaws et al, 2009Blacklaws et al, , 2011Constant et al, 2005;Dan et al, 2007;Giunta et al, 2007;Kraus et al, 2002Kraus et al, , 2003Kraus et al, , 2005Kronenberger et al, 2007;Maddock et al, 2004;Préau et al, 2008;Russo et al, 2005). There is evidence that immunological processes mediate this side effect.…”

Section: Irritability and Inflammationmentioning

confidence: 99%

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

Rathbone

Tharmaradinam

Jiang

et al. 2015

Brain, Behavior, and Immunity

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“…In addition to clinical outcomes, investigators have confirmed that HCV infection causes a tremendous impact on PROs [64][65][66][67][68][69][70][71][72][73]. PROs are defined as measurements of a patient's state of health as perceived by the patient and are reported directly from the patient without any modification [74].…”

Section: Patient Reported Outcomes Related To Hcv Infectionmentioning

confidence: 99%

“…Therefore, through the use of PRO instruments, clinical investigators have been able to establish that patients with HCV infection experience tremendous impairment in their health related quality of life (HRQOL) and well-being, especially in the domains of physical functioning, mental health, and work productivity as a result of the virus itself [64][65][66][67][68][69][70][71][72][73][75][76][77][78][79][80]. Additionally, multivariate analyses have determined that disease severity (presence of advanced liver disease), and psychiatric co-morbidities, especially depression, are important drivers of PRO impairment [67,75,76,78].…”

Section: Patient Reported Outcomes Related To Hcv Infectionmentioning

confidence: 99%

“…Additionally, multivariate analyses have determined that disease severity (presence of advanced liver disease), and psychiatric co-morbidities, especially depression, are important drivers of PRO impairment [67,75,76,78]. It is important to recognize that, in a similar fashion that the clinical outcomes are considered the surrogate markers of survival, and PROs are important surrogate markers of patient experience [81].…”

Section: Patient Reported Outcomes Related To Hcv Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis C infection: A multi-faceted systemic disease with clinical, patient reported and economic consequences

Younossi

Birerdinc

Henry

2016

Journal of Hepatology

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Hepatitis C virus infection (HCV) affects approximately 170-200 million individuals globally. HCV is one of the primary causes of hepatocellular carcinoma (HCC) and cirrhosis and has been identified as the leading indication for liver transplantation in most Western countries. Because HCV is a systemic disease with hepatic, extrahepatic, economic and patient reported consequences, it is important for healthcare practitioners to understand the comprehensive and multi-faceted picture of this disease. In this context, it is important to fully appreciate the impact of HCV on the individual patient and the society. With the recent advent of the new generation of direct antiviral agents, the long standing goal of eradicating HCV in most infected patients has been accomplished. Therefore, now more than ever, it is critical to assess the total benefits of sustained virological response in a comprehensive manner. This should not be limited to the clinical benefits of HCV cure, but also to account for the improvement of patient reported health and economic outcomes of HCV cure. It is only through this comprehensive approach to HCV and its treatment that we will understand the full impact of this disease and the tremendous gains that have been achieved with the new antiviral regimens.

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Anger Experiences Among Hepatitis C Patients: Relationship to Depressive Symptoms and Health-Related Quality of Life

Cited by 37 publications

References 20 publications

Mood and energy determinants of quality of life in dystonia

Mood and energy determinants of quality of life in dystonia

A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS

Hepatitis C infection: A multi-faceted systemic disease with clinical, patient reported and economic consequences

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