Angelica sinensis polysaccharides ameliorate 5-flourouracil-induced bone marrow stromal cell proliferation inhibition via regulating Wnt/β-catenin signaling

Xiao, Hanxianzhi; QI, RONGJIA; WANG, ZILING; Xiao, Minghe; Xiang, Yue; WANG, YAPING; WANG, LU

doi:10.32604/biocell.2021.015039

Cited by 4 publications

(3 citation statements)

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“…Dong Quai is supposed to strengthen bones by stimulating bone cells to form bones, as well as by preventing bone loss. An in vitro study published in 2002 concluded the bone reformation effect of Dong Quai on human bone cells where its extract was used on osteoblast precursor cells, stimulated bone remodeling by increasing the secretion of protein and synthesis of bone collagen (Xiao et al, 2021; Q. Yang et al, 2002). In another study conducted on mice, administering ferulic acid, a natural compound extracted from Dong Quai roots, was shown to improve bone mineral content, and density, and activate bone cell growth.…”

Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

“…Quai is supposed to strengthen bones by stimulating bone cells to form bones, as well as by preventing bone loss. An in vitro study published in 2002 concluded the bone reformation effect of Dong Quai on human bone cells where its extract was used on osteoblast precursor cells, stimulated bone remodeling by increasing the secretion of protein and synthesis of bone collagen(Xiao et al, 2021; …”

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confidence: 99%

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Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

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Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

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Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

mentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Polysaccharides can activate T cells ( An et al, 2022 ), B cells ( Xiao et al, 2023 ) and macrophages ( Tabarsa et al, 2022 ), modulating the body's immune response. Recent studies have revealed the potential of polysaccharides as immune adjuvants, enhancing both specific and non-specific immune responses when combined with vaccines ( Smith et al, 2023 ; Zhao et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%