Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila

Tuo, Wenjuan; Wang, Shuwei; Shi, Yan; Cao, Wangjie; Liu, Yongqi; Su, Yun; Xiu, Minghui; He, Jianzheng

doi:10.1016/j.ijbiomac.2023.124639

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…Neutral polysaccharides from Rehmannia glutinosa were found to be a functional pharmaceutical ingredient to increase stress resistance and extend the life of C. elegans via the IIS [ 8 ]. The other finding [ 9 ] showed that Angelica sinensis polysaccharides remarkably extended lifespan, increased reproduction, improved climbing ability, and increased resistance to starvation and oxidative stress in aged flies, mainly via inhibiting IIS and TOR signaling and boosting antioxidant ability. Using the mouse as a model organism, Li et al demonstrated that the Hizikia fusiforme polyphenol–polysaccharide complex has potential in the development of natural anti-aging drugs [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Aging in Caenorhabditis elegans of Polysaccharides from Polygonatum cyrtonema Hua

Zhang,

Chen,

Chen

et al. 2024

Molecules

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Polygonatum cyrtonema Hua, the dried rhizome of Polygonum multiflorum from the Liliaceae family, is a widely used medicinal herb with a long history of application. Its main active ingredients are polysaccharides, which have been demonstrated in contemporary studies to effectively delay the aging process. In the present study, homogeneous polysaccharide (PCP-1) was obtained after the purification and isolation of polysaccharides from Polygonatum cyrtonema Hua (PCP). The anti-aging activities of both were compared, and the possible mechanism of action for exerting anti-aging activity was explored using Caenorhabditis elegans (C. elegans). Research has indicated that PCP and PCP-1 exhibit potent anti-oxidant and anti-aging properties. Of particular note is that PCP-1 acts better than PCP. The two were able to prolong the lifespan of nematodes, improve the stress resistance of nematodes, reduce the accumulation of lipofuscin in the intestine, decrease the content of ROS and MDA in the body, increase the activity of the antioxidant enzymes SOD and CAT, promote the nuclear translocation of DAF-16, down-regulate the mRNA levels of the age-1 and daf-2 genes of the IIS pathway in nematodes, and up-regulate the expression of the daf-16, skn-1, sod-3, and hsp-16.2 genes. Based on the aforementioned findings, it is possible that the mechanism by which PCP and PCP-1 exert anti-aging effects may be through negative regulation of the IIS pathway, activation of the transcription factor DAF-16/FOXO, and enhancement of oxidative defenses and stress resistance in nematodes. Overall, the present study illustrated the great potential of polysaccharides from Polygonatum cyrtonema Hua in anti-aging and antioxidant activities. Specifically, PCP-1 demonstrated superior characteristics, which provides a reference for the future development of Polygonatum cyrtonema Hua polysaccharides.

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Section: Introductionmentioning

confidence: 99%

Anti-Aging in Caenorhabditis elegans of Polysaccharides from Polygonatum cyrtonema Hua

Zhang,

Chen,

Chen

et al. 2024

Molecules

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“…TCM polysaccharide is an effective polysaccharide extracted from a single Chinese medicine by modern scientific and technological methods. It mainly consists of glucose (Glu), rhamnose (Rha), mannose (Man), galactose (Gal), xylose (Xyl), arabinose (Ara), ribose (Rib), fructose (Fru), sucrose (Suc), fucose (Fuc), and other monosaccharide components ( 14 , 15 ), which has anti-aging, anti-tumor, immune regulation and other functions ( 16 – 19 ). A large number of clinical trials and experimental studies have proved that some TCM polysaccharides (especially those extracted from the TCM with possible anti-tumor effect) have a certain function of regulating tumor immune response, with mild or no toxic and side effects at effective doses.…”

Section: Introductionmentioning

confidence: 99%

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder the immune response and lead to a state of immune suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. This review aims to look into the immunomodulatory effects of TCM polysaccharides on HCC. The immunomodulatory effects of TCM polysaccharides are primarily manifested through the activation of effector T lymphocytes, dendritic cells, NK cells, and macrophages against hepatocellular carcinoma (HCC) both in vivo and in vitro settings. Furthermore, TCM polysaccharides have demonstrated remarkable adjuvant antitumor immunomodulatory effects on HCC in clinical settings. Therefore, the utilization of TCM polysaccharides holds promising potential for the development of novel therapeutic agents or adjuvants with advantageous immunomodulatory properties for HCC.

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Irinotecan cause the side effects on development and adult physiology, and induces intestinal damage via innate immune response and oxidative damage in Drosophila

He,

Han,

Wang

et al. 2023

Biomedicine & Pharmacotherapy

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Angelica sinensis polysaccharide extends lifespan and ameliorates aging-related diseases via insulin and TOR signaling pathways, and antioxidant ability in Drosophila

Cited by 6 publications

References 72 publications

Anti-Aging in Caenorhabditis elegans of Polysaccharides from Polygonatum cyrtonema Hua

Anti-Aging in Caenorhabditis elegans of Polysaccharides from Polygonatum cyrtonema Hua

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Irinotecan cause the side effects on development and adult physiology, and induces intestinal damage via innate immune response and oxidative damage in Drosophila

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