Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice

Wang, Kaiping; Song, Zhizhen; Wang, Hongjing; Li, Qiang; Cui, Zheng; Zhang, Yu

doi:10.1016/j.intimp.2015.12.021

Cited by 72 publications

(52 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NF‐κB is considered as a pivotal transcription factor of the inflammatory response that is activated by many stimuli and participate in the regulation of hundreds of genes for different inflammatory cytokines such as TGF‐β1, TNF‐α and IL‐1 . Previous studies have focused on the central role of NF‐κB in the mediation of Con A‐induced hepatitis via the release of inflammatory cytokines . The results of the present study are in agreement with these reports as there was a significant elevation in NF‐κB expression in Con A group compared to the control one.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Pirfenidone ameliorates concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways

El‐Agamy

2016

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

“…Oxidative stress is a cornerstone in the pathophysiology various hepatic damages. Recent reports have demonstrated that ROS play a pivotal role in Con A‐induced hepatitis . The results of the present study revealed that Con A administration caused a marked elevation of lipid peroxidation as indicated by severe accumulation of MDA.…”

Section: Discussionsupporting

confidence: 64%

Pirfenidone ameliorates concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways

El‐Agamy

2016

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Specifically, ASP protects cultured neural cells from H 2 O 2 -induced cytotoxicity and reduces elevated intracellular ROS, but also prevents in vivo oxidative damage and ameliorates ischemic brain injury in rats [28]. It has also been showed that ASP attenuates concanavalin A-induced liver injury by decreasing ROS and increasing antioxidant enzyme activity [29]. …”

Section: Discussionmentioning

confidence: 99%

Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model

Zhang

et al. 2017

Stem Cells International

View full text Add to dashboard Cite

Age-related regression in hematopoietic stem/progenitor cells (HSC/HPCs) limits replenishment of the blood and immune system and hence contributes to hematopoietic diseases and declined immunity. In this study, we employed D-gal-induced aging mouse model and observed the antiaging effects of Angelica Sinensis Polysaccharide (ASP), a major active ingredient in dong quai (Chinese Angelica Sinensis), on the Sca-1+ HSC/HPCs in vivo. ASP treatment prevents HSC/HPCs senescence with decreased AGEs levels in the serum, reduced SA-β-Gal positive cells, and promoted CFU-Mix formation in the D-gal administrated mouse. We further found that multiple mechanisms were involved: (1) ASP treatment prevented oxidative damage as total antioxidant capacity was increased and levels of reactive oxygen species (ROS), 8-OHdG, and 4-HNE were declined, (2) ASP reduced the expression of γ-H2A.X which is a DNA double strand breaks (DSBs) marker and decreased the subsequent ectopic expressions of effectors in p16Ink4a-RB and p19Arf-p21Cip1/Waf senescent pathways, and (3) ASP inhibited the excessive activation of Wnt/β-catenin signaling in aged HSC/HPCs, as the expressions of β-catenin, phospho-GSK-3β, and TCF-4 were decreased, and the cyto-nuclear translocation of β-catenin was inhibited. Moreover, compared with the positive control of Vitamin E, ASP exhibited a better antiaging effect and a weaker antioxidation ability, suggesting a novel protective role of ASP in the hematopoietic system.

show abstract

“…Numerous reports have revealed potential therapeutic approaches to improve Con A-induced liver injury through suppression of oxidative stress and apoptotic cell death 34–36 . Our results indicated that the MDA level was significantly increased in the aged mice compared with that of the young mice, and a further elevation was observed in aged mice after Con A challenge (Fig.…”

Section: Resultsmentioning

confidence: 99%

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Huang

Chen

Liu³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Loss of regenerative capacity plays a critical role in age-related autoimmune hepatitis. Evidence implicates SIRT1 and p66shc in cell senescence, apoptosis, oxidative stress, and proliferation. This study investigated the effect of resveratrol on concanavalin A (Con A)-induced hepatitis in aged mice and the roles of SIRT1 and p66shc. Aged mice were administrated resveratrol (30 mg/kg orally) seven times at an interval of 12 h before a single intravenous injection of Con A (20 mg/kg). Results showed that the cytokines, TNF-α, IL-6, IFN-γ, and MCP-1, as well as infiltration of macrophages, neutrophils, and T lymphocytes in liver were dramatically enhanced in the mice given only Con A. The aged mouse livers showed markedly raised oxidative stress and cell apoptosis. This oxidative stress further aggravated regenerative dysfunction as indicated by the decreased levels of Ki67, PCNA, Cyclin D1, and Cdk2. Conversely, these phenomena were attenuated by pretreatment with resveratrol. Moreover, resveratrol suppressed the elevation of p66shc in the liver by reversing Con-A-mediated downregulation of SIRT1. The findings suggest that resveratrol protected against Con A-induced hepatitis in aged mice by attenuating an aberration of immune response and liver regeneration, partially via the mechanism of SIRT1-mediated repression of p66shc expression.

show abstract

Angelica sinensis polysaccharide attenuates concanavalin A-induced liver injury in mice

Cited by 72 publications

References 29 publications

Pirfenidone ameliorates concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways

Pirfenidone ameliorates concanavalin A-induced hepatitis in mice via modulation of reactive oxygen species/nuclear factor kappa B signalling pathways

Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

Contact Info

Product

Resources

About