Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway

Zou, Yuanfeng; Li, Cen-Yu; Fu, Yuping; JiZe, Xiao-Ping; Zhao, Yongfeng; Peng, Xi; Wang, Jingyi; Yin, Zhongqiong; Li, Yangping; Song, Xu; Li, Lixia; Zhao, Xinghong; Feng, Bin; Huang, Chao; Ye, Gang; Tang, Huaqiao; Chen, Ji; Li, Rui; Chen, Xingfu; Tian, Mengliang

doi:10.1016/j.ijbiomac.2023.124689

Cited by 10 publications

(2 citation statements)

References 70 publications

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“…Sun et al showed that LBP1C-2 extracted from Lycium barbarum was found to alleviate age-related bone loss by targeting BMPRIA/BMPRII/Noggin, which might serve as a new type of botanical medicine to fight age-related osteoporosis [ 45 ]. Several studies have demonstrated that Angelica sinensis could improve rheumatoid arthritis and colitis by reshaping the gut microbiota and also prevent splenic injury and functional impairment by inhibiting oxidative stress and cell apoptosis [ 12 , 46 , 47 ]. It also showed therapeutic potential in ischemic stroke treatment by regulating inflammation and autophagy pathways [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Tao,

Liao,

Zheng

et al. 2023

Nutrients

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The aim of this study was to explore whether drinking herbal tea and tea would positively benefit activities of daily living (ADL) in the elderly. We used data from the Chinese longitudinal healthy longevity survey (CLHLS) to explore the association. Drinking herbal tea and drinking tea were divided into three groups using latent class analysis (LCA): frequently, occasionally, and rarely. ADL disability was measured by the ADL score. Multivariate COX proportional hazards models with competing risks were used to explore the impact of drinking herbal tea and tea on ADL disability, statistically adjusted for a range of potential confounders. A total of 7441 participants (mean age 81.8 years) were included in this study. The proportions of frequently and occasionally drinking herbal tea were 12.0% and 25.7%, respectively. Additionally, 29.6% and 28.2% of participants reported drinking tea, respectively. Multivariate COX regression showed that compared with rarely drinking, frequently drinking herbal tea could effectively reduce the incidence of ADL disability (HR = 0.85, 95% CI = 0.77–0.93, p = 0.005), whereas tea drinking had a relatively weaker effect (HR = 0.92, 95% CI = 0.83–0.99, p = 0.040). Subgroup analysis found that frequently drinking herbal tea was more protective for males under 80 years old (HR = 0.74 and 0.79, respectively), while frequently drinking tea was somewhat protective for women (HR = 0.92). The results indicate that drinking herbal tea and tea may be associated with a lower incidence of ADL disability. However, the risks associated with using Chinese herb plants still deserve attention.

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Section: Discussionmentioning

confidence: 99%

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Tao,

Liao,

Zheng

et al. 2023

Nutrients

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“…NF-κB, an important transcription factor, plays a vital role in promoting the progress of IBD, which is usually activated in IBD and further increases the generation of inflammatory cytokines. 184 Therefore, inhibiting NF-κB pathway by natural products may be a promising approach to treating IBD, details in Table 3 .…”

Section: Ibd Treatments: Based On Experimentsmentioning

confidence: 99%

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Bai,

Wang,

et al. 2024

Science Progress

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Inflammatory bowel disease (IBD) is a chronic inflammatory disease with increasing incidence, such as Crohn's disease and ulcerative colitis. The accurate etiology and pathogenesis of IBD remain unclear, and it is generally believed that it is related to genetic susceptibility, gut microbiota, environmental factors, immunological abnormalities, and potentially other factors. Currently, the mainstream therapeutic drugs are amino salicylic acid agents, corticosteroids, immunomodulators, and biological agents, but the remission rates do not surpass 30–60% of patients in a real-life setting. As a consequence, there are many studies focusing on emerging drugs and bioactive ingredients that have higher efficacy and long-term safety for achieving complete deep healing. This article begins with a review of the latest, systematic, and credible summaries of the pathogenesis of IBD. In addition, we provide a summary of the current treatments and drugs for IBD. Finally, we focus on the therapeutic effects of emerging drugs such as microRNAs and lncRNAs, nanoparticles-mediated drugs and natural products on IBD and their mechanisms of action.

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An in-depth review: Unraveling the extraction, structure, bio-functionalities, target molecules, and applications of pectic polysaccharides

Pang,

Peng,

Ding

2024

Carbohydrate Polymers

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Angelica sinensis aboveground part polysaccharide and its metabolite 5-MT ameliorate colitis via modulating gut microbiota and TLR4/MyD88/NF-κB pathway

Cited by 10 publications

References 70 publications

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Association of Drinking Herbal Tea with Activities of Daily Living among Elderly: A Latent Class Analysis

Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

An in-depth review: Unraveling the extraction, structure, bio-functionalities, target molecules, and applications of pectic polysaccharides

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