Anévrysmes pulmonaires bilatéraux à issue fatale au cours de la maladie de Behçet

Bouomrani, Salem; Baïli, Hassène; Béji, M.

doi:10.13070/rs.fr.3.1545

Cited by 1 publication

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“…Various systemic visceral disorders (cardiovascular, neurological, gastrointestinal, renal, pulmonary, ocular, ...) can be seen during the evolution of this disease,and be potentially fatal [3]. Some of these serious disorders require the use of immunosuppressive treatments including ciclosporin A [4], a treatment that is not without sometimes severe adverse effects [5,6].…”

Section: Introductionmentioning

confidence: 99%

Acute interstitial nephritis due to Ciclosporin a toxicity during Behçet's disease

S¹,

Regaïeg²,

Nefoussi³

et al. 2019

Med Case Rep Rev

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Introduction: Ciclosporin A is an immunosuppressive molecule widely used in Behçet's disease (BD), especially for severe ocular and/or neurological disorders. Its particular toxicity in this field has, however, largely limited its use during this vasculitis. We report an aspect.Case report: 26-year-old patient followed since the age of 20 for BD with severe ocular involvement (bilateral posterior steroid-resistant uveitis with a significant decrease in visual acuity) requiring treatment with Ciclosporin A at a dose of 5mg/kg/twice daily during the first month and then 5mg/kg/day as a maintenance dose to control uveitis. The one-year control report noted a creatinine at 147μmol/l with aseptic leucocyturia at 400 elements/l. blood pressure was normal and there was no associated hematuria or proteinuria. The infectious and toxic investigation was normal. The ultrasound showed two kidneys of normal size and echo-structure. Renal biopsy revealed acute interstitial nephritis with images of toxic tubular necrosis. Cyclosporine was discontinued and replaced with azathioprine. Renal function normalized three weeks after stopping the molecule. Conclusion:periodic and regular monitoring of renal function (blood and urine tests) is strongly recommended in order to detect renal damage early in the BD; especially if Ciclosporin A treatment.

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Section: Introductionmentioning

confidence: 99%