Aneurysms of the carotid arteries associated with von Recklinghausen's neurofibromatosis

Giant Extracranial Aneurysms of Both Internal Carotid Arteries with Aberrant Jugular Veins in a Patient with Neurofibromatosis Type 1

“…1,2 Although NF-1 is defined by neurocutaneous findings, severe abnormalities of bone, 1 arteries, 2,3 and veins 4 have been noted. We describe a 28-year-old patient with bilateral giant extracranial aneurysms of the internal carotid arteries (ICAs), skull base meningoceles involving the jugular foramina, and aberrant jugular veins, who was treated successfully: After obtaining detailed imaging studies, we sacrificed her left ICA and used intravascular trapping with MicroCoils (MicroCoil System; Micrus, San Jose, Calif) in the right ICA and an endoluminal stent graft in the right external carotid artery (ECA) to bridge the orifice of the right ICA and exclude internal carotid flow.…”

“…Case reports on vascular anomalies have described severe intracranial and extracranial abnormalities involving arteries and occasionally, veins, often in combination and life-threatening in nature. 2,3,[7][8][9][10] Sometimes vascular lesions are clearly related to neurofibromas. Either vessels within the neurofibroma are anomalous or a neurofibroma compresses or infiltrates adjacent blood vessels.…”

“…Our patient, a 28-year-old woman, had bilateral giant extracranial aneurysms of the internal carotid arteries as well as skull base meningoceles involving the jugular foramina and aberrant jugular veins. CT and MR imaging, as well as digital subtraction and/or other angiography techniques, may be required to clarify pathology in patients with suggested vascular lesions.T he autosomal dominant mutation underlying neurofibromatosis type 1 (NF-1) has a very high prevalence, affecting 1 in 3000 Americans.1,2 Although NF-1 is defined by neurocutaneous findings, severe abnormalities of bone, 1 arteries, 2,3 and veins 4 have been noted. We describe a 28-year-old patient with bilateral giant extracranial aneurysms of the internal carotid arteries (ICAs), skull base meningoceles involving the jugular foramina, and aberrant jugular veins, who was treated successfully: After obtaining detailed imaging studies, we sacrificed her left ICA and used intravascular trapping with MicroCoils (MicroCoil System; Micrus, San Jose, Calif) in the right ICA and an endoluminal stent graft in the right external carotid artery (ECA) to bridge the orifice of the right ICA and exclude internal carotid flow.…”

Neurofibromatosis Type 1: From Presentation and Diagnosis to Vascular and Endovascular Therapy

“…57 A strong association among NF-1, abdominal aortic coarctation, 1-12,14,16-18,24,52-56 and/or renal ostial stenosis has been reported. [1][2][3][4][5][7][8][9][10][11][13][14][15][16][17][18]24,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] Stenoses/aneurysms have been identified also in the visceral, 10,16-19,24,61,71-73 coronary, 23,57 and cerebrovascular circulations 10,28,32,33,[58][59][60] in addition to the thoracic aorta and the subclavian and innominate arteries (see Table 2). 9,25,28,56,…”

Rupture of a Left Internal Jugular Vein

“…Other less frequent but severe forms of the disease involving the bones 3 , arteries and veins have been described 4,5 . Though NF-1 is rarely associated with spontaneous hemorrhage, this complication is thought to result from vasculature friability secondary to arterial dysplasia or vascular wall invasion by an adjacent nodule; gastrointestinal tract bleeding is usually caused by mucosal hypervascular plexiform neurofibromas 2 .…”