Aneurysmal Bone Cysts of the Craniofacial Origin: A Systematic Review

Rehman, Rafey; Dekhou, Antonio; Osto, Muhammad; Agemy, Jacob; Chaaban, Amneah; Yuhan, Brian; Thorpe, Eric

doi:10.1177/2473974x211052950

Cited by 7 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After a 6-month follow-up, there has been no recurrence. The reported recurrence rate for ABC ranges from 10% to 50% [20], although there are no reports about the recurrence of secondary ABCs only. In our case, the patient was 26 years old.…”

Section: Discussionmentioning

confidence: 99%

Aneurysmal bone cyst arising from the surgically removed craniofacial fibrous dysplasia in the long-term follow-up: a case report

Baek,

Kim

2023

Arch Craniofac Surg

View full text Add to dashboard Cite

Fibrous dysplasia (FD) is a rare skeletal disorder characterized by abnormal fibro-osseous connective tissue replacing normal bone. Despite its benign behavior, craniofacial FD can cause morphological disfigurement, headache, and even blindness as a result of the produced mass effect. Surgical resection is recommended when the patient shows apparent clinical symptoms or aggravating facial asymmetry. Postoperative complications have been reported, such as hematoma, surgical site infection, abscess formation, resorption of the bone graft used for reconstruction, and recurrence. An aneurysmal bone cyst (ABC) is a rare benign bony lesion that can occur secondary to preexisting bone tumor. Secondary ABCs in craniofacial FD are extremely rare in the literature, accounting for less than 30, all of which are either case reports or series. We report an extremely rare case of symptomatic secondary ABC arising from craniofacial FD that had been misdiagnosed with abscess formation or recurrence and was surgically removed. Notably, 17 years elapsed between the primary surgery and the complication of secondary ABC. The patient underwent total removal of secondary ABC. After surgery, symptoms were relieved, with no recurrence observed during a 6-month follow-up.

show abstract

Section: Discussionmentioning

confidence: 99%

Aneurysmal bone cyst arising from the surgically removed craniofacial fibrous dysplasia in the long-term follow-up: a case report

Baek,

Kim

2023

Arch Craniofac Surg

View full text Add to dashboard Cite

show abstract

“…Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls. 13,20,21 Further studies in aneurysmal bone cysts should examine different molecular pathways and proteins. Why USP-6 translocation is lower in the jaw than in the long tubular bone remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls 13,20,21 …”

Section: Discussionmentioning

confidence: 99%

Frequency of translocation of USP‐6 in the aneurysmal bone cyst of the jaw

Obermeier¹,

Schmöckel²,

Otto³

et al. 2022

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background This study aims to detect USP6 translocation in aneurysmal cysts located in the jaw and to give an overview of demographic data. Methods The present retrospective cohort study includes 10 patients who underwent surgery due to an aneurysmal cyst of the jaw in our hospital between 2002 and 2021. Unstained formalin‐fixed and paraffin‐embedded tissue sections cut at 4 μm thickness were subjected to USP6 FISH testing. Results All patients underwent surgical treatment. In four of ten patients (40%) USP‐6‐translocations have been found. Conclusion Based on the study, it is hypothesized that the aneurysmal bone cyst of the jaw bone may be subject to a different pathomechanism than that of the long bones. Therefore, it seems conceivable that the primary cause of aneurysmal bone cysts in the jaw might differ.

show abstract

“…All patients underwent surgical resection, with 1 patient requiring adjuvant radiation in addition to surgery. In total, 121 patients were disease-free and symptom-free with no evidence of recurrence (17.4 months median follow-up, 5.4 months median time to the first recurrence) [27].…”

Section: Vol 3 Suppl 6 Year 2022mentioning

confidence: 99%

Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review

Vasconcelos¹,

Bannak²,

Naves³

et al. 2022

MedNEXT

View full text Add to dashboard Cite

Introduction: Aneurysmal bone cysts (ABC) are pseudocysts expansive lesions. The World Health Organization (WHO) categorizes primary ABCs as cystic neoplasms that contain fibrous septa separating numerous blood-filled spaces. Approximately 70% of ABC cases are primary, while 30% are secondary. Objective: The present study aimed to carry out a concise systematic review of the main clinical findings of aneurysmal bone cysts, highlighting the incidence and prevalence, as well as the main forms of treatment. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from May 2022 to July 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 143 articles were found. In total, 73 articles were evaluated and 10 were included and evaluated in the systematic review. The symmetric funnel plot does not suggest a risk of bias. After prospecting the main literary findings, it was generally evidenced that the aneurysmal bone cyst (ABC) is a rare lesion that is more frequently found in young adults and children. It may have unpredictable behavior, with a high recurrence rate after treatment. Standard treatment consists of curettage plus local adjuvants and bone grafting to fill the void. In anatomic sites with difficult surgical access, percutaneous procedures are used (injection of sclerosing agents, radiofrequency thermal ablation, or selective arterial embolization. Medical management with bisphosphonates or denosumab has also been advocated. Conclusion: Primary ABCs involving the maxillofacial region are extremely rare and even more in patients with advanced age. Next-generation sequencing confirmed the presence of a USP6-CDH11 fusion gene, consistent with classification as a primary aneurysmal bone cyst. Sclerotherapy provided an effective and minimally invasive treatment for aneurysmal bone cysts and is particularly useful for deep injuries, challenging surgical access, and potentially injurious vital structures.

show abstract

Aneurysmal Bone Cysts of the Craniofacial Origin: A Systematic Review

Cited by 7 publications

References 26 publications

Aneurysmal bone cyst arising from the surgically removed craniofacial fibrous dysplasia in the long-term follow-up: a case report

Aneurysmal bone cyst arising from the surgically removed craniofacial fibrous dysplasia in the long-term follow-up: a case report

Frequency of translocation of USP‐6 in the aneurysmal bone cyst of the jaw

Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review

Contact Info

Product

Resources

About