Aneurysmal bone cysts of the spine

Zılelı, Mehmet; Işik, Hasan Serdar; Öğüt, Fatih; İş, Merih; Çağlı, Sedat; Çallı, Cem

doi:10.1007/s00586-012-2510-x

Cited by 95 publications

(72 citation statements)

References 27 publications

(47 reference statements)

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“…These researchers recommended complete resection and systematic RT for the treatment of aneurysmal bone cysts arising from giant cell tumors of the mobile spine because this combination provides good local tumor control. Other authors have drawn similar conclusions [64][65][66] . As complete and radical a procedure as possible should be performed in the first surgery.…”

Section: Postoperative Radiotherapysupporting

confidence: 69%

Surgery Combined with Radiotherapy to Treat Spinal Tumors: A Review of Published Reports

Bian

Chen

et al. 2016

Orthopaedic Surgery

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Spinal tumors result in high morbidity and a high rate of lower limb paralysis. Both surgical therapy and radiation therapy (RT) are used to treat spinal tumors; however, how best to combine these two therapies to maximize the benefits and minimize the risks is still being debated. It is also difficult to decide the optimal timing, course and dose of RT, especially in pregnant women and children. The aim of this review is to assist surgeons who are dealing with spinal tumors by providing comprehensive information about advanced techniques for administering RT with greater precision and safety, and about the impact of various ways of combining surgery and RT on therapeutic outcomes. We here review published reports about treating spinal tumors with a combination of these two forms of therapy and attempt to draw appropriate conclusions concerning selection of optimal treatment protocols. Our conclusion is that postoperative radiotherapy, especially with high-precision, low-dose and multiple fractions, and brachytherapy are promising therapies to combined with surgery.

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Section: Postoperative Radiotherapysupporting

confidence: 69%

Surgery Combined with Radiotherapy to Treat Spinal Tumors: A Review of Published Reports

Bian

Chen

et al. 2016

Orthopaedic Surgery

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“…An attempt at wide surgical resection may therefore lead only to intralesional curettage, with a risk of recurrence of 10-80 %, most often within the first 6-12 months after initial surgery [12,21]. Additional cavity filling with bone cement, using the heat to destroy residual cells, may reduce the risk of recurrence, but also carries a risk of causing irritation to neural structures.…”

Section: Discussionmentioning

confidence: 99%

Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts

et al. 2013

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Introduction Aneurysmal bone cysts (ABCs) are expansive and destructive lesions positive for osteoclast markers, resembling benign giant cell tumors (GCTs). Treatment options include surgical resection, curettage and cavity filling, embolization, injection of fibrosing agents, or radiotherapy. Particularly in children and adolescents with spinal ABCs, these options may be unsatisfactory, and innovative forms of treatment are needed. Denosumab is a human monoclonal antibody that inhibits osteoclast function by blocking the cytokine receptor activator of the nuclear factor-kappa B ligand. Satisfactory results with denosumab in treating GCTs and immunohistochemical similarities suggest that it may also have positive effects on ABCs. Methods and ResultsThis report is the first description of the therapeutic use of denosumab in two patients with spinal ABCs. Two boys (aged 8 and 11) had recurrent ABCs at C5 after surgery with intralesional tumor resection. Treatment options were discussed by the interdisciplinary tumor board. Arterial embolization was attempted, but failed due to an absence of appropriate afferent arteries. After the families had received extensive information and provided written consent, denosumab therapy was initiated as an individualized treatment, despite the absence as yet of scientific evidence. After the start of denosumab therapy, both patients recovered from pain and neurologic symptoms significantly and are now in a healthy condition with no severe side effects. Magnetic resonance imaging check-ups after 2 or 4 months of denosumab treatment, respectively, showed tumor regression in both patients. Discussion Longer follow-up and clinical studies are warranted to establish the value of denosumab in the treatment of ABCs.

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“…Fluid-fluid levels can be seen but not specific for ABCs. In one study, fluid-fluid levels were present only in half of cases30).…”

Section: Discussionmentioning

confidence: 91%

Cystic Giant Sacral Schwannoma Mimicking Aneurysmal Bone Cyst : A Case Report and Review of Literatures

Cho

Hur

Shim

et al. 2013

J Korean Neurosurg Soc

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To present a rare case of a cystic giant schwannoma of the sacrum mimicking aneurysmal bone cyst (ABC). A 54-year-old man visited our institute complaining left leg weakness and sensory change for several years. Magnetic resonance imaging revealed a large multilocular cystic mass with canal invasion and bone erosion confined to left S1 body. The lesion showed multiple septal enhancement without definite solid component. Initially the tumor was considered as ABC. The patient underwent grossly-total tumor resection with lumbosacral reconstruction via posterior approach. The tumor was proved to be a cystic schwannoma. The postoperative course was uneventful and the patient was relieved from preoperative symptoms. We present a rare case of pure cystic giant schwannoma confined to sacrum mimicking ABC. The surgical treatment is challenging due to the complex anatomy of the sacrum. Schwannoma should be considered in the differential diagnosis of osteolytic sacral cysts.

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Aneurysmal bone cysts of the spine

Cited by 95 publications

References 27 publications

Surgery Combined with Radiotherapy to Treat Spinal Tumors: A Review of Published Reports

Surgery Combined with Radiotherapy to Treat Spinal Tumors: A Review of Published Reports

Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts

Cystic Giant Sacral Schwannoma Mimicking Aneurysmal Bone Cyst : A Case Report and Review of Literatures

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