Aneuploidy rates are not higher in women with obesity: Is it worth the “weight” to delay in vitro fertilization until body mass index decreases?

HogenEsch, Elena; Boots, Christina E.; Bernardi, Lia A.

doi:10.1016/j.fertnstert.2021.06.004

Cited by 2 publications

(7 citation statements)

References 5 publications

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“…Physicians bear the responsibility to counsel patients with obesity on their lowered chances of success when undergoing fertility treatments. Given the metabolic intricacies of obesity, we must acknowledge that not all women with the equivalent BMIs will have the same reproductive potential [10]. Although BMI is a commonly used variable to assess overall health, reproductive outcomes are influenced by a multitude of factors beyond that.…”

Section: Discussionmentioning

confidence: 99%

“…Age outplays weight, thus delaying IVF in obese women may decrease overall IVF outcomes. Older obese women should consider undergoing embryo cryopreservation while working on improving their BMI [10]. With safety at the forefront, the focus should shift to achieving an optimal BMI prior to embryo transfer rather than oocyte retrieval in order to improve pregnancy outcomes, especially in women of advanced reproductive age.…”

Section: Effects Of Weight Loss On Reproductionmentioning

confidence: 99%

“…A prospective 2020 study evaluating 1706 obese women observed a lower ovarian reserve by AMH testing after adjusting for covariables such as age [9 ▪▪ ]. Theories behind decreased AMH production may be lipotoxic-induced apoptosis in granulosa cells, mitochondrial dysfunction and abnormalities in spindle structure leading to oocyte and follicle depletion [10,11].…”

Section: Obesity and Reproductive Physiologymentioning

confidence: 99%

“…These lower fertility rates are likely multifactorial involving anovulation, insulin resistance and alterations in gonadotropins. However, beyond true ovulatory dysfunction, the exact pathophysiology of how obesity decreases reproductive potential is unknown [10]. Large studies of over 7000 women have shown that fecundity is decreased in obese women with normal menstrual cycles [14 ▪▪ ].…”

Section: Fertility In Individuals With Obesitymentioning

confidence: 99%

“…Large studies of over 7000 women have shown that fecundity is decreased in obese women with normal menstrual cycles [14 ▪▪ ]. Excess adiposity leads to longer time to conception, decreased fecundity and live birth rates, and increased miscarriage [10]. Studies have shown that for every increase in BMI unit, the chance of spontaneous conception decreases by 5% in obese patients [15].…”

Section: Fertility In Individuals With Obesitymentioning

confidence: 99%

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Obesity and reproduction

Armstrong

Berger

Al-Safi

2022

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of reviewThe objective of this review is to highlight the recent literature on how obesity affects reproductive capacity in men and women. Recent findingsThe relationship between fertility and obesity is complex and involves the hypothalamic-pituitary-ovarian axis, neuroendocrine systems and adipose tissue. The exact pathophysiology of how obesity lowers fertility rates is unknown, but is likely multifactorial involving anovulation, insulin resistance and alterations in gonadotropins. In addition, there is controversy on whether oocyte quality or endometrial receptivity plays a larger role in obese infertile women. Data on effects of bariatric surgery and weight loss on obese infertile men and women are mixed. SummaryObesity alters the hormonal profile, gonadotropin secretion, embryo development and in-vitro fertilization outcomes in both men and women.

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Weight Loss On Reproductionmentioning

confidence: 99%

Section: Obesity and Reproductive Physiologymentioning

confidence: 99%

Section: Fertility In Individuals With Obesitymentioning

confidence: 99%

Section: Fertility In Individuals With Obesitymentioning

confidence: 99%

See 3 more Smart Citations

Obesity and reproduction

Armstrong

Berger

Al-Safi

2022

Current Opinion in Obstetrics &Amp; Gynecology

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A relationship between progesterone, maternal body weight, and offspring sex following the frozen/thawed single embryo transfer.

Ciepiela,

Czech,

Wójcik

et al. 2024

Preprint

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Background/Objectives: to investigate a possible relationship between women’s age, serum progesterone concentration (PRG), and body weight expressed by body mass index (BMI) on the day of embryo frozen/thawed transfer (FET), and the sex of the newborn baby. Subjects/Methods: A retrospective cohort study concerning children born after FET cycles conducted in one fertility clinic between January 2018 and September 2022. Out of 2,502 FET cycles, a group of 928 patients who underwent the transfer of the first best embryo from all frozen embryos, was extracted. All patients aged 23–46 qualified for FET during the study period were considered eligible. Cases where two embryos were transferred, and cycles where no data on progesterone concentration or embryos frozen at the cleavage stage were excluded from the study. Results: Odds ratio (OR) of maternal age (OR: 0.97; 95% CI: 0.94–1.00; p = 0.064), PRG (OR: 1.00; 95% CI: 0.77–1.30; p = 0.988), and BMI (OR: 1.01; 95% CI: 0.98–1.05; p = 0.478) were not found to be associated with childbirth. Moreover, the maternal age did not have a statistically significant effect on the likelihood of giving birth to a female child (OR: 0.99, 95% CI: 0.95–1.02; p = 0.495) or a male child (OR: 0.97, 95% CI: 0.94–1.01; p = 0.128). However, the study found that increased levels of PRG over 20 ng/ml (OR: 1.38, 95% CI: 1.01–1.89; p = 0.044) and increased maternal BMI (OR: 1.06, 95% CI: 1.01–1.10; p = 0.007) significantly raised the chance of giving birth to a girl. Conversely, PRG levels less than 20 ng/ml are associated with lower odds of male birth (OR: 0.72, 95% CI: 0.53–0.99; p = 0.044), and higher maternal BMI is associated with an almost statistically-significant lower chance of male birth (OR = 0.96, 95% CI: 0.92–1.00; p = 0.067). Conclusion: Higher BMI and PRG levels positively predicted female childbirth; conversely, elevated levels negatively predicted male delivery.

show abstract

Aneuploidy rates are not higher in women with obesity: Is it worth the “weight” to delay in vitro fertilization until body mass index decreases?

Cited by 2 publications

References 5 publications

Obesity and reproduction

Obesity and reproduction

A relationship between progesterone, maternal body weight, and offspring sex following the frozen/thawed single embryo transfer.

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