Anetoderma. Clinical findings, associations, and long-term follow-up evaluations

Venencie, Pierre Y.

doi:10.1001/archderm.120.8.1032

Cited by 90 publications

(94 citation statements)

References 24 publications

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“…Anetoderma can be either primary or secondary to an inflammatory dermatosis, such as syphilis, tuberculosis, lupus erythematosus, perifolliculitis, macular atrophy, lymphocytoma cutis, xanthoma, pilomatrixoma, nodular amyloid, systemic administration of penicillamine and mastocytosis [6]. Secondary anetoderma associated with mastocytosis has been sparsely reported in the medical literature [3,7,8,9]. Nevertheless, this presentation is not included in the comprehensive classification of mastocytosis [10].…”

Section: Discussionmentioning

confidence: 99%

“…The most common manifestation is urticaria pigmentosa (UP), which is characterized by small or larger brown-red maculopapules on the skin. Occasionally, elastic and collagen fibers in the lesions degenerate, resulting in a lax area of skin, termed anetoderma [3]. We report a patient with multiple cutaneous anetoderma lesions, presented since infancy.…”

Section: Introductionmentioning

confidence: 99%

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Secondary Anetoderma Associated with Mastocytosis

Kalogeromitros

Gregoriou

Makris

et al. 2006

Int Arch Allergy Immunol

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Background: Mastocytosis represents a wide spectrum of proliferative disorders of mast cells in the bone marrow, skin and/or internal organs. The most common manifestation is urticaria pigmentosa (UP), which is characterized by small or large brown-red maculopapules on the skin. Occasionally, elastic and collagen fibers in the lesions degenerate and result in a lax area of skin termed anetoderma. Methods: We report a 21-year-old male patient with multiple cutaneous anetodermic lesions, present since infancy, at UP sites confirmed with histochemistry. Results: Urinary N-methyl 24-hour histamine levels were elevated, but serum tryptase levels were within normal limits. Radiologic examination of long bones was unremarkable, as well as all other blood results. UP biopsy showed absence of epidermal involvement and increased number of mast cells located perivascularly. There was fragmentation of elastic fibers in the papillary dermis. Conclusions: A patient with multiple cutaneous anetodermic lesions, presented since infancy, led to the diagnosis of UP. Such an association is rare and raises intriguing questions concerning the pathogenesis of anetoderma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Secondary Anetoderma Associated with Mastocytosis

Kalogeromitros

Gregoriou

Makris

et al. 2006

Int Arch Allergy Immunol

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“…In the most usual form, crops of round or oval, pink macules 0.5-1 centimeter in diameter develop on trunk, thighs and upper arms, less commonly on the neck and face and rarely elsewhere. The lesions remain unchanged throughout life, and new lesions often continue to develop for many years [6]. Anetoderma has been classified as primary and secondary.…”

Section: Discussionmentioning

confidence: 99%

Anetoderma with positive Darier’s sign

Rafiei¹,

Eftekhari²,

Daryakar³

et al. 2017

Our Dermatol Online

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“…syphilis, especially in secondary syphilis but also in latent, congenital or tertiary syphilis, as well as lepra [1,2,5],…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies and Anetoderma: Are They Associated?

Stephansson

Niemi

1995

Dermatology

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Background: Macular atrophy or anetoderma is a rare skin disease of unknown pathogenesis, characterised by wrinkled or flaccid skin. Objective: The finding of anetoderma in 5 patients followed up because of false-positive seroreactions of syphilis prompted us to study the occurrence of antiphospholipid (aPL) antibodies in anetoderma. Methods: 14 unselected patients with primary anetoderma (PA) were collected from hospital records and clinical, immunological and histological findings were compared in the two patient groups. Results: Of the 5 patients, 3 fulfilled the criteria for antiphospholipid syndrome. In two cases, it was secondary to systemic lupus erythematosus (SLE). Of the 14 PA patients 1 had aPL antibodies and 4 had borrelia antibodies. Two patients had thyroid antibodies; 1 of them developed SLE. In several biopsy specimens, microthromboses were seen in both patient groups. Conclusion: On the basis of this study and our previous findings, it seems that anetoderma is more often associated with aPL-positive SLE or lupus-like disease than with aPL-negative disease. Immunological mechanisms play an important role in both primary and secondary anetoderma. The meaning of false-positive serological tests for syphilis or borrelia and aPL antibodies is not clear, but they may be reacting to some still unidentified antigen. Probably, various systemic as well as local inflammatory and non-inflammatory processes, e.g. microthromboses, can trigger anetoderma via still unknown pathomechanisms.

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Anetoderma. Clinical findings, associations, and long-term follow-up evaluations

Cited by 90 publications

References 24 publications

Secondary Anetoderma Associated with Mastocytosis

Secondary Anetoderma Associated with Mastocytosis

Anetoderma with positive Darier’s sign

Antiphospholipid Antibodies and Anetoderma: Are They Associated?

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