Anesthetic Profile of a Non-lipid Propofol Nanoemulsion

Sudo, Roberto T.; Bonfá, Laura; Trachez, Margarete M.; Debom, Roberto; Rizzi, Marisa D. R; Zapata‐Sudo, Gisele

doi:10.1016/s0034-7094(10)70059-3

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…It is worth mentioning that there are not many studies about clinical use of propofol Nanoemulsion. 9,11,14 The comparative study related to Propofol MCT-LCT and Propofol Nanoemulsion isn't readily available in our setting till date. Hence, Propofol Nanoemulsion and MCT-LCT Propofol formulations were compared in 100 patients undergoing elective surgery under general anaesthesia to see the incidence and severity of pain on injection.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Pain on Injection of Propofol MCT-LCT with Propofol Nanoemulsion for General Anaesthesia

Shakya

Vaidya

Paudel

2022

J. Nepalgunj Med. College

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Introduction: Pain during injection of propofol continues to be a major discomfort for patients. Different propofol formulations have been introduced to reduce the incidence of pain. Aims: To know the incidence, severity of pain at induction and post operative amnesic effect of two different formulations of propofol. Methods: This double-blinded comparative study involved randomly selected 100 patients undergoing elective surgery under general anesthesia with physical status score I or II (American Society of Anesthesiologists). Out of 100 patients, 50 received medium and long chain triglyceride Propofol (Group A) while another 50 received nanoemulsion Propofol (Group B) intravenously. Parameters measured and compared were the gender, age, weight, physical status score, pain on injection and postoperative recall of pain during injection of propofol. Results: Both groups were comparable with regards to age, gender, physical status score, mean duration of surgery. The presence of pain during injection with propofol in group A was 76% (38 patients) while 36% (18 patients) in group B which was statistically significant (p =0.0001). Severity of pain was more in group A which was statistically significant in comparison to group B (p=0.0001). The arm withdrawal during the injection of propofol was found more in Group A than Group B, 24% vs 0% (p=0.0002). Recall of pain after 4 hours postoperatively was found in 5 patients of Group A (10%) and 3 patients of Group B (6%) which came out to be statistically insignificant (p=0.715). There was no significant difference between groups regarding heart rate, mean arterial pressure, respiratory rate and arterial hemoglobin oxygenation at all assessed times (p > 0.05) intraoperatively. Conclusion: This study clearly shows the incidence and severity of pain on intravenous administration in nanoemulsion Propofol is significantly less. However, amnestic effect was equally present in both the groups.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Pain on Injection of Propofol MCT-LCT with Propofol Nanoemulsion for General Anaesthesia

Shakya

Vaidya

Paudel

2022

J. Nepalgunj Med. College

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“…Twenty male BALB/c mice (20-25 g) were randomized into four groups, and each group was intravenously injected with a saline, 0.6% acetic acid solution, Diprivan or propofol-mixed micelles at a dose of 5 mg/kg. The presence of local inflammation or tissue damage caused by the propofol preparation was evaluated after intraperitoneal administration [27]. The hematoxylin and eosin staining was performed on the peritoneal membranes sections and visualized under a light microscope.…”

Section: Histological Evaluationmentioning

confidence: 99%

Physicochemical Characterization and Pharmacological Evaluation of Novel Propofol Micelles with Low-Lipid and Low-Free Propofol

et al. 2022

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We developed safe and stable mixed polymeric micelles with low lipids and free propofol for intravenous administration, to overcome the biological barrier of the reticuloendothelial system (RES), reduce pain upon injection, and complications of marketed propofol formulation. The propofol-mixed micelles were composed of distearoyl-phosphatidylethanolamine-methoxy-poly (ethylene glycol 2000) (DSPE mPEG2k) and Solutol HS 15 and were optimized using Box Behnken design (BBD). The optimized formulation was evaluated for globule size, zeta potential, loading content, encapsulation efficiency, pain on injection, histological evaluation, hemolysis test, in vivo anesthetic action, and pharmacokinetics, in comparison to the commercialized emulsion Diprivan. The optimized micelle formulation displayed homogenous particle sizes, and the free drug concentration in the micelles was 60.9% lower than that of Diprivan. The paw-lick study demonstrated that propofol-mixed micelles significantly reduced pain symptoms. The anesthetic action of the mixed micelles were similar with the Diprivan. Therefore, we conclude that the novel propofol-mixed micelle reduces injection-site pain and the risk of hyperlipidemia due to the low content of free propofol and low-lipid constituent. It may be a more promising clinical alternative for anesthetic.

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“…The capacity of nanoemulsions to dissolve large amounts of hydrophobic molecules and the ability to protect medications from hydrolysis makes nanoemulsions ideal to deliver parenteral medications. Based on these principles, propofol has been reformulated as a nanoemulsion to reduce side effects, albeit with changes in pharmacokinetic and pharmacodynamic profiles [ 37 ]. Pain on injection is reduced with nanoemulsion preparations of propofol without clinically relevant side effects compared to soy lecithin formulations [ 38 ].…”

Section: Surface Tension Of Water and Clinical Implicationsmentioning

confidence: 99%

Water in the human body: An anesthesiologist's perspective on the connection between physicochemical properties of water and physiologic relevance

Riveros-Pérez

Riveros

2018

Annals of Medicine and Surgery

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The unique structure and multifaceted physicochemical properties of the water molecule, in addition to its universal presence in body compartments, make water a key player in multiple biological processes in human physiology. Since anesthesiologists deal with physiologic processes where water molecules are critical at different levels, and administer medications whose pharmacokinetics and pharmacodynamics depend on interaction with water molecules, we consider that exploration of basic science aspects related to water and its role in physiology and pharmacology is relevant to the practice of anesthesiology. The purpose of this paper is to delineate the physicochemical basis of water that are critical in enabling it to support various homeostatic processes. The role of water in the formation of solutions, modulation of surface tension and in homeostasis of body temperature, acid-base status and osmolarity, is analyzed. Relevance of molecular water interactions to the anesthesiologist is not limited to the realm of physiology and pathophysiology. Deep knowledge of the importance of water in volatile anesthetic effects on neurons opens a window to a new comprehensive understanding of complex cellular mechanisms underlying the practice of anesthesiology.

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Anesthetic Profile of a Non-lipid Propofol Nanoemulsion

Abstract: Non-lipid formulation of propofol can be a better alternative to CPL for intravenous anesthesia with fewer adverse effects.

Cited by 4 publications

References 20 publications

Comparative Study of Pain on Injection of Propofol MCT-LCT with Propofol Nanoemulsion for General Anaesthesia

Comparative Study of Pain on Injection of Propofol MCT-LCT with Propofol Nanoemulsion for General Anaesthesia

Physicochemical Characterization and Pharmacological Evaluation of Novel Propofol Micelles with Low-Lipid and Low-Free Propofol

Water in the human body: An anesthesiologist's perspective on the connection between physicochemical properties of water and physiologic relevance

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