Anesthetic preconditioning with sevoflurane in diabetic patients with increased cardiac risk, undergoing elective abdominal surgery

Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK

“…Volatile anesthetics (such as sevoflurane) are myocardial protective [3][4][5] , and are widely used in the induction of patients experiencing coronary artery bypass grafting (CABG) surgery in the operative and perioperative period. However, clinical trials have noted conflicting results in patients with obesity and diabetes 6 . Determining the etiology of the discrepancy between clinical and experimental data may reveal an important mechanistic understanding of the value of preconditioning by volatile anesthetics, and may yet yield their clinical applicability in diabetic patient cardioprotection.…”