Anesthetic Management of an Infant with Nesidioblastosis: A case report

Kim, Duck Kyoung; Bahk, Jae Hyon; Kim, Jong Sung; Min, Sang Il

doi:10.4097/kjae.1997.32.6.1031

Cited by 3 publications

(3 citation statements)

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“…A variety of dendrimers exists, and each has biological properties such as self-assembling, electrostatic interactions, chemical stability, low cytotoxicity. These varied characteristics make dendrimers "nonpareil" materials and to date, they represent a good choice in the medical field and for biomedical applications such as drug delivery nanocarriers, 3 biosensors, 4,5 bio imaging agents 6 and theranostics. 7 Dendrimers containing nitrogen atoms, which can be protonated at physiological pH, are deeply investigated as non-viral polymeric vectors [8][9][10][11][12][13][14][15][16][17] for delivering nucleic acids into specific cell of patients to replace defective genes (gene therapy).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Alfei¹,

Castellaro²,

Taptue³

2017

Org. Commun.

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Dendrimers, the emerging man made, highly branched, star-shaped macromolecules with nanometerscale dimensions are well known for their well defined and high controlled architecture, their versatility and high functionality and are of eminent interest in nanomedical applications such as drug delivery, gene transfection, and imaging. In this paper, versatile protocols for the synthesis of polyester-based, hydrolysable, polycationic dendrimers have been setup. A fourth generation dendrimer equipped with 48 peripheral hydroxyl groups was prepared from 2,2-bis(hydroxymethyl)propanoic acid and was used for grafting BOC-amino acids or as "hypercores" on which dendrons functionalized with BOC-amino acids were attached. A library of 15 polycationic homo-and hetero-dendrimers in the form of hydrochloride was obtained. Their structures and composition were confirmed by NMR analysis and by experimental molecular weight computed by volumetric titration. Their buffer capacity and results obtained from cytotoxicity assays and tests of binding with both pDNA and siRNA were very satisfactory. Keywords:Polyester-based polycationic dendrimers; 2, 2-bis(hydroxymethyl)propanoic acid; amino acids; pDNA and siRNA binding; buffer capacity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Alfei¹,

Castellaro²,

Taptue³

2017

Org. Commun.

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“…In terms of its novel characteristics, chitosan has already been widely applied in many fields. [5][6][7][8] Chitosan contains abundant free amino groups along the chain backbone that are cationically charged in acidic media. It has a prominent flocculating effect in water purification.…”

Section: Introductionmentioning

confidence: 99%

The flocculating properties of chitosan‐graft‐polyacrylamide flocculants (I)—effect of the grafting ratio

Yuan

Shang²,

et al. 2010

J of Applied Polymer Sci

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A series of chitosan-graft-polyacrylamide copolymers have been prepared as flocculants for waste water treatment. The results indicated that the grafting ratio was one of the key factors for the flocculating effects. The copolymers with various grafting ratios showed different flocculating properties. To observe every detail of this effect, the specific refractive index increment measurement (SRIIM) method was used to determine the grafting ratio at the beginning of this study. Interestingly, it was found that as the grafting ratio increased, the flocculating effect increased until it reached its maximum point. At that point, it decreased. This result was discussed in terms of the cooperative effects of the charge neutralization and bridging flocculating mechanisms. A structure model of chitosan-g-polyacrylamide copolymer flocculants has been proposed.

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“…For those novel characteristics, chitosan has been already applied widely in many fields, such as biotechnology, biomedicine, food, and cosmetics. [3][4][5][6][7] Furthermore, chitosan presents abundant free amino groups along the chain backbone that is cationically charged in a wide range of physiological pHs, and shows prominent flocculating effects in water purification. 1,2,8 However, chemical modified chitosan-based flocculants, such as polyacrylamide (PAM) grafted chitosan, [9][10][11] would bear more effective flocculating properties, which could overcome many disadvantages of chitosan itself, such as the low molecular weight and bad solubility, in practical application.…”

Section: Introductionmentioning

confidence: 99%

The flocculating properties of chitosan‐graft‐polyacrylamide flocculants (II)—Test in pilot scale

Zhang

Shang²,

Yuan

et al. 2010

J of Applied Polymer Sci

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In this study, the flocculating properties of chitosan-graft-polyacrylamide (PAM) copolymer flocculants have been investigated in pilot scale, and the raw water from Zhenjiang part of Yangtse river in China was used as simulated waste water. The influences of dose, mechanical mixing rate, and sedimentation time to the flocculating effects have been investigated in different seasons: summer and winter, respectively. The optimal experimental conditions have been studied by orthogonal test. In addition, the structure effects of the flocculants: the grafting ratio, on the flocculating properties have been also investigated in pilot scale, which results were fully consistent to those from the beaker experiment in laboratory scale using kaolin suspension as simulated waste water. Compared to poly ferric sulfate, current used flocculants in Jinxi Water Factory, chitosan-g-PAM copolymer flocculants showed better flocculating properties, which was ascribed to the cooperative effects of the charge neutralization and bridging flocculating mechanisms of polymer flocculants. V C 2010 Wiley Periodicals, Inc. J Appl Polym Sci

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Anesthetic Management of an Infant with Nesidioblastosis: A case report

Cited by 3 publications

References 0 publications

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

The flocculating properties of chitosan‐graft‐polyacrylamide flocculants (I)—effect of the grafting ratio

The flocculating properties of chitosan‐graft‐polyacrylamide flocculants (II)—Test in pilot scale

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