Anesthetic Management of a Patient With Restless Legs Syndrome: A Case Report

Abstract

Restless legs syndrome (RLS) is a neurological sensory disorder associated with sensory and motor symptoms that most commonly occur at night and during periods of rest. It is characterized by altered or abnormal sensations primarily in the legs and the urge to move the associated limbs. Perioperative procedures, including general anesthesia, can cause exacerbations of RLS. This is a case report of a suspected RLS exacerbation in a 22-year-old woman who had no formal diagnosis of RLS despite reporting symptoms that met all essential diagnostic criteria by the International RLS Study Group. Despite her previous diagnoses of dehydration induced-muscle pain or nocturnal cramps, we suspected her to have RLS. The patient underwent general anesthesia for a bilateral sagittal split ramus osteotomy using a combined inhalational and intravenous anesthetic technique with sevoflurane, propofol, remifentanil, and dexmedetomidine. After successful completion of the surgery and returning to the ward, she began moving her lower extremities and complaining of unpleasant sensations in both ankles. Bed rest exacerbated the suspected RLS symptoms despite a continuous infusion of dexmedetomidine. The RLS symptoms continued to worsen and spread to her upper extremities. After increasing the dexmedetomidine infusion from 0.2 to 0.4 μg/kg/h, almost all symptoms improved, and she slept for 3 hours. Upon awakening, the unpleasant sensations were completely relieved by walking and stretching. The patient was formally diagnosed with RLS by a neurologist after discharge. In this case, an infusion of dexmedetomidine was helpful in successfully managing a suspected exacerbation of RLS.

Does Dexmedetomidine Improve or Worsen Restless Leg Syndrome under Sedation: A Case Report and Extensive Review

“…Restless leg syndrome (RLS) [ 1 ] is a relatively common condition affecting from 1% to 15% of the general population [ 2 ] and may be challenging to treat if present during moderate to deep sedation [ 3 ]. Dexmedetomidine has been reported to improve RLS during sedation [ 3 ].…”

“…Restless leg syndrome (RLS) [ 1 ] is a relatively common condition affecting from 1% to 15% of the general population [ 2 ] and may be challenging to treat if present during moderate to deep sedation [ 3 ]. Dexmedetomidine has been reported to improve RLS during sedation [ 3 ]. We report a case where dexmedetomidine may have worsened RLS associated lower extremity movement during sedation and then present the current literature on RLS, and the case report is describing dexmedetomidine actions improving RLS during sedation.…”