“…The difference in body fluid compartments size, the low muscle mass and the low fat deposits, in addition to higher blood flow per organ unit of weight, influence drugs spread to the active site and the secondary distribution Volume replacement and blood loss should be evaluated step by step. These are major concerns in this type of surgery, especially when there is involvement of single organs, such as heart and liver 2,7, [17][18][19][20] . In our case, although not having this problem, that is, heart and liver were double organs, we have evaluated replacement by observing children's vital signs separately.…”