“…Over one-half of children with mastocytosis are symptomatic, and the most common symptoms include flushing and pruritis, mostly related to mastocyte release of histamine, prostaglandin-D2 (PG-2), and leukotriene-C4 [1,4,[16][17][18][19]. Bronchospasm, a typical sequela of IgE-mediated reactions, it not a common mediator-related incident in mastocytosis [17,20,21]. Children often report gastrointestinal symptoms, for example abdominal pain and diarrhea, and neurologic manifestations including mental status changes, syncope, and seizures under stress conditions [5,22,23].…”