Anesthésie caudale en chirurgie pédiatrique

Giaufre, E.; Morisson-Lacombe, G.

doi:10.1016/s0750-7658(83)80070-7

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Cited by 4 publications

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“…diazepam (Bruguerolle, 1986). The use of a mixture of local anaesthetics did not appear to influence the plasma concentrations of the component drugs since our data are comparable with those observed using separate injections (Camboulives et al, 1986;Ecoffey et al, 1985;Eyres et al, 1985;Giaufre et al, 1983). Furthermore, there is no analytical interference between the two drugs (Prat & Bruguerolle, 1987).…”

Section: Discussionsupporting

confidence: 82%

The influence of diazepam on the plasma concentrations of bupivacaine and lignocaine after caudal injection of a mixture of the local anaesthetics in children.

Giaufre

Bruguerolle

Morisson-Lacombe

et al. 1988

Brit J Clinical Pharma

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Twenty‐one children undergoing surgery received a caudal block using 1 ml kg‐1 of a mixture of 50% lignocaine (1%) and 50% bupivacaine (0.25%). They were randomized into two groups, one of which received diazepam 10 mg rectally as premedication. Diazepam administration resulted in significantly higher Cmax and AUC values for bupivacaine but did not influence the plasma concentrations of lignocaine.

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Section: Discussionsupporting

confidence: 82%