Anesthesia in Ophthalmic Surgery

Brunson, David B.

doi:10.1016/s0195-5616(80)50042-2

Cited by 29 publications

(23 citation statements)

References 5 publications

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“…All of the patients in the current study were positioned in lateral recumbency. There is no information relating specifically to the effects of a lateral recumbent position on intraocular pressure, but it is known that intraocular pressure is affected by extraocular muscle tone, scleral rigidity, and aqueous humour production and drainage (Brunson 1980). Aqueous humour production and drainage, in turn, can be influenced by changes in central nervous system output, blood pressure and venous drainage (Cunningham and Barry 1986).…”

Section: Discussionmentioning

confidence: 99%

Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs

Raušer¹,

Mrázová²,

Zapletalová³

2016

Vet. Med. - Czech

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ABSTRACT:The present prospective, randomised, double-blinded clinical study was designed to investigate the commonly used anaesthetic combinations of dexmedetomidine-propofol-isoflurane and medetomidine-propofolisoflurane on intraocular pressure and pupil size in dogs. Forty client-owned healthy dogs with no ocular abnormalities, average body weight of 25.7 ± 13.1 kg (mean ± SD) and aged 3.7 ± 2.7 years, were enrolled. Twenty four males and 16 females were included. Dogs were allocated randomly to receive dexmedetomidine i.v. at 0.005 mg/ kg, dexmedetomidine at 0.01 mg/kg, medetomidine at 0.01 mg/kg or medetomidine at 0.02 mg/kg. Ten minutes later anaesthesia was induced in all dogs with propofol and maintained with isoflurane in oxygen-air. Intraocular pressure, pupil size, heart rate, respiratory frequency and arterial blood pressures (SAP, DAP) were measured prior to (baseline) and at 10 (before propofol), 20, 30, 40, 50 and 60 min after dexmedetomidine or medetomidine administration. Oxygen saturation of haemoglobin (SpO 2 ) and end-tidal CO 2 concentration (EtCO 2 ) was monitored following anaesthesia induction. Data were analysed using Anderson-Darling and Bartlett's tests for data distribution and homogeneity of variance confirmation and ANOVA followed by Dunnett's tests for multiple comparisons. Changes were considered significant when P < 0.05. Following drug administration, pupil size, heart rate and respiratory frequency decreased significantly within groups, but did not differ between groups. No significant changes in intraocular pressure, SAP and DAP within and between groups, and SpO 2 or EtCO 2 between groups, were observed. Comparable doses of dexmedetomidine or medetomidine combined with propofol and isoflurane induced reductions in pupil size, respiratory frequency and heart rate, however, without a significant influence on intraocular pressure or arterial blood pressure.

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Section: Discussionmentioning

confidence: 99%

Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs

Raušer¹,

Mrázová²,

Zapletalová³

2016

Vet. Med. - Czech

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“…Outros autores já haviam relatado que o aumento da pressão arterial de CO 2 (PaCO 2 ) elevava a Po (3)(4) . A PaCO 2 pode ser mensurada através da pressão alveolar de CO 2 expirado (ETCO 2 ) (21) .…”

Section: Discussionunclassified

“…A pressão intra-ocular (Po) é a pressão exercida pelo conteúdo do olho contra a parede que o contém (1)(2) , sendo determinada pela taxa de produção e drenagem de humor aquoso, pelo volume do vítreo, volume sangüíneo da coróide, rigidez da esclera, tensão do músculo orbicularis oculi e pela pressão externa (1)(2)(3)(4)(5)(6) . A compressão externa do globo, por meio da contração dos múscu-los extra-oculares, pode aumentar diretamente a Po ou pode ter efeitos indiretos, induzindo a alterações nos volumes dos componentes intra-oculares (1,4) .…”

Section: Introductionunclassified

“…A compressão externa do globo, por meio da contração dos múscu-los extra-oculares, pode aumentar diretamente a Po ou pode ter efeitos indiretos, induzindo a alterações nos volumes dos componentes intra-oculares (1,4) .…”

Section: Introductionunclassified

“…Fármacos utilizados na anestesia podem afetar a Po agindo diretamente sobre o diencéfalo, facilitando ou inibindo a produção do humor aquoso, relaxando ou contraindo o músculo orbicularis e os músculos extra-oculares ou, ainda, indiretamente, por meio dos efeitos sobre os sistemas cardiovascular e respiratório (1,4,9) . Muitos autores enfatizam a importância dos anestésicos na cirurgia oftálmica e relatam a redução da Po com os agentes intravenosos e inalatórios (2,6) .…”

Section: Introductionunclassified

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