Aim: Renal transplantation (RT) is the most effective treatment modality for end-stage renal disease (ESRD). Transplantation process requires a multidisciplinary (nephrologist, surgeon, anesthetist, pathologist, immunologist, and experienced nurse) approach. This study presents the first-year experience of the anesthesiology department of a university hospital where renal transplantation program just started. Material and Method: The digital medical files of 14 patients who underwent renal transplantation due to ESRD between 2017 and 2018 were evaluated retrospectively. The hemodynamic and demographic parameters of all the patients were examined and analyzed. Results: Eleven (78.6%) of the donors were provided from deceased and 3 (21.4%) from living individuals. The mean age of all transplantation patients were 39.9±13.3 years (range 21-61). Concerning cause, "unknown etiology" was detected in 8 (57.1%) of the patients. None of the patients experienced difficult intubation. The mean duration of anesthesia was 242.8 ± 85.2 min. Intraoperative hypotension was detected in 6 (42.8%) patients. During the intraoperative period, 1535 ± 771 ml of 0.9% NaCl was administered as the fluid maintenance. Only 2 patients had intraoperative complications. No mortality was observed during the perioperative period. Two of the 14 patients experienced loss of the transplanted kidney. The survival rate of the grafts was 85.8%. Discussion: Management of renal transplantation is a serious task which requires teamwork and cooperation as it can favorably change the patient's life quality when implemented successfully. In renal transplantation, achieving the post-transplantation survival rate (90-96%) reported in the literature requires detailed preoperative evaluation of patient along with appropriate intraoperative fluid administration and hemodynamic control.