Anesthesia for Epilepsy Surgery

Banik, Sujoy; Venkatraghavan, Lashmi

doi:10.1007/978-981-13-3387-3_11

Cited by 1 publication

(2 citation statements)

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“…In a previously unpublished conference abstract, the authors found that the reduced hippocampal volume was associated with agitated emergence from anesthesia after epilepsy surgery. [ 5 ] They did not find the correlation coefficient in their study. The difference in this study is that we have tried to correlate hippocampal volume after a short duration of sedation unlike after a complete duration of surgery.…”

Section: Discussionmentioning

confidence: 82%

“…[ 3 ] Previously, an unpublished study showed that the reduced hippocampal volume may contribute to agitated emergence after anesthesia following epilepsy surgery. [ 5 ] The hippocampal electrical activity is shown to have a direct correlation with sleep, wakefulness, and arousal after anesthesia. [ 6 ] Several molecular and electrophysiological studies have shown that various factors (sevoflurane/etomidate anesthesia and temporal lobe resection leading to hippocampal atrophy in epilepsy patients) affect hippocampal cells or electrical activity and may cause a delay in recovery from general anesthesia.…”

Section: Introductionmentioning

confidence: 99%

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Hippocampal volume and recovery profile following propofol sedation in children undergoing magnetic resonance imaging: An exploratory study

Srinivasa,

Mishra,

Bhadrinarayan

et al. 2024

Saudi Journal of Anaesthesia

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Background: Reduction in the hippocampal volume may contribute to agitated and delayed emergence after anesthesia in epilepsy surgery. We hypothesized that hippocampal volume and the duration of various recovery parameters after a short duration of sedation may be correlated. The primary objective was to evaluate the correlation between hippocampal volumes with time to recovery after the stoppage of propofol infusion. Methods: After obtaining Institute Ethical Clearance, we included all children of the age group 5–17 years, who needed sedation for brain magnetic resonance imaging (MRI) for at least 20–60 minutes for the evaluation of epilepsy. The hippocampal volume was estimated bilaterally in the pre-contrast volumetric magnetization-prepared rapid gradient-echo (MPRAGE) brain imaging by the radiologist using statistical parametric mapping. The correlation of hippocampal volume with recovery and time to discharge (assessed by the modified Aldrete score (MAS)) was obtained using Spearman's correlation coefficient (rho). A rho > ± 0.5 was considered a good correlation between the variables. Results: Data on a total of 18 children (10 males and 8 females) who required sedation for an MRI were studied over a period of six months. The correlation coefficients of right and left corrected hippocampal volumes with time to spontaneous eye opening were -0.052 and -0.195, respectively. The correlation coefficients of right and left corrected hippocampal volumes with time to respond to oral commands were -0.017 and -0.219, respectively. Conclusion: There was a weak negative correlation between hippocampal volumes and recovery parameters after a short duration of sedation with propofol in children.

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Section: Discussionmentioning

confidence: 82%