Anesthesia Case of the Month

Mathews, Lindsey; Killos, Maria; Graham, Lori

doi:10.2460/javma.239.3.307

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…In the veterinary literature, Mathews and others (2011) reported a case of cardiopulmonary arrest in a French bulldog after extubation and administration of hydromorphone: the author concluded that extubation was the more likely responsible for the cardiac arrest. The typical high vagal tone of brachycephalic dogs was considered by the author to be a possible predisposing factor.…”

Section: Discussionmentioning

confidence: 99%

Severe bradycardia after hypoxaemia and endotracheal intubation and cardiac arrest following glycopyrrolate in a dog

Scarabelli

Rigotti

Alderson

2017

Vet Record Case Reports

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A nine-year-old neutered male Yorkshire terrier with history of chronic cough underwent bronchoscopy and bronchoalveolar lavage; general anaesthesia was maintained with a variable rate infusion of propofol, and oxygen was insufflated via a urinary catheter in the trachea. At the end of the procedure, desaturation occurred; endotracheal intubation was performed and was immediately followed by severe bradycardia and respiratory arrest. Glycopyrrolate (5 µg/kg) was administered leading to cardiac arrest. Apnoea and asystole were quickly treated with manual positive pressure ventilation, external chest compressions and intravenous administration of 0.04 mg/kg of atropine. This case describes vagally induced bradycardia after intubation, possible predisposing factors and its treatment/prevention with antimuscarinic drugs.

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Section: Discussionmentioning

confidence: 99%

Severe bradycardia after hypoxaemia and endotracheal intubation and cardiac arrest following glycopyrrolate in a dog

Scarabelli

Rigotti

Alderson

2017

Vet Record Case Reports

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“…Brachycephalic dogs have a higher vasovagal tonus index than other breeds (Doxey & Boswood ). A previous report showed that concurrent hydromorphone administration and tracheal extubation increased vagal tone, which led to bradycardia, asystole and sudden cardiopulmonary arrest (Mathews et al ). The high vagal tone in the first case of this report may have made the dog more susceptible to vagally mediated responses following fentanyl administration, that lead to asystole (Mathews et al ).…”

Section: Discussionmentioning

confidence: 99%

Fentanyl‐induced asystole in two dogs

Jang

Son

Lee

2015

J of Small Animal Practice

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Fentanyl is used in small animals for perioperative analgesia during anaesthesia. Severe bradycardia and asystole were observed on bolus administration of a 3 µg/kg loading dose of fentanyl in two dogs under isoflurane anaesthesia. Premedication with 10 µg/kg glycopyrrolate did not prevent asystole in the first case; and although bradycardia was treated with 5 µg/kg glycopyrrolate administered intravenously in the second case, the heart rate continuously decreased and asystole subsequently developed. Asystole in both cases was quickly corrected by intravenous administration of 0 · 04 mg/kg atropine and closed chest compressions. This case report describes asystole induced by fentanyl administration in isoflurane anaesthetised dogs. Atropine was more effective than glycopyrrolate in the treatment of fentanyl-induced asystole.

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