Anesthesia and dementia: An up-to-date review of the existing literature

Tsolaki, Magda; Sia, Eleni; Giannouli, Vaitsa

doi:10.1080/23279095.2022.2110871

Cited by 6 publications

(2 citation statements)

References 92 publications

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“… 4 But research also discusses other potential risk factors for dementia, such as previous anesthesia in youth or stressful life events. 6 , 7 If the three risk factors social isolation, physical inactivity, and depression are reduced in later life, the prevalence of dementia is expected to decrease by 13%. 4 Volunteering is a promising approach to reducing these three important risk factors.…”

Section: Introductionmentioning

confidence: 99%

Does Voluntary Work Contribute to Cognitive Performance? – An International Systematic Review

Keefer¹,

Steichele²,

Graessel³

et al. 2023

JMDH

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Introduction There is a need for knowledge on activities that can reduce cognitive decline and dementia risk. Volunteering is a productive activity that entails social, physical, and cognitive functions. Therefore, volunteering could be a protective factor for cognitive loss. Thus, this review aims to examine the associations between volunteering and volunteers’ cognition and to identify influencing variables. Methods Six international literature databases were searched for relevant articles published between 2017 and 2021 (ALOIS, CENTRAL, CINAL, Embase, PsycINFO, PubMed). Quantitative studies of all study designs were included. The primary outcome was the volunteers’ cognition measured by objective, internationally established psychometric function tests. Two authors independently assessed the eligibility and quality of the studies. A narrative synthesis was performed using all studies included in this review. The methodology was in line with the PRISMA guidelines. Results Fourteen studies met the inclusion criteria and were included. Seven of the included studies confirmed that volunteering positively affects the volunteers’ cognitive function. Two other studies identified an association between volunteer activity and volunteers’ cognition using cross-sectional measurements. In particular, women and people with a low level of education benefit from the positive effects and associations. The study quality of the included articles was moderate to weak. Discussion Our review suggests that volunteering can improve volunteers’ cognition. Unfortunately, little attention is given to specific volunteer activities and the frequency of engagement. Additionally, more attention is needed on various risk factors of cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Does Voluntary Work Contribute to Cognitive Performance? – An International Systematic Review

Keefer¹,

Steichele²,

Graessel³

et al. 2023

JMDH

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show abstract

“…Halogenated anesthesia is widely used in clinical practice to provide the necessary sedation for lifesaving surgical procedures. Multiple studies conducted over the last two decades have shown that inhalational anesthetics are inherently neurotoxic, causing biochemical and morphological changes that result in neuronal loss, cognitive de cits [1][2][3], and even neurodegenerative disease [4,5].…”

Section: Introductionmentioning

confidence: 99%

HSP90 inhibition attenuated isoflurane-induced neurotoxicity in mouse and human neuroglioma cells

Zhang

Chen

Liu

et al. 2023

Preprint

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Isoflurane is one of the most popular inhalation anesthetics in the clinical practice but presenting an increased risk of neuronal injury. Hsp90 has been indicated to present an important role for maintaining neuronal homeostasis under the stress. However, the effect of hsp90 during isoflurane exposure is poorly understood. Here in this study, we aimed to observe the protect effect of hsp90 inhibition, and investigate the potential regulatory mechanism after isoflurane exposure. We found that hsp90 inhibitor, 17AAG, showed a great protective effect in maintaining isoflurane-induced ferroptosis of mice hippocampus and cultured neuronal cells. We focus on the crucial protein GPX4 activity in ferroptosis, and found that the 17 AAG contributed its protect effect to preserve physiological level of GPX4 activity under isoflurane exposure, although 17AAG could restored the protein level of GPX4. Further, we observed CMA pathway was activated and then mediated GPX4 degradation under isoflurane exposure. And 17AAG could interfere the complex between hsp90 and lamp2a to inhibit CMA activity, followed by blocking GPX4 degradation, which further affected the isoflurane-induced ferroptosis. Based on these findings, we proposed that hsp90 inhibition as a protective mechanism against isoflurane-induced ferroptosis in neurons.

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HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells

Zhang,

Chen,

Liu

et al. 2023

Neurochem Res

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Anesthesia and dementia: An up-to-date review of the existing literature

Cited by 6 publications

References 92 publications

Does Voluntary Work Contribute to Cognitive Performance? – An International Systematic Review

Does Voluntary Work Contribute to Cognitive Performance? – An International Systematic Review

HSP90 inhibition attenuated isoflurane-induced neurotoxicity in mouse and human neuroglioma cells

HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in Mice and Human Neuroglioma Cells

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