Anesthesia and Analgesia for Laboratory Rodents

Gaertner, Diane J.

doi:10.1016/b978-012373898-1.00010-4

Cited by 44 publications

(106 citation statements)

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“…We did not find any specific references on this difference between genders, but Gaertner et al (2008), indicated a higher mortality for the diazepam/ketamine combination within 15 min of induction with a combination at 7.5-10 mg/kg diazepam/60-80 mg/kg ketamine, and commented that higher mortality was observed when compared with other multimodal anaesthesia methods. In spite of this, the diazepam/ketamine combination is frequent in the anaesthesia of different animal species (Flecknell 2009), although it has been reported that it can cause respiratory depression and death.…”

Section: Discussionmentioning

confidence: 94%

“…The combination of some depressors with the dissociative anaesthetic ketamine remains one of the first choices for injectable rodent anaesthesia (Murray et al 2000;Gaertner et al 2008), due to its easy i.p. administration, relative safety among injectable agents, and ability to produce CNS effects such as catalepsia, analgesia, dissociation from environment and amnesia (Murray et al 2000;Richardson and Flecknell 2005;Baker et al 2011;Kawai et al 2011).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of different central nervous system depressors combined with ketamine for anaesthesia in mice

Serrano-Caballero¹,

Molina²,

Lora³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to compare some depressors of the central nervous system combined with ketamine in order to find an adequate scombination for anaesthesia in mice, coupled with a simple, easy to use and reliable method. Forty Swiss OF-1 mice (Mus musculus), 20 females and 20 males with a body weight from 35 to 45 g aged from 12 to 16 weeks, were used to evaluate one of the following central nervous system depressors (CNSD): acepromazine (5 mg/kg), diazepam (5 mg/kg), medetomidine (1 mg/kg), midazolam (5 mg/kg) and xylazine (10 mg/kg) combined with the dissociative anaesthetic ketamine (100 mg/kg) by the intraperitoneal route. Different parameters were evaluated at regular intervals to assess the depth of anaesthesia (time of induction, time of loss and recovery of pedal withdrawal reflex, time of recovery from the anaesthesia), and respiratory and heart rate and oxygen saturation. Most of the assessment times and physiological parameters were exhibited earlier in females than in males but, in most cases, these differences were not significant. The diazepam combination resulted in death in half of the male group. Significant differences for the combination comparison were found for induction, pedal withdrawal reflex and recovery from anaesthesia, as well as for respiratory and heart rate and oxygen saturation. The best results for mice of both genders, i.e. induction, maintenance and recovery from anaesthesia were more stable with α 2 -agonists than with other combinations (benzodiazepines or acepromazine), which did not reach a good anaesthetic level, that is, an adequate anaesthetic plane with an absence of the pedal withdrawal reflex and the maintenance of stable vital constants.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Evaluation of different central nervous system depressors combined with ketamine for anaesthesia in mice

Serrano-Caballero¹,

Molina²,

Lora³

et al. 2013

Vet. Med. - Czech

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“…After being euthanised by isoflurane inhalation (Gaertner et al 2008), animals were dissected through the ventral surface, to expose the abdominal cavity and the gastrointestinal tract; the stomach, small intestine, large intestine and cecum were examined. Parasites were isolated, washed with water, fixed in 70% ethanol and then diagnosed.…”

Section: Methodsmentioning

confidence: 99%

A survey study on the helminth parasites of two wild jirds,Meriones shawiandM. libycus(Rodentia: Gerbillinae), in Tunisian desert areas

Khemiri

Jrijer²,

Neifar³

et al. 2017

The European Zoological Journal

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A parasitological survey of 107 jirds, belonging to two species, Meriones shawi and M. libycus, was carried out. Rodents were trapped in three separate desert regions of Tunisia: Bouhedma (in the centre), Dghoumes (in the southwest) and Sidi Toui (in the southeast). The survey revealed infection with nine helminth species -six cestodes: Raillietina sp., Meggittina numida, Meggittina gerbilli and Inermicapsifer madagascariensis, and two Taeniidae species: Taenia endothoracicus and Taenia sp.; and three nematodes: Gongylonema neoplasticum, Physaloptera sp. and Trichuris gerbilli. The overall prevalence of helminth infection was 68.22% (73/107); the highest rate was in M. shawi (80.82%, 59 cases), whereas it was 41.17% (14 cases) in M. libycus. The most frequent helminth was Raillietina sp. (53.27%) followed by Meggittina numida (21.5%). Meriones shawi showed the highest helminth diversity with eight parasite species, with synchronous infections of two, three and four species of helminths in one rodent, compared to M. libycus in which only two cestode species were found, without synchronous infection. Moreover, significant differences in the overall infection prevalence between sexes (60.27 and 39.73% for males and females, respectively) and age were detected; only one juvenile specimen of M. shawi was found infected. Prevalence depended also on habitat: the highest infection rate was in Bouhedma (80%), followed by Dghoumes (58.33%), and the lowest was in Sidi Toui (47.82%).

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“…Pain relief is essential in surgical procedures since it optimizes postoperative care and well-being of animals [1]. In this sense, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) includes anti-inflammatory, analgesic and antipyretic effects, via inhibition of cyclooxygenase (COX) enzyme, particularly COX-2, which plays a major role in prostaglandin (PG) synthesis [2,3].…”

Section: Introductionmentioning

confidence: 99%

Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice

Schlapp

Goyeneche

Fernandez

et al. 2015

J Assist Reprod Genet

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Purpose To evaluate the effect of the nonsteroidal antiinflammatory drugs tolfenamic acid and flunixin meglumine in pregnancy rate and embryo survival of recipient mice subjected to embryo transfer. Methods A total of 142 recipient females were transferred with 2,931 embryos and treated with a single injection of tolfenamic acid (1 mg/kg; n=54 females with 1,129 embryos), flunixin meglumine (2.5 mg/kg; n=46 females with 942 embryos), or bi-distilled water (10 mL/kg) as control group (n=42 females with 860 embryos). Pregnancy was checked 2 weeks after embryo transfer, delivery was registered on the due date, and litter size was recorded on Day 7 after birth. Results Pregnancy rate of tolfenamic acid treated females was significantly higher than flunixin group (P<0.05) and showed a tendency to be higher when compared to the control group (P=0.06). The number of pups born from transferred embryos in pregnant females was significantly higher for both treatment groups compared to controls (P<0.05). Number of pups from total transferred embryos was higher for both treatment groups (P<0.05) when compared to controls. Conclusion The use of tolfenamic acid at the time of embryo transfer improves both pregnancy rate and number of live pups in recipient mice, with optimal effects observed with flunixin meglumine. We suggest that the use of tolfenamic acid has beneficial effects on the maintenance of pregnancy and embryo survival in recipient mice, which should be taken into account for further studies in other mammalian females.

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Anesthesia and Analgesia for Laboratory Rodents

Cited by 44 publications

References 0 publications

Evaluation of different central nervous system depressors combined with ketamine for anaesthesia in mice

Evaluation of different central nervous system depressors combined with ketamine for anaesthesia in mice

A survey study on the helminth parasites of two wild jirds,Meriones shawiandM. libycus(Rodentia: Gerbillinae), in Tunisian desert areas

Administration of the nonsteroidal anti-inflammatory drug tolfenamic acid at embryo transfer improves maintenance of pregnancy and embryo survival in recipient mice

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