Anencephaly and spina bifida among Hispanics: Maternal, sociodemographic, and acculturation factors in the National Birth Defects Prevention Study

Canfield, Mark A.; Ramadhani, Tunu A.; Shaw, Gary M.; Carmichael, Suzan L.; Waller, D. Kim; Mosley, Bridget S.; Royle, Marjorie H.; Olney, Richard S.

doi:10.1002/bdra.20582

Cited by 72 publications

(73 citation statements)

References 34 publications

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“…For this reason, during the antenatal period, folic acid supplementation is important for the prevention of NTDs. For supplementation, folic acid has been added to grain products in developed countries for the last 20 years [16]. We found that none of the mothers had folic acid support before and during pregnancy, which may indicate the necessity of adding folic acid to grain products in our country.…”

Section: Discussionmentioning

confidence: 92%

Clinical Characteristics of Neonatal Meningomyelocele Cases and Effect of Operation Time on Mortality and Morbidity

Bülbül

Can²,

Bülbül³

et al. 2010

Pediatr Neurosurg

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Objective: We aimed to evaluate the clinical features, short-term prognosis, and effect of operation time on mortality and morbidity in neonates with meningomyelocele. Methods: This prospective study was conducted between January 2006 and December 2008. Clinical features, defective area, existence of additional anomalies, operation time, and morbidity and mortality data were recorded. The effectof operation time on mortality and morbidity was evaluated. Results: Patients (n = 28) were assessed during the study period. Mean birth weight, height, and head circumference were found to be 3,160 ± 582 g, 46.2 ± 3.3 cm, and 36.7 ± 4.1 cm, respectively. None of the mothers received folate supplementation. Hydrocephaly (n = 13), pes equinovarus (n = 4), pelvicalyceal ectasia (n = 4), acetabular dysplasia (n = 2), Chiari II malformation (n = 2), and hydronephrosis (n = 2) accounted for additional anomalies. The mean postnatal age for surgical operation was 3.2 ± 2.8 days; mean length of hospital stay was 10.2 ± 9.7 days. The cases operated after 72 h were hospitalized longer, received antibiotherapies for a longer duration and had higher total complication rates (p = 0.04, 0.02, and 0.01, respectively). Conclusion: Surgical operation of patients with meningomyelocele within 72 h after delivery significantly reduces not only the duration of hospitalization and antibiotic usage, but also complication rates.

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Section: Discussionmentioning

confidence: 92%

Clinical Characteristics of Neonatal Meningomyelocele Cases and Effect of Operation Time on Mortality and Morbidity

Bülbül

Can²,

Bülbül³

et al. 2010

Pediatr Neurosurg

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“…The protective effect associated with being foreign born is not consistent for all birth outcomes. For example, foreign-born women and less acculturated women tend to be at greater risk of gestational diabetes and of delivering infants with serious neural tube defects than U.S.-born women (McDonald et al, 2008;Canfield et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Maternal nativity as a risk factor for gastroschisis: A population‐based study

Salemi

Pierre

Tanner

et al. 2009

Birth Defects Research

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BACKGROUND:The prevalence of gastroschisis is increasing in many parts of the world, although the etiology is largely unexplained. Young maternal age has been the only consistently identified, strong risk factor. The objective of this study was to examine the role of maternal nativity in relation to other suspected risk factors for gastroschisis in Florida. METHODS: We conducted a retrospective cohort study of singleton infants born in Florida from 1998-2003. Gastroschisis cases were identified from the Florida Birth Defects Registry. Demographic and perinatal data were obtained from birth records. Multivariable Poisson regression was used to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) for each factor of interest. RESULTS: The 6-year birth prevalence of gastroschisis was 3.26 per 10,000 live births, and the annual rate increased 41% during the study period. In addition to maternal age and marital status, maternal race/ethnicity and nativity were significantly associated with the risk of delivering an infant with gastroschisis. Compared with non-Hispanic white women, non-Hispanic black women had the lowest risk of delivering an infant with gastroschisis (PR, 0.19; 95% CI, 0.13-0.26), followed by Hispanic women (PR, 0.60; 95% CI, 0.43-0.83). Women born outside the United States were significantly less likely than U.S.-born women to deliver an infant with gastroschisis (PR, 0.59; 95% CI, 0.41-0.86). CONCLUSIONS: Although young maternal age remains a strong significant risk factor for gastroschisis in Florida, other factors such as maternal race/ ethnicity and nativity could be important in explaining the increasing prevalence of gastroschisis. Birth

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“…Using data from twenty-five population-based surveillance systems from 2005-2007, Hispanic women were estimated to be 1?21 (95 % CI 1?11, 1?31) times more at risk for an NTDaffected pregnancy than non-Hispanic white women (6) . Other researchers have also suggested that acculturation could be a risk factor for NTD (13,24,25) . However, this relationship has not been reported consistently and has been shown to vary for other birth defects (24) .…”

Section: Discussionmentioning

confidence: 99%

Modelling fortification of corn masa flour with folic acid and the potential impact on Mexican-American women with lower acculturation

Hamner

Tinker

Flores

et al. 2012

Public Health Nutr.

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Objective: Hispanics with lower acculturation may be at higher risk for neural tube defects compared with those with higher acculturation due to lower total folic acid intake or other undetermined factors. Modelling has indicated that fortification of corn masa flour with folic acid could selectively target Mexican Americans more than other race/ethnicities. We assessed whether fortification of corn masa flour with folic acid could selectively increase folic acid intake among Mexican-American women with lower acculturation, as indicated by specific factors (language preference, country of origin, time living in the USA). Design: We used dietary intake and dietary supplement data from the National Health and Nutrition Examination Survey 2001-2008, to estimate the amount of additional total folic acid that could be consumed if products considered to contain corn masa flour were fortified at 140 mg of folic acid per 100 g of corn masa flour. Setting: USA. Subjects: Non-pregnant women aged 15-44 years (n 5369). Results: Mexican-American women who reported speaking Spanish had a relative percentage change in usual daily total folic acid intake of 30?5 (95 % CI 27?8, 33?4) %, compared with 8?3 (95 % CI 7?3, 9?4) % for Mexican-American women who reported speaking English. We observed similar results for other acculturation factors.

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Anencephaly and spina bifida among Hispanics: Maternal, sociodemographic, and acculturation factors in the National Birth Defects Prevention Study

Cited by 72 publications

References 34 publications

Clinical Characteristics of Neonatal Meningomyelocele Cases and Effect of Operation Time on Mortality and Morbidity

Clinical Characteristics of Neonatal Meningomyelocele Cases and Effect of Operation Time on Mortality and Morbidity

Maternal nativity as a risk factor for gastroschisis: A population‐based study

Modelling fortification of corn masa flour with folic acid and the potential impact on Mexican-American women with lower acculturation

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