Anemias

Broadway-Duren, Jacqueline B.; Klaassen, Hillary

doi:10.1016/j.ccell.2013.09.004

Cited by 36 publications

(19 citation statements)

References 30 publications

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“…The burden of anaemia was twofold more among non-SMC subjects than among SMC subjects, and the haematocrit levels of SMC subjects were significantly higher than those of non-SMC subjects. Several anaemia-inducing factors that affect haematocrit levels have been identified including nutritional status, genetic disorders, and infections [ 36 , 37 ]. The disparity in the anaemia burden observed in the two cohorts of the subjects could be mainly attributed to variation in the malaria burden among the two cohorts.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Seasonal Malaria Chemoprevention on Malaria Burden among under Five-Year-Old Children in Borno State, Nigeria

Ambe

Balogun

Waziri

et al. 2020

Journal of Tropical Medicine

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Malaria disproportionately affects all ages with a high burden among children below five years. Thus, control measures are deployed including Seasonal Malaria Chemoprevention (SMC). The present study assessed the impacts of SMC on malaria burden among subjects aged 3–59 months in Borno State, Nigeria. Twenty (20) clusters were randomly selected from accessible 16 Local Government Areas (LGAs) of Borno State, Nigeria, and SMC was deployed in 10 of the clusters by administering a full dose of amodiaquine plus sulfadoxine-pyrimethamine at monthly intervals for 4 months consecutively. Three hundred and ninety-nine children were enrolled in the study. A structured questionnaire was used to obtain demographic and malaria-related data. Thick blood smear, thin blood smear, and capillary sample were collected two weeks after the 4th cycle of SMC. The prevalence of malaria and anaemia was determined among the subjects and for the clusters. The proportions of the female (46.4%; 185/399) and male (53.6%; 214/399) subjects were similar (p>0.05) with subjects aged 24–47 months (35.8%; 143/399) accounting for the highest proportion (p<0.05). Malaria prevalence was 10.3% (41/399) and was higher among non-SMC subjects (15.9%; 31/195) than among SMC subjects (4.9%; 10/204) (p<0.05, df = 1, χ2 = 10.8). Malaria prevalence was higher in non-SMC clusters (80.0%; 8/10) than in SMC clusters (30.0%; 3/10) (p<0.05, df = 1, χ2 = 40.5). The mean haematocrit of the 399 subjects was 34.0 ± 5.3% with an anaemia prevalence of 18.1% (72/399). The mean haematocrit was higher among SMC subjects (35.4 ± 5.0% vs. 33.1 ± 4.2%; p<0.05) while anaemia prevalence was higher among non-SMC subjects (21.5% vs. 14.6%; p<0.05, df = 1, χ2 = 2.8). Of the SMC subjects, 4.9% reported adverse drug reactions. SMC is safe and significantly reduced malaria burden among children in Borno State, and thus, the measure could be deployed in the state for effective malaria control.

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Section: Discussionmentioning

confidence: 99%

Impacts of Seasonal Malaria Chemoprevention on Malaria Burden among under Five-Year-Old Children in Borno State, Nigeria

Ambe

Balogun

Waziri

et al. 2020

Journal of Tropical Medicine

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“…As a possible pattern of malnutrition, we found an association among hematocrit level, low SCr level, and preoperative colonization. Malnutrition may induce anemia and as a consequence of that a low hematocrit level and a low SCr level could be considered as a proxy of protein‐energy wasting in some clinical situations . However, the sample size does not allow to verify this hypothesis.…”

Section: Discussionmentioning

confidence: 98%

Preoperative colonization in pediatric cardiac surgery and its impact on postoperative infections

Silvetti

Ranucci

Isgrò

et al. 2017

Pediatric Anesthesia

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“…Extrinsic causes occur in the external RBC environment, e.g. autoimmune hemolytic anemia, where antibodies directed towards RBCs are formed or infections causing hemolytic uremic syndrome where toxins lyse RBCs [1]. The treatment of these diseases would be to limit the hemolysis in patients, combined with blood transfusions.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis

Sellberg¹,

Fredriksson²,

Engstrand³

et al. 2019

PLoS ONE

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Background and objectivesThe objective of this study was to investigate whether a soluble polymer and aldehyde-scavenger, polyvinylalcohol-carbazate (PVAC), can inhibit hemolysis in the storage of red blood cells (RBC).Study design and methodsThe effect of PVAC was assessed over a wide range of concentrations, using absorption spectroscopy to evaluate the level of hemolysis. Moreover, osmotic stability and aldehyde-scavenging potential of RBC were assessed after storage in PVAC.ResultsAfter test tube storage for two weeks, red blood cell hemolysis was lower with PVAC compared to controls (mean difference 23%, 95% CI 16–29%, p < 0.001). A higher level of hemolysis led to a pronounced effect with PVAC. RBC stored in PVAC improved both the binding of free aldehydes (p <0.001) and the osmotic stability (p = 0.0036).ConclusionErythrocytes stored with PVAC showed less hemolysis, which might be explained by the ability of PVACs to stabilize the cell membrane and decrease oxidative injury.

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Anemias

Cited by 36 publications

References 30 publications

Impacts of Seasonal Malaria Chemoprevention on Malaria Burden among under Five-Year-Old Children in Borno State, Nigeria

Impacts of Seasonal Malaria Chemoprevention on Malaria Burden among under Five-Year-Old Children in Borno State, Nigeria

Preoperative colonization in pediatric cardiac surgery and its impact on postoperative infections

Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis

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