Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan  A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Hamaguchi, Sanae; Tsuchihashi-Makaya, Miyuki; Kinugawa, Shintaro; Yokota, Takashi; Takeshita, Akira; Yokoshiki, Hisashi; Tsutsui, Hiroyuki

doi:10.1253/circj.cj-09-0184

Cited by 80 publications

(49 citation statements)

References 55 publications

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“…Previous studies reported that 17-57% of patients admitted with HF had anemia (Horwich et al 2002;Ezekowitz et al 2003;Hamaguchi et al 2009;Caira et al 2013). In the present clinical study, the observed rate of anemia in consecutive HF patients admitted to the Cardiovascular Disease Department of Niigata University Medical and Dental Hospital was 41%, which agreed with the previous reports.…”

Section: Anemia and Hepcidin In Hf Patientssupporting

confidence: 92%

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Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia

Ohno¹,

Hanawa²,

Jiao³

et al. 2015

Tohoku J. Exp. Med.

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Hepcidin is a key regulator of mammalian iron metabolism and mainly produced by the liver. Hepcidin excess causes iron deficiency and anemia by inhibiting iron absorption from the intestine and iron release from macrophage stores. Anemia is frequently complicated with heart failure. In heart failure patients, the most frequent histologic appearance of liver is congestion. However, it remains unclear whether liver congestion associated with heart failure influences hepcidin production, thereby contributing to anemia and functional iron deficiency. In this study, we investigated this relationship in clinical and basic studies. In clinical studies of consecutive heart failure patients (n = 320), anemia was a common comorbidity (41%). In heart failure patients without active infection and ongoing cancer (n = 30), log-serum hepcidin concentration of patients with liver congestion was higher than those without liver congestion (p = 0.0316). Moreover, in heart failure patients with liver congestion (n = 19), the anemia was associated with the higher serum hepcidin concentrations, which is a type of anemia characterized by induction of hepcidin. Subsequently, we produced a rat model of heart failure with liver congestion by injecting monocrotaline that causes pulmonary hypertension. The monocrotaline-treated rats displayed liver congestion with increase of hepcidin expression at 4 weeks after monocrotaline injection, followed by anemia and functional iron deficiency observed at 5 weeks. We conclude that liver congestion induces hepcidin production, which may result in anemia and functional iron deficiency in some patients with heart failure.

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Section: Anemia and Hepcidin In Hf Patientssupporting

confidence: 92%

“…Anemia frequently occurs in patients with heart failure (HF) and is an independent prognostic factor for mortality (Ezekowitz et al 2003;Hamaguchi et al 2009). The etiology of anemia in HF patients is thought to be multifactorial.…”

Section: Introductionmentioning

confidence: 99%

Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia

Ohno¹,

Hanawa²,

Jiao³

et al. 2015

Tohoku J. Exp. Med.

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show abstract

“…29 Anemia, occurring in as much as 56.7% of cases of chronic heart failure in Japan, has proven to be an independent risk factor for all-cause mortality, cardiac death, and readmission for exacerbation of heart failure. 30 Therefore, drug-induced anemia should not be neglected in cardiovascular outpatients, who are often at high risk of heart failure. Accumulation of iron in excess has been implicated in the risk of cardiovascular disease or cancer through increased iron catalyzed free radical-mediated oxidative stress.…”

Section: Decrease In Hb After Initiation Of Ppimentioning

confidence: 99%

Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients

Shikata

Sasaki

Ueda

et al. 2014

Circ J

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“…12, [13][14][15] The JCARE-CARD program enrolled 2,675 patients admitted with HF in a web-based registry at 164 participating hospitals with an average follow-up of 2.2 years. The present study was aimed to analyze the JCARE-CARD database to evaluate the relationship between discharge use of β-blockers and long-term clinical outcomes using by the regression adjustment for the propensity score, which is a statistical method that reduces confounding and bias from measured variables in observational data.…”

mentioning

confidence: 99%

Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival

Tsuchihashi-Makaya

Kinugawa

Yokoshiki

et al. 2010

Circ J

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Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan A Report From the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Cited by 80 publications

References 55 publications

Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia

Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia

Use of Proton Pump Inhibitors Is Associated With Anemia in Cardiovascular Outpatients

Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival

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