Anemia in severe acute malnutrition

Thakur, Neha; Chandra, Jagdish; Pemde, Harish; Singh, Varinder

doi:10.1016/j.nut.2013.09.011

Cited by 67 publications

(64 citation statements)

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“…67.3% of these had severe anemia and 13.8% had moderate anemia. 24 In another Indian study by R. Kumar et al (Madhya Pradesh, 2013) 88.5% children had anemia, 7.6% had mild anemia, 55.7 % had moderate anemia and 24% had severe anemia. 25 in a study done by Ubesie et al (in Nigeria 2012), they found severe anemia in 24.2% of the patients with PEM.…”

Section: Discussionmentioning

confidence: 94%

“…In their study, Thakur et al got the most common type of anemia as microcytic (38.6%) followed by megaloblastic (30.5%). 24 …”

Section: Discussionmentioning

confidence: 99%

“…In this regard more studies are needed. As megaloblastic anemia closely follows microcytic anemia, supplementation with vitamin B12 in addition to iron and folic acid may be recommended as was suggested by Thakur et al (2014). Most of the children in PEM group suffer from moderate to severe anemia.…”

Section: Discussionmentioning

confidence: 99%

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A Case Control Study of Hematological Changes in Children with Protein Energy Malnutrition Attending Gauhati Medical College and Hospital.

Gohain¹,

Pathak²,

Choudhury³

2016

IOSR

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Section: Discussionmentioning

confidence: 94%

“…In their study, Thakur et al got the most common type of anemia as microcytic (38.6%) followed by megaloblastic (30.5%). 24 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Control Study of Hematological Changes in Children with Protein Energy Malnutrition Attending Gauhati Medical College and Hospital.

Gohain¹,

Pathak²,

Choudhury³

2016

IOSR

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“…Furthermore, the frequency and percentage of CD4 + and CD8 + T cells were similar in the malnourished healthy individuals and those with normal BMI. Little is known about haematological profiles in malnourished individuals, the main body of the work done in this area was performed in children and some studies have shown that anaemia [37, 38] can be associated with malnutrition. In addition, studies of the haematological data from patients with anorexia nervosa have also shown that anaemia and mild neutropenia are found in some patients [39, 40].…”

Section: Discussionmentioning

confidence: 99%

Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function

et al. 2016

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Malnutrition is commonly associated with increased infectious disease susceptibility and severity. Whereas malnutrition might enhance the incidence of disease as well as its severity, active infection can in turn exacerbate malnutrition. Therefore, in a malnourished individual suffering from a severe infection, it is not possible to determine the contribution of the pre-existing malnutrition and/or the infection itself to increased disease severity. In the current study we focussed on two groups of malnourished, but otherwise healthy individuals: moderately malnourished (BMI: 18.4–16.5) and severely malnourished (BMI <16.5) and compared several immune parameters with those of individuals with a normal BMI (≥18.5). Our results show a similar haematological profile in all three groups, as well as a similar ratio of CD4+ and CD8+ T cells. We found significant correlations between low BMI and increased levels of T helper (Th) 1 (Interferon (IFN)-γ, (interleukin (IL)-2, IL-12), Th2 (IL-4, IL-5, IL-13), as well as IL-10, IL-33 and tumor necrosis factor-α, but not IL-8 or C reactive protein. The activities of arginase, an enzyme associated with immunosuppression, were similar in plasma, peripheral blood mononuclear cells (PBMC) and neutrophils from all groups and no differences in the expression levels of CD3ζ, a marker of T cell activation, were observed in CD4+ and CD8+T cells. Furthermore, whereas the capacity of neutrophils from the malnourished groups to phagocytose particles was not impaired, their capacity to produce reactive oxygen species was impaired. Finally we evaluated the frequency of a subpopulation of low-density neutrophils and show that they are significantly increased in the malnourished individuals. These differences were more pronounced in the severely malnourished group. In summary, our results show that even in the absence of apparent infections, healthy malnourished individuals display dysfunctional immune responses that might contribute to increased susceptibility and severity to infectious diseases.

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“…5,6 Acute malnutrition with severe anemia may require hospitalization and blood transfusion. 7 Hospitalized and critical care unit patients especially patients that are from communities having inadequate resources are often found to have malnourishment. [8][9][10] They are found in 13-78% admitted to acute care settings.…”

Section: Introductionmentioning

confidence: 99%

Nutritional dermatoses and its association with anemia and systemic illness

Lakhani

Surti

Doshi³

et al. 2018

Int J Res Dermatol

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Background: Mucocutaneous changes may be a "tell-tale" signs of multi nutrional deficiency including anemia. Some are very characteristic of a specific nutrient deficiency, while other signs may overlap and will reflect multiple deficiency states. Methods: To scrutinize clinical signs of multi nutritional deficiencies accompanied with anemia, this observational clinical study of 75 patients (adult and adolescents) was undertaken. Patients were selected from out-patient and inpatient department (OPD and IPD) of dermatology as well as General Medicine ward including medical ICU. Relevant investigations were carried out whenever required. Detail clinical history of diet, tuberculosis as well as HIV disease, worm infestation, other co-morbid conditions and alcohol intake were taken. Clinical signs of nutritional deficiencies like of pellagra, kwashiorkor, beriberi, ariboflavinosis and other signs of avitaminosis and micronutrient deficiency were looked for in all such patients. Results: Of 75 patients, 37 were male (M) and 38 female (F). One of the important findings was that one third patients were admitted in ICU and in 60 of 75 patients risk factors could be identified. Mental illness, ICU admission, elderly age, systemic illness and alcohol consumption were the predisposing factors. Iron deficiency anemia was the commonest anemia followed by dimorphic anemia with other multinutrional manifestations. Clinical signs which were observed due to multinutritional deficiency were of pellagra dermatosis, kwashiorkor, koilonychia with pale tongue and mucous membranes, angular cheilosis, hair changes of various types and other signs due to systemic involvement. Conclusions: Anemia may be associated with other nutritional abnormality which is reflected in changes in the skin, mucous membrane, hairs and nails. Nutritional dermatosis and anemia can be part of systemic illness which maybe reflected as deficiency of multiple nutritive factors.

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Anemia in severe acute malnutrition

Cited by 67 publications

References 1 publication

A Case Control Study of Hematological Changes in Children with Protein Energy Malnutrition Attending Gauhati Medical College and Hospital.

A Case Control Study of Hematological Changes in Children with Protein Energy Malnutrition Attending Gauhati Medical College and Hospital.

Malnutrition in Healthy Individuals Results in Increased Mixed Cytokine Profiles, Altered Neutrophil Subsets and Function

Nutritional dermatoses and its association with anemia and systemic illness

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