Anemia in Celiac Disease: Multiple Aspects of the Same Coin

Kokoris, Styliani; Gavriilaki, Eleni; Vrigkou, Eleni; Triantafyllou, Konstantinos; Roumeliotou, Anna; Kyriakou, Elias; Lada, Evangelia; Gialeraki, Argyri; Kalantzis, Dimitrios; Grouzi, Elisavet

doi:10.1159/000527463

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Although anemia is quite common in CD, posing a problem if it is a symptom or a complication of the disease [ 7 ], the literature data on the coexistence of CD and allergies are rather scarce.…”

Section: Introductionmentioning

confidence: 99%

IgE-Dependent Allergy in Patients with Celiac Disease: A Systematic Review

Majsiak

Choina²,

Knyziak-Mędrzycka

et al. 2023

Nutrients

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In order to answer the question if an IgE-mediated allergy (A-IgE) may occur in subjects with celiac disease (CD), a systematic review was performed of available publications collected in the United States National Institute for Biotechnology Information/National Institutes of Health/National Library of Medicine/PubMed database up to 28 December 2022, with the use of the following keywords “allergy&celiac/coeliac”, “sensitization&celiac/coeliac”, and “anaphylaxis&celiac/coeliac” compared in the form of a conjunction. In total, the search returned 2013 publications from these keywords in any section of the article. As numerous review articles included the above-mentioned entries in the abstract, we decided to focus on the publications with the entries only in the title (n = 63). After rejecting studies unrelated to the topic, narrative reviews, book chapters, conference abstracts, symposium reports, letters to the editor, or non-English articles, 18 publications (6 observational original studies and 12 case reports describing a total of 15 cases of A-IgE developed after a diagnosis of CD) were included to this review. Our study is the first systematic review on allergy occurrence in CD patients. The analysis indicated that the possibility of a coexistence of A-IgE with any food and inhalant allergens in subjects diagnosed with CD should be considered. A sensitization to wheat was the most frequently described in subjects with CD. The clinical manifestation of A-IgE in CD was similar to that in subjects without CD; e.g., with possible atopic dermatitis, vomiting, urticaria, angioedema, or anaphylactic shock. Screening for allergies in subjects with CD should be considered, especially in those cases where symptoms persist after introducing a gluten-free diet. The elimination of wheat from the diet of patients with CD may lead to a loss of immune tolerance and to the development of sensitization, which may even manifest as anaphylaxis. In conclusion, although there are few studies assessing the occurrence of A-IgE in subjects with CD, they show the possibility of a coexistence of both diseases and the high clinical significance of this phenomenon, which indicates the need for further studies.

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Section: Introductionmentioning

confidence: 99%