Anemia en las embarazadas de la comuna de Puente Alto, Chile

S, Francisco Mardones; R, Alonso Rioseco; T, Mauricio Ocqueteau; S, María Teresa Urrutia; G, Lorena Javet; T, Iván Rojas; P, Luis Villarroel del

doi:10.4067/s0034-98872003000500007

Cited by 8 publications

(4 citation statements)

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“…Although not statistically significant, we did observe a trend in the difference in the frequency of smoking among cases (10.9%) and controls (14.2%) in the direction of a protective effect of smoking. In another published study of patients attending prenatal clinics in Puente Alto, Chile, the reported frequency of smoking was 11.88% at the beginning of pregnancy [72] , which is exactly the same population as the one included in our study. In a study performed by the Ministry of Health of Chile in 1985, the frequency of smoking at the beginning of pregnancy was 20.2% [73] .…”

Section: Multiple Testing Correctionmentioning

confidence: 60%

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

et al. 2006

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Pre-eclampsia (PE) affects 5–7% of pregnancies in the US, and is a leading cause of maternal death and perinatal morbidity and mortality worldwide. To identify genes with a role in PE, we conducted a large-scale association study evaluating 775 SNPs in 190 candidate genes selected for a potential role in obstetrical complications. SNP discovery was performed by DNA sequencing, and genotyping was carried out in a high-throughput facility using the MassARRAY^TM System. Women with PE (n = 394) and their offspring (n = 324) were compared with control women (n = 602) and their offspring (n = 631) from the same hospital-based population. Haplotypes were estimated for each gene using the EM algorithm, and empirical p values were obtained for a logistic regression-based score test, adjusted for significant covariates. An interaction model between maternal and offspring genotypes was also evaluated. The most significant findings for association with PE were COL1A1 (p = 0.0011) and IL1A (p = 0.0014) for the maternal genotype, and PLAUR (p = 0.0008) for the offspring genotype. Common candidate genes for PE, including MTHFR and NOS3, were not significantly associated with PE. For the interaction model, SNPs within IGF1 (p = 0.0035) and IL4R (p = 0.0036) gave the most significant results. This study is one of the most comprehensive genetic association studies of PE to date, including an evaluation of offspring genotypes that have rarely been considered in previous studies. Although we did not identify statistically significant evidence of association for any of the candidate loci evaluated here after adjusting for multiple testing using the false discovery rate, additional compelling evidence exists, including multiple SNPs with nominally significant p values in COL1A1 and the IL1A region, and previous reports of association for IL1A, to support continued interest in these genes as candidates for PE. Identification of the genetic regulators of PE may have broader implications, since women with PE are at increased risk of death from cardiovascular diseases later in life.

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Section: Multiple Testing Correctionmentioning

confidence: 60%

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

et al. 2006

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“…For the last 6 years Chile has been supplying these two micronutrients, i.e. folic acid and iron, to the general population of pregnant women through the fortification of white flour and the delivery of ferrous sulphate tablets, respectively 10,11 . Therefore, the possible impact of a combination of multiple micronutrients can be further explored as public programmes already provide folic acid and iron.…”

mentioning

confidence: 99%

Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women

Mardones

Villarroel

et al. 2008

Public Health Nutr.

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Objective: To test the hypothesis that maternal food fortification with omega-3 fatty acids and multiple micronutrients increases birth weight and gestation duration, as primary outcomes. Design: Non-blinded, randomised controlled study. Setting: Pregnant women received powdered milk during their health check-ups at 19 antenatal clinics and delivered at two maternity hospitals in Santiago, Chile. Subject: Pregnant women were assigned to receive regular powdered milk (n 5 477) or a milk product fortified with multiple micronutrients and omega-3 fatty acids (n 5 495). Results: Intention-to-treat analysis showed that mean birth weight was higher in the intervention group than in controls (65.4 g difference, 95% confidence interval (CI) 5-126 g; P 5 0.03) and the incidence of very preterm birth (,34 weeks) was lower (0.4% vs. 2.1%; P 5 0.03). On-treatment analysis showed a mean birth weight difference of 118 g (95% CI 47-190 g; P 5 0.001) and a relative fall in both the proportion of birth weight #3000 g (P 5 0.015) and the incidence of preeclampsia (P 5 0.015). Compliance with the experimental product was apparent from a haematological study of red-blood-cell folate at the end of pregnancy, which was performed in a sub-sample. In both types of analyses, positive differences were also present for mean gestation duration, birth length and head circumference. Nevertheless, the relatively small sample sizes allowed a statistical power of .0.80 just for mean birth weight and birth length in the on-treatment analysis; birth length in that analysis had a difference of 0.57 cm (95% CI 0.19-0.96 cm; P 5 0.003). Conclusions:The new intervention resulted in increased mean birth weight. Associations with gestation duration and most secondary outcomes need a larger sample size for confirmation.

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“…Los promedios en las características de este grupo de mujeres al inicio del embarazo resultan ser muy similares a las publicadas recientemente sobre las embarazadas de la comuna de Puente Alto y la ciudad de Concepción 12,13 . En cuanto a los promedios de datos del parto y del recién nacido que provee el sistema de salud chileno y que fueron utilizados en este estudio, se puede decir que son considerados de cobertura prácticamente completa de la población y altamente confi ables, según lo indicado en varias publicaciones realizadas en los últimos años dentro y fuera del país 7,8,[14][15][16][17][18] .…”

Section: Discussionunclassified

Influencia combinada del índice de masa corporal pregestacional y de la ganancia de peso en el embarazo sobre el crecimiento fetal

et al. 2011

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Anemia en las embarazadas de la comuna de Puente Alto, Chile

Cited by 8 publications

References 0 publications

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

Candidate-Gene Association Study of Mothers with Pre-Eclampsia, and Their Infants, Analyzing 775 SNPs in 190 Genes

Effects of a dairy product fortified with multiple micronutrients and omega-3 fatty acids on birth weight and gestation duration in pregnant Chilean women

Influencia combinada del índice de masa corporal pregestacional y de la ganancia de peso en el embarazo sobre el crecimiento fetal

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