Anemia during lung cancer

Souilah, S.; Dermech, N.; Benbetka, Y.; Djami, Nassima; Khennouf, K.; Amrane, R.; Fissah, A.

doi:10.1183/13993003.congress-2018.pa2822

Cited by 2 publications

(3 citation statements)

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“…The reticulocyte count is one of the primary parameters used in the initial classification of anemia, which co-occurs with lung cancer at baseline and is often exacerbated after chemotherapy treatment (52). The prevalence of anemia in patients with lung cancer is 37.6% and its incidence after chemotherapy treatment is 80% (53).…”

Section: Discussionmentioning

confidence: 99%

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies

Byun

Han

Ostrom

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Prior genome-wide association studies have identified numerous lung cancer risk loci and reveal substantial etiologic heterogeneity across histologic subtypes. Analyzing the shared genetic architecture underlying variation in complex traits can elucidate common genetic etiologies across phenotypes. Exploring pairwise genetic correlations between lung cancer and other polygenic traits can reveal the common genetic etiology of correlated phenotypes. Methods: Using cross-trait linkage disequilibrium score regression, we estimated the pairwise genetic correlation and heritability between lung cancer and multiple traits using publicly available summary statistics. Identified genetic relationships were also examined after excluding genomic regions known to be associated with smoking behaviors, a major risk factor for lung cancer. Results: We observed several traits showing moderate single nucleotide polymorphism–based heritability and significant genetic correlations with lung cancer. We observed highly significant correlations between the genetic architectures of lung cancer and emphysema/chronic bronchitis across all histologic subtypes, as well as among lung cancer occurring among smokers. Our analyses revealed highly significant positive correlations between lung cancer and paternal history of lung cancer. We also observed a strong negative correlation with parental longevity. We observed consistent directions in genetic patterns after excluding genomic regions associated with smoking behaviors. Conclusions: This study identifies numerous phenotypic traits that share genomic architecture with lung carcinogenesis and are not fully accounted for by known smoking-associated genomic loci. Impact: These findings provide new insights into the etiology of lung cancer by identifying traits that are genetically correlated with increased risk of lung cancer.

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Section: Discussionmentioning

confidence: 99%

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies

Byun

Han

Ostrom

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The proportion of paraneoplastic anemia in this study was 40.4%, with an average Hb of 12.4 g/dL, and the most common type was normocytic normochromic anemia (50%). Souilah, et al (2018) reported that the proportion of anemia was about 33.7%, with a mean Hb of 12.4 g/dL. 21 A higher proportion was obtained by Baburao, et al (2015) in Bangalore (61.5%).…”

Section: Paraneoplastic Anemiamentioning

confidence: 98%

“…Souilah, et al (2018) reported that the proportion of anemia was about 33.7%, with a mean Hb of 12.4 g/dL. 21 A higher proportion was obtained by Baburao, et al (2015) in Bangalore (61.5%). 16 About 53% of subjects with paraneoplastic anemia had malnutrition.…”

Section: Paraneoplastic Anemiamentioning

confidence: 98%

Hematologic Paraneoplastic Syndrome in Newly Diagnosed Patients with Lung Cancer

Putra

Jonathan

Winardi

et al. 2023

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Introduction: Lung cancer could have signs and symptoms generated by paraneoplastic syndromes. This study aimed to describe and analyze hematologic paraneoplastic syndrome in patients with lung cancer in Indonesia. Methods: This was a cross-sectional analytic study conducted in Persahabatan National Respiratory Referral Hospital, Jakarta, between September 2018 and February 2019, on all newly diagnosed patients with lung cancer whose diagnosis was established and who fulfilled the inclusion and exclusion criteria. Results: The mean age of subjects was 56.7 ± 11.4 years old. Most subjects were male, had normal nutritional status (42.6%), had a smoking history (75%), and had a moderate Brinkman Index (BI) value (52%). The most common type of histology was squamous cell carcinoma (SCC) (39.7%), with advanced stage (83.8%) and performance status <2 (94.1%). Paraneoplastic anemia was 40.4%, associated with poor nutritional status and commonly normocytic normochromic anemia. The proportion of paraneoplastic leukocytosis was 39%, associated with males and smoking history. The proportion of paraneoplastic neutrophilia was 51.5%, and it was related to males, smoking history, and SCC histology type. Paraneoplastic hypereosinophilia and thrombocytosis proportions were 2.9% and 18.4%, respectively. The proportion of paraneoplastic hypercoagulability was 91.2%, which was caused by the elevated D-dimer level. Conclusion: The most common hematologic paraneoplastic syndromes in patients with lung cancer were hypercoagulability, neutrophilia, and anemia. The low hemoglobin (Hb) level of paraneoplastic anemia was associated with low body mass index (BMI). Male and smoking history in lung cancer patients were associated with paraneoplastic leukocytosis and/or neutrophilia.

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Anemia during lung cancer

Cited by 2 publications

References 0 publications

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies

Hematologic Paraneoplastic Syndrome in Newly Diagnosed Patients with Lung Cancer

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