Anemia: Diagnosis and Management

Coyer, Sharon M.

doi:10.1016/j.pedhc.2005.07.014

Cited by 18 publications

(14 citation statements)

References 14 publications

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“…MCV has been used to guide the diagnosis of anemia in patients, for example, testing patients with microcytic anemia for iron deiciency or thalassemia and those with macrocytic anemia for deiciency of folate or vitamin B 12 [4,15].…”

Section: Mean Corpuscular Volume (Mcv)mentioning

confidence: 99%

“…In situations such as sideroblastic anemia, recently transfused patients, patients with severe pernicious anemia with red blood cell fragmentation, and in conditions where both folate and iron deiciency are present, both large and small red blood cells are observed, which compromise the value of MCV. When present in signiicant numbers, they will cause MCHC to increase to levels in excess of 36 g/dL [4,6,15].…”

Section: Mean Corpuscular Hemoglobin Concentration (Mchc)mentioning

confidence: 99%

“…A second method of measuring the RDW is RDW-SD and is independent of MCV. RDW-SD is measured by calculating the width at the 20% height level of the red blood cell size distribution histogram (normal RDW-SD = 42 ± 5 fL) [6,8,15].…”

Section: Red Blood Cell Distribution Width (Rdw)mentioning

confidence: 99%

“…The reticulocyte count can be used in diferentiation of the patients with a functionally normal marrow response to anemia/hypoxia and those with a failed marrow response. Whenever the reticulocyte production index (RPI) increases to levels greater than three times normal in response to an anemia (hematocrit <30%), it can be assumed that the patient has normal renal function with an appropriate erythropoietin response and a normal erythroid marrow with an adequate supply of key nutrients (iron, folic acid, and vitamin B 12 ) [6,15]. Sickle cell Elongated cell with pointed ends.…”

Section: Reticulocyte Countmentioning

confidence: 99%

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Laboratory Approach to Anemia

Yenilmez¹,

Tuli²

2018

Current Topics in Anemia

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Anemia is a major cause of morbidity and mortality worldwide and can be deined as a decreased quantity of circulating red blood cells (RBCs). The epidemiological studies suggested that one-third of the world's population is afected with anemia. Anemia is not a disease, but it is instead the sign of an underlying basic pathological process. However, the sign may function as a compass in the search for the cause. Therefore, the prediagnosis revealed by thorough investigation of this sign should be supported by laboratory parameters according to the underlying pathological process. We expect that this review will provide guidance to clinicians with indings and laboratory tests that can be followed from the initial stage in the anemia search.

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Section: Mean Corpuscular Volume (Mcv)mentioning

confidence: 99%

Section: Mean Corpuscular Hemoglobin Concentration (Mchc)mentioning

confidence: 99%

Section: Red Blood Cell Distribution Width (Rdw)mentioning

confidence: 99%

Section: Reticulocyte Countmentioning

confidence: 99%

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Laboratory Approach to Anemia

Yenilmez¹,

Tuli²

2018

Current Topics in Anemia

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“…2 The highest incidence of iron deficiency anemia is seen in children between 9 and 24 months of age due to their rapid growth, although it involves school children and preadolescents to a lesser extent too. [3][4][5] Adults' body content of iron is much more than infants', to make up this discrepancy, an average of 0.8 mg of iron must be absorbed each day during the first 15 years of life. 3 An iron-poor diet or an iron loss which precedes its intake will deplete the iron stores presented at birth within 6 months in full-term infants and as early as 3 to 4 months in premature infants.…”

mentioning

confidence: 99%

Supplemental food may not prevent iron-deficiency anemia in infants

et al. 2008

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Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias

Bush

Choi

et al. 2021

American J Hematol

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Anemia is the most common blood disorder in the world. In patients with chronic anemia, such as sickle cell disease or major thalassemia, cerebral blood flow increases to compensate for decreased oxygen content. However, the effects of chronic anemia on oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO 2 ) are less well understood. In this study, we examined 47 sickle-cell anemia subjects (age 21.7 ± 7.1, female 45%), 27 non-sickle anemic subjects (age 25.0 ± 10.4, female 52%) and 44 healthy controls (age 26.4 ± 10.6, female 71%) using MRI metrics of brain oxygenation and flow. Phase contrast MRI was used to measure resting cerebral blood flow, while T 2 -relaxation-under-spin-tagging (TRUST) MRI with disease appropriate calibrations were used to measure OEF and CMRO 2 . We observed that patients with sickle cell disease and other chronic anemias have decreased OEF and CMRO 2 (respectively 27.4 ± 4.1% and 3.39 ± 0.71 ml O 2 /100 g/ min in sickle cell disease, 30.8 ± 5.2% and 3.53 ± 0.64 ml O 2 /100 g/min in other anemias) compared to controls (36.7 ± 6.0% and 4.00 ± 0.65 ml O 2 /100 g/min). Impaired CMRO 2 was proportional to the degree of anemia severity. We further demonstrate striking concordance of the present work with pooled historical data from patients having broad etiologies for their anemia. The reduced cerebral oxygen extraction and metabolism are consistent with emerging data demonstrating increased non-nutritive flow, or physiological shunting, in sickle cell disease patients.Ms. Vu and Dr. Bush contributed equally and are designated as co-first authors.

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Anemia: Diagnosis and Management

Cited by 18 publications

References 14 publications

Laboratory Approach to Anemia

Laboratory Approach to Anemia

Supplemental food may not prevent iron-deficiency anemia in infants

Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias

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