Anemia and retinal function in a mouse model of acute colitis

Watts, Megan N.

doi:10.1016/j.pathophys.2014.08.001

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…ERGO is taken up into the hematopoietic progenitor cells and exhibits high distribution to red blood cells possibly due to maturation of the progenitor cells [10,36]. It was previously reported that the hematocrit levels in IBD patients and DSS-treated mice were decreased [37,38]. However, ERGO concentration was reduced in both blood and plasma of DSStreated mice (Fig.…”

Section: Discussionmentioning

confidence: 86%

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

Shimizu

Masuo

Takahashi

et al. 2015

Drug Metabolism and Pharmacokinetics

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Section: Discussionmentioning

confidence: 86%

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

Shimizu

Masuo

Takahashi

et al. 2015

Drug Metabolism and Pharmacokinetics

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“…The DSS model of induced colitis is considered a good preclinical model that exhibits many phenotypic features of relevance to human IBD [ 55 – 58 ]. DSS mice have increased anxiety-like behavior [ 59 ] and decreased electroretinography amplitudes, a measurement of retinal function [ 60 ], suggestive of two common extraintestinal manifestations. Our findings indicate that the DSS rat model could be a useful tool for mechanistic elucidation of cardiovascular diseases in IBD.…”

Section: Discussionmentioning

confidence: 99%

Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart

et al. 2021

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Ulcerative colitis and Crohn’s disease are classified as chronic inflammatory bowel diseases (IBD) with known extraintestinal manifestations. The interplay between heart and gut in IBD has previously been noted, but the mechanisms remain elusive. Our objective was to identify microRNAs mediating molecular remodeling and resulting cardiac impairment in a rat model of colitis. To induce chronic colitis, dextran sodium sulfate (DSS) was given to adult rats for 5 days followed by 9 days with normal drinking water for 4 cycles over 8 weeks. Echocardiography was performed to evaluate heart function. DSS-induced colitis led to a significant decrease in ejection fraction, increased left ventricular mass and size, and elevated B-type natriuretic protein. MicroRNA profiling showed a total of 56 miRNAs significantly increased in the heart by colitis, 8 of which are predicted to target brain-derived neurotrophic factor (BDNF). RT-qPCR validated the increases of miR-1b, Let-7d, and miR-155. Transient transfection revealed that miR-155 significantly suppresses BDNF in H9c2 cells. Importantly, DSS colitis markedly decreased BDNF in both myocardium and serum. Levels of various proteins critical to cardiac homeostasis were also altered. Functional studies showed that BDNF increases cell viability and mitigates H2O2-induced oxidative damage in H9c2 cells, demonstrating its protective role in the adult heart. Mechanistically, cellular experiments identified IL-1β as the inflammatory mediator upregulating cardiac miR-155; this effect was confirmed in adult rats. Furthermore, IL-1β neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential. Our findings indicate that chronic colitis impairs heart function through an IL-1β→miR-155→BDNF signaling axis.

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MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells

et al. 2021

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Anemia and retinal function in a mouse model of acute colitis

Cited by 4 publications

References 22 publications

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice

Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart

MAdCAM-1 mediates retinal neuron degeneration in experimental colitis through recruiting gut-homing CD4+ T cells

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