Anemia and Poor Iron Indices Are Associated With Susceptibility to Febrile Seizures in Children: A Systematic Review and Meta-analysis

Sulviani, Rini; Kamarullah, William; Dermawan, Sherly; Susanto, Helen

doi:10.1177/08830738231170333

Cited by 2 publications

(2 citation statements)

References 35 publications

(46 reference statements)

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“…Recent studies report that gross motor and adaptability development is negatively correlated with IDA in infants and toddlers, especially attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) [66,67]. A higher susceptibility to febrile seizures in children with ID and IDA has also been determined in a large number of case-control studies [68]. Not only does IDA adversely affect development and growth, but it might also contribute to hypercoagulability due to oxidative stress, endangering young patients with thromboembolic events [69,70].…”

Section: Discussionmentioning

confidence: 99%

Management of Childhood Iron Deficiency Anemia in a Developed Country—A Multi-Center Experience from Croatia

Kranjčec,

Matijašić Stjepović,

Buljan

et al. 2023

Diagnostics

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Iron deficiency anemia (IDA) continues to be a global public health concern, mostly in the developing countries. However, precise epidemiological data on childhood IDA in Croatia are lacking. In order to establish its frequency, underlying etiologies, the rationale for tertiary care visits, diagnostic practices, and current treatment regimens of IDA, medical records of children referred to pediatric hematologists for iron deficiency in a five-year period at tertiary institutions (Zagreb, Rijeka, Split, Osijek) throughout Croatia were retrospectively analyzed. Eight hundred and sixty-four children, predominately of preschool age, were referred mainly by the primary care pediatricians, who, in general, performed basic diagnostics but failed to initiate oral iron therapy in half of the patients. Approximately one-third of patients were symptomatic, with inadequate nutrition prevailing as underlying etiology. Dextriferron was the preferred iron formulation among hematologists, with a median dose of 5 mg/kg, with acceptable compliance rates (63.5–93.2%). Hospital admission rates varied among the centers (9.4–35%), and so did transfusion policies (6.4–22.9%). The greatest difference was observed in the frequency of parenteral iron administration (0.3–21.5%). In conclusion, the burden of childhood IDA, even in a high-income country, remains substantial, necessitating consistent implementation of national guidelines and additional education of primary health care providers.

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Section: Discussionmentioning

confidence: 99%

Management of Childhood Iron Deficiency Anemia in a Developed Country—A Multi-Center Experience from Croatia

Kranjčec,

Matijašić Stjepović,

Buljan

et al. 2023

Diagnostics

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“…A meta-analysis of 20 case-control studies demonstrated that there is an association between ID and an increased risk of febrile seizures in children [47] . Additionally, another study revealed that mean ferritin levels were lower in children with a first episode of febrile seizures than in the febrile control group [48].…”

Section: One Of the Well-known Pathophysiological Mechanisms Of Atten...mentioning

confidence: 99%

Long-term Effects of Iron Deficiency in Early Infancy on Neurodevelopment

Korczak,

Wójcik,

Olek

et al. 2024

J Educ Health Sport

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Introduction and Purpose: Iron deficiency alongside anaemia is one of the most significant global health concerns with potentially long-lasting implications on child development and health outcomes. The period of infancy represents a crucial phase of central nervous system maturation, rendering infants particularly susceptible to the adverse effects of iron deficiency. It is therefore crucial to pay close attention to this issue. The aim of this review is to elucidate the neurological implications of iron deficiency in infancy and emphasize the necessity of implementing preventive strategies to safeguard child development. State of Knowledge: Iron deficiency in infancy can result in impairments of brain development. Extensive research highlights the influence of this micronutrient on various physiological processes, including the synthesis of neurotransmitters, neuronal metabolism, myelination, synaptogenesis and gene expression. Furthermore, iron deficiency during infancy is associated with adverse developmental outcomes, including cognitive, motor, and socioemotional deficits. Long-term follow-up studies have elucidated the enduring neurological consequences of iron deficiency in infancy, with effects extending into childhood and beyond. Summary: Given that the changes that occur during the infantile period are often irreversible and have long-lasting implications for future development, it is of the utmost importance to prioritize prevention strategies.

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Anemia and Poor Iron Indices Are Associated With Susceptibility to Febrile Seizures in Children: A Systematic Review and Meta-analysis

Cited by 2 publications

References 35 publications

Management of Childhood Iron Deficiency Anemia in a Developed Country—A Multi-Center Experience from Croatia

Management of Childhood Iron Deficiency Anemia in a Developed Country—A Multi-Center Experience from Croatia

Long-term Effects of Iron Deficiency in Early Infancy on Neurodevelopment

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