Anemia and neutropenia associated with copper deficiency of unclear etiology

Harless, William; Crowell, Edward B.; Abraham, Jame

doi:10.1002/ajh.20647

Cited by 44 publications

(28 citation statements)

References 14 publications

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“…However, some authors have suggested that copper enzymes are critical to the maturation of hematopeietic cells and copper deficiency can impair effective iron utilization. Our study noted that there is a higher frequency of copper deficiency in anemia [34].…”

Section: Statisticssupporting

confidence: 59%

Estimation of Serum Copper and Zinc in Anaemic Patients

Swaminathan

Parveen²,

Vishnupriya³

et al. 2016

Asian J Pharm Clin Res

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Objective: Estimation of serum zinc and copper levels in anemic patients. Methods:The study design included 30 subjects presenting to clinical laboratory, global hospitals. The subjects were divided into 2 groups. The Group 1 consists of 15 healthy individuals and Group 2 consists of 15 anemic patients. Results:The serum copper and zinc levels were evaluated in anemic patients. The serum copper and zinc were found to be significantly lower in anemic patients when compared with normal individuals.

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Section: Statisticssupporting

confidence: 59%

Estimation of Serum Copper and Zinc in Anaemic Patients

Swaminathan

Parveen²,

Vishnupriya³

et al. 2016

Asian J Pharm Clin Res

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“…Iron stores are characteristically increased with prominent ringed sideroblasts. These findings can be mistaken for a myelodysplastic syndrome [31]. Morphologic findings characteristic of MDS in the marrow include vacuolization of erythroid precursors, abnormal nuclear lobulation of both erythroid and myeloid precursors, nuclear/cytoplasmic dyssynchrony of erythroid precursors, and dysmegakaryopoiesis with abnormalities of nuclear lobulation and size [25, 27].…”

Section: Bone Marrow Findings After Gastric Bypass Surgery Mimickimentioning

confidence: 99%

Hematological Disorders following Gastric Bypass Surgery: Emerging Concepts of the Interplay between Nutritional Deficiency and Inflammation

Chen

Krishnamurthy

Mohamed

et al. 2013

BioMed Research International

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Obesity and the associated metabolic syndrome are among the most common and detrimental metabolic diseases of the modern era, affecting over 50% of the adult population in the United States. Surgeries designed to promote weight loss, known as bariatric surgery, typically involve a gastric bypass procedure and have shown high success rates for treating morbid obesity. However, following gastric bypass surgery, many patients develop chronic anemia, most commonly due to iron deficiency. Deficiencies of vitamins B1, B12, folate, A, K, D, and E and copper have also been reported after surgery. Copper deficiency can cause hematological abnormalities with or without neurological complications. Despite oral supplementation and normal serum concentrations of iron, copper, folate, and vitamin B12, some patients present with persistent anemia after surgery. The evaluation of hematologic disorders after gastric bypass surgery must take into account issues unique to the postsurgery setting that influence the development of anemia and other cytopenias. In this paper, the clinical characteristics and differential diagnosis of the hematological disorders associated with gastric bypass surgery are reviewed, and the underlying molecular mechanisms are discussed.

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“…An association with the sugars used in soft drinks has been reported in rats, 12 but a link has not been proved in humans. 13 Copper is necessary for the integrity of the red blood cell membrane, and as a caeruloplasmin component it is vital for oxidation and transport of ferrous iron, 14 hence the hypocaeruloplasminaemia and anaemia seen in our patients, and the abnormal results of iron studies and bone marrow findings in case 2. Neutropenia, and rarely pancytopenia, 15 as well as thrombocytosis, 16 have also been described, although the mechanisms remain unclear.…”

Section: Discussionmentioning

confidence: 87%