Anemia and Inflammation in ST-Segment Elevation Myocardial Infarction

Zhang, Enyuan; Che, Jingjin; Chen, Xin; Li, Guangping; Li, Zhenyu; Qin, Tian-Tian; Tong, Qing; Zhao, Weiwei

doi:10.1097/maj.0000000000000471

Cited by 13 publications

(14 citation statements)

References 27 publications

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“…Our results concur with a burgeoning evidence that baseline hemoglobin measurements improve the prognostic ability of the GRACE score with regards to in-hospital and 30-day mortality [31][32][33], death/MI within 6 months [34,35] or MACEs within 12 months [36]. None of these studies, however, are from a rural setting and have reported prevalence of baseline anemia to be <30%.…”

Section: Discussionsupporting

confidence: 88%

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India

Chiwhane

Burchundi

Manakshe

et al. 2020

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Background: Anemia is highly prevalent in low-and middle-income countries, where prevalence of acute coronary syndrome (ACS) is also rising. Evidence indicates that baseline anemia status can prognosticate ACS. However, the Global Registry of Acute Coronary Events (GRACE) score that is popularly used all over the world does not include information on anemia. Objectives: Our objective was to investigate if anemia at admission, along with the GRACE score, improves the prediction of adverse outcomes within 6 months in rural Indian patients of ACS. Methods: We enrolled 200 ACS patients at the Acharya Vinoba Bhave Rural Hospital-a rural, tertiary care hospital in central India. Patients were followed for 6 months for death and major adverse cardiac event (MACE). Improvement in the prediction of adverse events by including anemia in addition to the GRACE score was quantified using area under the receiver operating characteristic curve (AUC), integrated discrimination improvement (IDI) and the net reclassification index (NRI). Results: There were 31 deaths due to MACE and an additional 28 non-fatal MACE events during follow-up. Baseline hemoglobin was strongly and independently associated with both outcomes even after adjusting for a multivariable propensity score. For the outcome of death and death/MACE there was a moderate improvement in the AUC of 1% and 6%, respectively. However, for these outcomes the IDI for baseline hemoglobin was 6% (p = 0.03) and 12% (p << 0.0001), respectively, while the NRI was 0.50 (p = 0.01) and 0.78 (p << 0.0001), respectively. Conclusions: Inclusion of baseline anemia in addition to the GRACE score improves prognostication of ACS patients.

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Section: Discussionsupporting

confidence: 88%

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India

Chiwhane

Burchundi

Manakshe

et al. 2020

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“…In addition to thrombosis and platelet activation, a number of studies suggest that inflammatory response also plays an important role in the occurrence and progression of STEMI. [3–5]…”

Section: Introductionmentioning

confidence: 99%

Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Yang¹,

Dong²,

Lu³

et al. 2019

Medicine

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“…In addition, an increased NLR results in more vulnerable plaque and higher risk of thrombotic diseases . A follow‐up investigation of 248 patients who underwent primary percutaneous coronary intervention with ST‐segment elevation myocardial infarction reported that 36 patients experienced major adverse cardiovascular events . The authors concluded that higher NLR and lower hemoglobin independently predicted 1‐year major adverse cardiac events …”

Section: Introductionmentioning

confidence: 99%

The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension

Wang

Geng

et al. 2017

J of Clinical Hypertension

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Recently, neutrophil/lymphocyte ratio (NLR) has been proved to be a useful indicator of inflammation and cardiovascular risk. Brachial-ankle pulse wave velocity is an indicator for early atherosclerotic changes. It is unknown whether NLR differs in subtypes of hypertension, and little research has been performed on the relationship between NLR and arteriosclerosis in subtypes of hypertension. The purpose of this article was to investigate their relationship. A total of 217 consecutive patients with hypertension and 132 persons without hypertension were included. All hypertension patients were divided into three groups according to office blood pressure. Brachial-ankle pulse wave velocity was elevated in patients with isolated systolic hypertension, isolated diastolic hypertension, and systolic and diastolic hypertension compared with normotensive controls. NLR in patients with isolated systolic hypertension and systolic and diastolic hypertension were higher than in normotensive controls. Correlation analysis revealed a positive correlation between NLR and brachial-ankle pulse wave velocity.Multivariate linear regression analysis showed that NLR was an effective indicator for brachial-ankle pulse wave velocity.

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Anemia and Inflammation in ST-Segment Elevation Myocardial Infarction

Cited by 13 publications

References 27 publications

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India

Incremental Prognostic Value of Anemia in Acute Coronary Syndrome from A Rural Hospital in India

Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

The relationship between neutrophil to lymphocyte ratio and artery stiffness in subtypes of hypertension

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