Anemia: A Cause of Intolerance to Thyroxine Sodium

Shakir, K.M. Mohamed; Turton, David B.; Aprill, Brian S.; Drake, Almond J.; Eisold, Radm John F.

doi:10.1016/s0025-6196(11)64193-1

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Iron is a component of many enzymes including thyroid peroxidase (TPO) which takes part in the initial two steps in thyroid hormone biosynthesis [11]. Low ferritin levels have also been observed in hypothyroid patients [12]. Several studies in animals and humans have shown that nutritional iron deficiency may significantly lower the circulating levels of both thyroxine and triiodothyronine and may also reduce conversion of T4 to T3 [13,14].…”

Section: Discussion:-mentioning

confidence: 99%

AWARENESS AND CORRELATION BETWEEN SOME FACTORS SUCH AS IRON DEFICIENCY ANEMIA, OBESITY & HYPERLIPIDEMIA, IN HYPOTHYROIDISM PATIENTS IN HAIL, KINGDOM OF SAUDI ARABIA

Shahin¹,

Algrwan²,

Algriys³

2018

IJAR

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Section: Discussion:-mentioning

confidence: 99%

AWARENESS AND CORRELATION BETWEEN SOME FACTORS SUCH AS IRON DEFICIENCY ANEMIA, OBESITY & HYPERLIPIDEMIA, IN HYPOTHYROIDISM PATIENTS IN HAIL, KINGDOM OF SAUDI ARABIA

Shahin¹,

Algrwan²,

Algriys³

2018

IJAR

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“…3 was bypassed by giving the patient a different LT4 product. If problems continue, refer the patient to an allergist to rule out other causes [118] [119] [120].…”

Section: Failure Of Therapymentioning

confidence: 99%

Clinical Practice Recommendations for Assessment and Management of Hypothyroidism

Alsifri¹,

Aljuhani²,

Al‐Jedai³

et al. 2022

IJCM

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Hypothyroidism is a common disorder, potentially severe, often clinically ignored, easily diagnosed by laboratory tests, and highly treatable. It may cause chronic illnesses if left untreated. Saudi Society of Endocrinology and Metabolism (SSEM) assembled a panel of twelve endocrinologists with experience in thyroid diseases in adults and children and made up a task force. An initial concept proposal that included types of hypothyroidism, population, scope, and prevalence in Saudi Arabia was obtained. The proposal was divided into several topics discussed in February 2022. The panel approved that the consensus will include all types of hypothyroidism in Saudi Arabia, screening, diagnosis, management, and special population. A literature review was carried out. Most of the latest international guidelines were screened in Europe and USA. The literature search was completed in March 2022. They drafted a report that was distributed to the entire panel. Approval of the recommendations required consensus, defined as a majority approval. The recommendations were revised to accommodate any differences of opinion until a consensus was reached. Recommendations were finally formulated on April 2022.

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“…Additional iron substitution in subclinical hypothyroidism increases the effectiveness of L-thyroxine treatment. According to Shakir et al, in patients with anaemia the tolerance of L-thyroxine therapy may be worse [3]. Therefore, it is advised to initiate treatment with iron substitution, then add L-thyroxine.…”

Section: Hyperthyroidismmentioning

confidence: 99%

Changes in complete blood count parameters influenced by endocrine disorders

Szczepanek‐Parulska

Adamska

Korda

et al. 2021

Endokrynologia Polska

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Complete blood count is one of the most common diagnostic methods used in everyday practice. Hormonal status is known to affect blood count parameters. The aim of this study is to summarize changes in blood count that may indicate endocrine disorders, based on a literature review. Red cell parameters deteriorate in thyroid disorders including autoimmune thyroiditis and tend to resolve with appropriate treatment implementation. The most frequent form of anaemia associated with thyroid dysfunction is normocytic anaemia. Macrocytic anaemia is more typical of autoimmune thyroiditis-induced hypothyroidism, while microcytic anaemia is more common in hyperthyroidism. Unexplained anaemia or an increase in red cell distribution width should prompt the investigation of thyroid disorders. Cushing's disease may manifest as an increase in white blood cells and platelets. In the blood smear, neutrophilia is often present, while lymphocytes and eosinophils may be within the lower normal range. Hypercortisolism may induce both hyperaemia and anaemia. In hypopituitarism, a decrease in red blood cell count, haemoglobin, haematocrit, and platelets is observed. Acromegaly may be accompanied by an increase in mean corpuscular volume of erythrocytes. Testosterone deficiency is manifested by a decrease in red cell parameters, whereas hyperandrogenism may lead to polycythaemia. In polycystic ovary syndrome an increase in white blood cell count reflects an underlying inflammatory state. Complete blood count analysis is an easily available and cost-effective additional tool in the diagnosis and treatment monitoring of endocrine disorders.

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Anemia: A Cause of Intolerance to Thyroxine Sodium

Cited by 8 publications

References 8 publications

AWARENESS AND CORRELATION BETWEEN SOME FACTORS SUCH AS IRON DEFICIENCY ANEMIA, OBESITY & HYPERLIPIDEMIA, IN HYPOTHYROIDISM PATIENTS IN HAIL, KINGDOM OF SAUDI ARABIA

AWARENESS AND CORRELATION BETWEEN SOME FACTORS SUCH AS IRON DEFICIENCY ANEMIA, OBESITY & HYPERLIPIDEMIA, IN HYPOTHYROIDISM PATIENTS IN HAIL, KINGDOM OF SAUDI ARABIA

Clinical Practice Recommendations for Assessment and Management of Hypothyroidism

Changes in complete blood count parameters influenced by endocrine disorders

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