Anecdotes of lithogenesis and atherogenesis conversely liable for cardiac dysfunction and kidney stone formation

Devarajan, Asokan

doi:10.1007/s00240-015-0754-8

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…CVDs and nephrolithiasis are both among multifactorial cases, environmental interaction, and genetic factors. Reactive oxygen spices are the linking agents of nephrolithiasis and CVDs (-2) [65][66][67].…”

Section: Mechanisms Of Nephrolithiasismentioning

confidence: 99%

A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction

Karami,

Maleki,

Baghbeheshti

et al. 2019

GMJ

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The interaction between organs is a crucial part of modern medicine. As a very prerequisite to manage a disease, practitioners should have a full awareness of the related organs. Kidney and heart are two vital organs that are closely interconnected in various fields. These two organs have a lot of common risk factors for making a person unhealthy; therefore, if you prevent the disease in one of them, the otherâ€™s morbidity might be alleviated as well. Among them, nephrolithiasis and myocardial infarction (MI) have more risk factors in common, and both could be fatal. Also, these two diseases are important regarding the prevalence, incidence, and burden of disease. Some studies confirm the relationship between MI and nephrolithiasis; however, further researches are needed to discover the exact direction of their relationship. The present review aims to explain the mechanism of MI and nephrolithiasis; clarify the relationship between these two disease based on physiological, pathological, and clinical studies; and propose some solutions for the prevention and treatment of such diseases. [GMJ.2019;8:e1289]

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Section: Mechanisms Of Nephrolithiasismentioning

confidence: 99%

A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction

Karami,

Maleki,

Baghbeheshti

et al. 2019

GMJ

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“…Compelling data showed that kidney stones independently associated with a higher risk of cardiovascular diseases (CVDs), including coronary heart diseases (CHD) and stroke in large cohort studies and meta-analysis of cohort studies (1)(2)(3)(4)(5)(6). Kidney stones, also known as nephrolithiasis, was recognized as a systemic disorder and closely associated with many cardiometabolic diseases such as diabetes, obesity, hypertension, metabolic syndrome (MetS) (7)(8)(9) and chronic kidney disease (10). However, whether the dynamic changes in metabolic status possess effect on the association of kidney stones with the risk of CVDs remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events

Zhao

Shen

et al. 2022

Front. Cardiovasc. Med.

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BackgroundsWhether longitudinal changes in metabolic status influence the effect of kidney stones on cardiovascular disease (CVD) remains unclarified. We investigated the modification effect of status changes in metabolic syndrome (MetS) in the association of kidney stones with risk of incident CVD events.MethodsWe performed a prospective association and interaction study in a nationwide cohort including 129,172 participants aged ≥ 40 years without CVDs at baseline and followed up for an average of 3.8 years. Kidney stones information was collected by using a questionnaire and validated by medical records. The repeated biochemical measurements were performed to ascertain the metabolic status at both baseline and follow-up.Results4,017 incident total CVDs, 1,413 coronary heart diseases (CHDs) and 2,682 strokes were documented and ascertained during follow-up. Kidney stones presence was significantly associated with 44%, 70% and 31% higher risk of CVDs, CHDs and stroke, respectively. The stratified analysis showed significant associations were found in the incident and sustained MetS patients, while no significant associations were found in the non-MetS at both baseline and follow-up subjects or the MetS remission ones, especially in women. For the change status of each single component of the MetS, though the trends were not always the same, the associations with CVD were consistently significant in those with sustained metabolic disorders, except for the sustained high blood glucose group, while the associations were consistently significant in those with incident metabolic disorders except for the incident blood pressure group. We also found a significant association of kidney stone and CVD or CHD risk in the remain normal glucose or triglycerides groups; while the associations were consistently significant in those with incident metabolic disorders except for the incident blood pressure group. We also found a significant association of kidney stone and CVD or CHD risk in the remain normal glucose or triglycerides groups.ConclusionsA history of kidney stones in women with newly developed MetS or long-standing MetS associated with increased risk of CVD. The mechanisms link kidney stones and CVD risk in the metabolic and non-metabolic pathways were warranted for further studies.

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Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

Devarajan

2018

Clinical Science

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The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed a positive association between nephrolithiasis and CVDs. Based on preclinical and clinical evidences, this review discusses: (i) stone forming risk factors, crystal nucleation, aggregation, injury-induced crystal retention, and stone formation, (ii) CVD risk factors such as dyslipidemia, perturbation of gut microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described.

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Anecdotes of lithogenesis and atherogenesis conversely liable for cardiac dysfunction and kidney stone formation

Cited by 6 publications

References 3 publications

A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction

A Short Review on the Relationships Between Nephrolithiasis and Myocardial Infarction

Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events

Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases

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