Andrology: Clinical value of sperm morphology for in-vivo fertility: comparison between World Health Organization criteria of 1987 and 1992

Barratt, Christopher L.R.; M, Naeeni; Clements, Sarah; Id, Cooke

doi:10.1093/oxfordjournals.humrep.a135994

Cited by 32 publications

(18 citation statements)

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“…Several authors found these values to be of little or no clinical value [7,9,10] . These articles did, however, fi nd a positive correlation between the high proportion of morphologically normal sperms and the increased likelihood of fertility and/or pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is a positive correlation between normal semen parameters and male fertility potential, the threshold values for fertility/subfertility according to WHO criteria [1,2] are of little clinical value in discriminating between the fertile and the subfertile male [7][8][9][10][11] . If these criteria were applied, a great number of fertile males (partners having had pregnancies shortly before, after, or at the time of a spermiogram) were classifi ed as subfertile.…”

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confidence: 99%

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The Use of Semen Parameters to Identify the Subfertile Male in the General Population

Merwe

Kruger

Oehninger

et al. 2005

Gynecol Obstet Invest

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Aims: To present a structured review of the literature published on semen parameters and in vivo fertility potential and to establish fertility/subfertility thresholds for sperm morphology using Tygerberg strict criteria, sperm concentration, and sperm motility. Method: The published literature comparing fertile and subfertile populations between 1983 and 2002 was reviewed. Results: A total of 265 articles were identified by the sourcing methodology, but only four articles provided data that could be tabulated and analyzed. Using receiver-operating characteristics curves, morphology proved to be the best predictor of subfertility in 2 of the 4 articles, with concentration and motility also showing good predictive power. The thresholds calculated ranged between 4 and 10% for morphology, between 13.5 × 10⁶/ml and 34 × 10⁶/ml for concentration, and between 32 and 52% for motility. A second set of much lower thresholds was calculated in three of the articles using either a 15 or 50% prevalence of subfertility in the population or the tenth percentile of the fertile population. The adjusted thresholds were between 3 and 5% for morphology, between 9 × 10⁶/ml and 20 × 10⁶/ml for concentration, and between 20 and 30% for motility. Conclusions: Because these lower thresholds have a much higher positive predictive value, we suggest that thresholds of <5% normal sperm morphology, a concentration <15 × 10⁶/ml, and a motility <30% should be used to identify the subfertile male. The lower threshold for morphology also fits in vitro fertilization and intrauterine insemination data calculated previously. Using the parameters in combination increases the clinical value of semen analysis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Use of Semen Parameters to Identify the Subfertile Male in the General Population

Merwe

Kruger

Oehninger

et al. 2005

Gynecol Obstet Invest

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“…De plus, en r~ponse ~i I'~tude de Ducot et al [21], I'IAM devient le TZP (index de t6ratozo-ospermie) qui est la moyenne du nombre d'anomalies par spermatozo'ide anormal [33]. Barratt et al [3] ont compare la signification clinique de la morphologie des spermatozoides evalu~s par les crit6res de I'OMS de 1987 et de 1992. IIs ont conclu que I'~dition de 1992 n'apportait pas de changement majeur dans la valeur predictive de ce param~tre pour d6terminer la fertilit6 du patient.…”

Section: C) Classification De Romsunclassified

Sperm morphology examination

Saïdi

Gruel

Roset-Blessman

et al. 2008

Androl.

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Mots cl6s : infertitit6, morphologie, spermatozoi'de, t6ratozoospermie I. INTRODUCTION L'exarnen du sperme (sperrnogramme -spermocytogramme) constitue une des ~tapes clefs dans rexploration du couple infertile. /'~jaculat normal contient des spermatozoi'des pr~sentant des variations importantes de la taille et de la forme de la t~te, de I'acrosome, de la pi(bce interm~diaire et du flagelle. Cette h6terog~n6it~ s'explique par le fait que le sperrnatozd[de, ceUule hautement diff~renci~e, est le r~sultat ultime d'un processus complexe : la spermatogen~se. Ce processus peut ~tre la cible de facteurs toxiques endog~nes ou exog~nes qui peuvent induire la production excessive de spermatozoides morphologiquement anormaux responsable d'une t~ratozoospermie. Une morphologie anormale des spermatozofdes peut comprornettre le pouvoir f6condant d'un sperme. Cependant, le profil morphologique du sperrne semble ~tre le param~tre sperrnatique le plus constant chez un homme [12,19,30,36].La morphologie du sperme a et~ reconnue comme le meilleur facteur pr~dictif de la fertilit~ naturelle ou de I'issue en inseminations intra ut~rines (IIU) ou en f6condation in vitro (FIV) classique [8,38]. Cependant, la majoritd des auteurs n'ont pas retrouv6 de relation entre la morphologie du sperrne et le succ~s de I'ICSI [20,36,31]. Quatre explications ont ~t~ propos~es. Premi~rement, une morphologie normale du spermatozoi'de est requise pour le passage des barri~res ovocytaires qui sont court-circuit~es par I'ICSI. Deuxi~mement, les spermatozdfdes portant des anomalies morphologiques ~videntes ne sont pas retenus pour rinjection. Troisi~mement, le spermocytogramme r~alis~ sur des ceUules randomisees de I'~jaculat n'est pas le reflet exact de la qualit6 du spermatozoi"de inject6. Quatri~mement, les Correspondance :Pr Nathalie RIVES -Laboratoire de Biologie de la I rue de Germont, CHU H6pitaux de Rouen, 76031, 158 anomalies ultrastructurales qui sont les seules associees au devenir de I'ICSI ne peuvent pas (~tre d~tect~es ni au grossissement xl00, ni au grossissement x200-400 [4,6]. L'analyse morphologique du sperme ou spermocytogramme est une dtude descriptive de la forme des spermatozofdes partir d'un ~chantillon repr6sentatif d'un 6jaculat. La morphologie n'est qu'un des param~tres qualitatifs de la spermatogen~se. Cette analyse est d~pendante des techniques d'imagerie utilisdes et des criteres d'interprdtation adopt6s pour ddfinir un spermatozo'ide morphologiquement normal. II. MICROSCOPIE OPTIQUEC'est la mdthode la plus utilisde et elle fait partie des examens de routine du fait de son faible coot et de sa simplicitY. L'analyse morphologique des spermatozoi'des est faite partir de preparations fixdes et colordes examinees en lumi~re transmise au grossissement final xl000 (objectif 100 immersion). Mdthodes de colorationPlusieurs colorations sont possibles : Giemsa, coloration de Papanicolaou modifiee pour les spermatozoides (PAP), coloration de Bruyan-Leishman ou encore coloration de SchorT. D'apr~s certains auteurs, la coloration de...

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“…Although these criteria have been updated three times, many investigators still considered some of the values, such as the percentage of normal morphology, inappropriate [8][9][10] . A cutoff point of 30% on normal morphology was considered overly strict and 10-20% appeared to be more appropriate [8,11,12] .…”

Section: Introductionmentioning

confidence: 99%

Reference Values of Semen Parameters for Healthy Chinese Men

Gao

Gao²,

Walker³

et al. 2008

Urol Int

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Aims: To establish reference values of semen parameters in a residential, geographic, and age representative sample of healthy Chinese men. Methods: From a national study of 1,191 healthy Chinese men, semen samples were analyzed from 105 subjects whose wives or partners were pregnant within the 12 months prior to the date when the semen sample was taken. Results: The means, fifth percentiles, and percentages lower than the WHO criteria for semen parameters were, respectively: 75.8 × 10⁶/ml, 17.8 × 10⁶/ml, and 6.7% for sperm concentration; 206.9 × 10⁶/ejection, 26.3 × 10⁶/ejection, and 6.7% for total sperm count; 18.9, 3.0, and 79.1% for rapid progressive motility; 49.1, 25.3, and 52.4% for sperm progressive motility; 73.8, 49.3, and 45.7% for sperm viability, and 49.5, 25.2, and 9.5% for normal morphology. Conclusion: The values of semen parameters for Chinese men are lower than the WHO criteria, especially for rapid progressive motility, progressive motility, and sperm viability, and a different standard for Chinese may be needed.

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Andrology: Clinical value of sperm morphology for in-vivo fertility: comparison between World Health Organization criteria of 1987 and 1992

Cited by 32 publications

References 0 publications

The Use of Semen Parameters to Identify the Subfertile Male in the General Population

The Use of Semen Parameters to Identify the Subfertile Male in the General Population

Sperm morphology examination

Reference Values of Semen Parameters for Healthy Chinese Men

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