Andrological aspects of testicular cancer

Berthelsen, Jens

doi:10.1111/j.1365-2605.1984.tb00804.x

Cited by 15 publications

(9 citation statements)

References 52 publications

(33 reference statements)

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“…The finding that spermatogenesis was significantly worse as a consequence of pretreatment with GnRH analogs-which had induced a partial hypogonadal state at the time of Cis-Pt treatment-may be important since it is now well-recognized that men with malignant disease often have some degree of gonadal dysfunction prior to institution of any oncological therapy (Schilsky et al, 1980;Berthelsen, 1984). Such men attending for potential cryostorage of semen frequently have abnormalities of testicular exocrine and endocrine function (Hendry et al, 1983;Handelsman, Boylan & Conway, 1986).…”

Section: Discussionmentioning

confidence: 99%

Effects of gonadotropin‐releasing hormone analogs on cis‐platinum‐induced spermatogenic damage

et al. 1988

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In order to test the hypothesis that pretreatment with gonadotropin-releasing hormone (GnRH) analogs might ameliorate cytotoxic drug-induced testicular damage, mature male Wistar rats were pretreated for 2 weeks with a GnRH superactive agonist or a pure GnRH antagonist prior to, and for 1 week after, a 5 mg/kg intraperitoneal dose of cis-platinum. Despite inhibition of testicular function by both GnRH analogs prior to cis-platinum administration, there was no evidence of protection or enhanced recovery of spermatogenesis at 6 and 12 weeks after cis-platinum treatment, and spermatogenesis was significantly further depressed at both time-points by both GnRH agonist and antagonist pretreatment. This suggests that pretreatment with GnRH analogs in the rat does not protect spermatogenesis from cis-platinum-induced testicular damage within up to two spermatogenic cycles and that hypogonadism at the time of cytotoxic drug treatments may aggravate testicular damage.

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Section: Discussionmentioning

confidence: 99%

Effects of gonadotropin‐releasing hormone analogs on cis‐platinum‐induced spermatogenic damage

et al. 1988

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“…Our previous studies on the common precursor cell, carcinoma in situ (CIS), suggested that aetiological factors would operate during development of the primordial germ cell in foetal testes . Early studies by Berthelsen (1984) demonstrated that the contralateral testis in patients with testis cancer often showed signs of malfunction both with regard to spermatogenesis and hormone production. Both ipsilateral and contralateral testes had frequently impaired spermatogenesis, such as Sertoli cell-only pattern, spermatogenic arrest, microcalcifications, seminiferous tubule atrophy or tubules with CIS.…”

Section: Increasing Rates and Evidence For A Developmental Origin Of mentioning

confidence: 99%

Is human fecundity declining?

et al. 2006

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Summary The decreasing trends in fertility rates in many industrialized countries are now so dramatic that they deserve much more scientific attention. Although social and behavioural factors undoubtedly play a major role for these trends, it seems premature, and not based on solid information, to conclude that these trends can be ascribed to social and behavioural changes alone. There is evidence to suspect that changing lifestyle and increasing environmental exposures, e.g. to endocrine disrupters, are behind the trends in occurrence of male reproductive health problems, including testis cancer, undescended testis and poor semen quality. These biological factors may also contribute to the extremely low fertility rates. However, the necessary research is complex and requires non-traditional collaboration between demographers, epidemiologists, clinicians, biologists, wild life researchers, geneticists and molecular biologists. This research effort can hardly be carried out without major support from governments and granting agencies making it possible to fund collaborative projects within novel research networks of scientists.

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“…An association between testicular cancer and semen quality is now firmly established. The preinvasive stage of carcinoma in situ of testis which leads to testicular germ cell cancer was first described in infertile men (Skakkebaek, 1972) and Berthelsen detected reduced spermatogenesis in testicles contralateral to testicular cancer, prior to treatment (Berthelsen & Skakkebaek, 1983;Berthelsen, 1984). More recently, this finding has been corroborated by comparing the semen quality of men with unilateral testis cancer to men with non-testicular malignancies: the semen quality of men with unilateral testicular cancer was lower than expected compared to men with only one functioning testis (Petersen et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern

et al. 2006

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For many years it has been acknowledged that Danish and Norwegian men have one of the highest risks in the world for testicular cancer in sharp contrast to neighbouring Baltic men from Finland, Estonia and Lithuania. As an association between poor semen quality and testicular cancer has been established, it was suggested that men from high-risk testicular cancer areas would be more likely to have poor semen quality. However, previous studies were not able to elucidate this question due to their retrospective nature. In prospectively designed and strictly controlled studies of fertile men, the existence of regional differences in semen quality was confirmed. In addition, studies of men from the general populations were undertaken and a similar regional difference in semen quality was detected. Men from the eastern part of the Nordic-Baltic area had better semen quality than men from the western part. These findings parallel the incidence of testicular cancer in these regions. Approximately 20% of young men from Norway and Denmark had sperm concentrations below the World Health Organization reference level of 20 x 10(6) spermatozoa/mL, and approximately 40% had <40 x 10(6) spermatozoa/mL which, according to recent publications, may be the 'threshold' below which fecundity declines. In Denmark, the situation is of concern and a continued surveillance of semen quality in young men was established in 2001 by a government-supported programme.

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Andrological aspects of testicular cancer

Cited by 15 publications

References 52 publications

Effects of gonadotropin‐releasing hormone analogs on cis‐platinum‐induced spermatogenic damage

Effects of gonadotropin‐releasing hormone analogs on cis‐platinum‐induced spermatogenic damage

Is human fecundity declining?

Coordinated European investigations of semen quality: results from studies of Scandinavian young men is a matter of concern

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