Andrographolide-Soya-L-α-Phosphatidyl Choline Complex Augmented Solubility and Drug Delivery in Leishmania donovani, a Causative Agent for Cutaneous and Visceral Leishmaniasis

Pingle, Purva; Mourya, Atul; Namdeo, Madhulika; Babu, Katta Chanti; Veerabomma, Harithasree; Maurya, Radheshyam; Singh, Pankaj Kumar; Mehra, Neelesh Kumar; Srivastava, Saurabh; Madan, Jitender

doi:10.1208/s12249-023-02507-w

Cited by 3 publications

(2 citation statements)

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“…However, ADG is known to have low solubility in water (74 μg/mL), which limits its therapeutic use because of low bioavailability when administered orally . Andrographolide’s bioavailability, the proportion of a drug that reaches the systemic circulation in its active form, has been found to range from 1 to 2%. , As a result, a variety of methods have been studied to increase this bioavailability, as well as improve the solubility of ADG in water. − …”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Carbon-Based Quantum Dots and Doped Derivatives for Improved Andrographolide’s Hydrophilicity in Drug Delivery Platforms

Medina-Berríos,

Pantoja-Romero,

Lavín Flores

et al. 2024

ACS Omega

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Carbon-based quantum dots (CBQDs), sulfurdoped carbon-based quantum dots (S-CBQDs), and nitrogendoped carbon-based quantum dots (N-CBQDs) have strong potential for drug delivery platforms. They were conjugated with andrographolide, a well-known hydrophobic drug, to study the concomitant changes in hydrophilicity. The interactions between these nanomaterials and the drug were studied by characterizing the optical and structural properties of the nanoparticles before and after coupling with the drug. It was found that the interaction of the drug with these nanomaterials produced noticeable changes in their optical and structural properties. Moreover, the partition coefficient for the nanocomposites was determined by NMR. The results indicate that conjugating the drug with the nanoparticles significantly enhanced its affinity for the aqueous phase, from 2.632 to 0.1117, thereby opening the possibility of using this approach for developing an effective drug delivery platform for this hydrophobic drug.

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Section: Introductionmentioning

confidence: 99%

“… 6 , 7 As a result, a variety of methods have been studied to increase this bioavailability, as well as improve the solubility of ADG in water. 8 − 10 …”

Section: Introductionmentioning

confidence: 99%