Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells

Chu, Haihan

doi:10.3892/ol.2018.7941

Cited by 18 publications

(27 citation statements)

References 36 publications

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“…Numerous pharmacological studies have demonstrated feasibility of targeting TLR4 in melanoma using small molecule modulators of natural and synthetic origin. The natural product andrographolide has been shown to block melanoma tumor growth in a murine model by inactivating the TLR4‐NF‐κB signaling axis . Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the downregulation of TLR4 .…”

Section: Tlr4 In Melanomamentioning

confidence: 99%

“…Numerous specialized reviews have recently provided comprehensive coverage of TLR4 pharmacology . Much emphasis has centered on natural products with TLR4‐antagonistic activity including promiscuous multitarget agents, such as baicalin, curcumin, sulforaphane, andrographolide, and glycyrrhizin, often derived from phytochemical dietary sources that seem amenable to chemopreventive repurposing . Moreover, a number of potent and selective TLR4 antagonists of synthetic origin have been identified and have now entered preclinical and clinical assessment .…”

Section: Tlr4 In Merkel Cell Carcinomamentioning

confidence: 99%

“…The natural product andrographolide has been shown to block melanoma tumor growth in a murine model by inactivating the TLR4-NF-κB signaling axis. 66,67 Tea polyphenols inhibit the proliferation, migration, and invasion of melanoma cells through the downregulation of TLR4. 68 Inhibition of p38 and ERK1/2 pathways by the TLR2 and TLR4-antagonistic natural product and xanthone derivative sparstolonin B has been shown to suppress LPSdriven inflammation-induced melanoma metastasis in a B16 mouse model.…”

Section: Tlrin Melanomamentioning

confidence: 99%

“…[75][76][77] Much emphasis has centered on natural products with TLR4-antagonistic activity including promiscuous multitarget agents, such as baicalin, curcumin, sulforaphane, andrographolide, and glycyrrhizin, often derived from phytochemical dietary sources that seem amenable to chemopreventive repurposing. 11,17,66,67 Moreover, a number of potent and selective TLR4 antagonists of synthetic origin have been identified and have now entered preclinical and clinical assessment. 31,32,77,78 Of note, TLR4-directed antagonism can also be achieved targeting direct downstream effectors, such as the MyD88-directed small molecule ST-2825.…”

Section: Tlr4-directed Molecular Interventions and Clinical Translamentioning

confidence: 99%

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TLR4 in skin cancer: From molecular mechanisms to clinical interventions

Dickinson

Wondrak

2019

Molecular Carcinogenesis

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The health and economic burden imposed by skin cancer is substantial, creating an urgent need for the development of improved molecular strategies for its prevention and treatment. Cutaneous exposure to solar ultraviolet (UV) radiation is a causative factor in skin carcinogenesis, and TLR4‐dependent inflammatory dysregulation is an emerging key mechanism underlying detrimental effects of acute and chronic UV exposure. Direct and indirect TLR4 activation, upstream of inflammatory signaling, is elicited by a variety of stimuli, including pathogen‐associated molecular patterns (such as lipopolysaccharide) and damage‐associated molecular patterns (such as HMGB1) that are formed upon exposure to environmental stressors, such as solar UV. TLR4 involvement has now been implicated in major types of skin malignancies, including nonmelanoma skin cancer, melanoma and Merkel cell carcinoma. Targeted molecular interventions that positively or negatively modulate TLR4 signaling have shown promise in translational, preclinical, and clinical investigations that may benefit skin cancer patients in the near future.

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Section: Tlr4 In Melanomamentioning

confidence: 99%

Section: Tlr4 In Merkel Cell Carcinomamentioning

confidence: 99%

Section: Tlrin Melanomamentioning

confidence: 99%

Section: Tlr4-directed Molecular Interventions and Clinical Translamentioning

confidence: 99%

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TLR4 in skin cancer: From molecular mechanisms to clinical interventions

Dickinson

Wondrak

2019

Molecular Carcinogenesis

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“…Interestingly, most of these dietary botanicals function by targeting multiple cancer-associated pathways to exert anti-tumorigenic effects on cancer progression (11). Andrographolide is a C20 diterpenoid lactone, which is an active ingredient derived from the traditional Chinese herbal medicine Andrographis paniculate (12)(13)(14). Because of its ability to circulate in the bloodstream (15)(16)(17), Andrographis…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects of Andrographis via ferroptosis‑associated genes in gastric cancer

et al. 2021

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The overall prognosis of advanced/metastatic gastric cancer (GC) remains poor despite the development of pharmacotherapy. Therefore, other treatment options, such as complementary and alternative medicine, should be considered to overcome this aggressive malignancy. Andrographis, which is a generally unharmful botanical compound, has gained increasing interest for its anticancer effects in multiple malignancies via the regulation of cancer progression-associated signaling pathways. In the present study, a series of in vitro experiments (cell proliferation, colony formation and apoptosis assays) was designed to elucidate the antitumor potential and mechanism of Andrographis in GC cells. The present study demonstrated that Andrographis exerted antitumor effects in GC cell lines (MKN74 and NUGC4) by inhibiting proliferation, reducing colony formation and enhancing apoptotic activity. Furthermore, it was demonstrated that the expression levels of the ferroptosis-associated genes heme oxygenase-1, glutamate-cysteine ligase catalytic and glutamate-cysteine ligase modifier were significantly upregulated after Andrographis treatment in both GC cell lines in reverse transcription-quantitative PCR experiments (P<0.05); this finding was further confirmed by immunoblotting assays (P<0.05). In conclusion, to the best of our knowledge, the present study was the first to demonstrate that Andrographis possessed antitumor properties by altering the expression levels of ferroptosis-associated genes, thereby providing novel insights into the potential of Andrographis as an adjunctive treatment option for patients with metastatic GC.

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Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Zeng

Wei

Zhou

et al. 2021

Phytotherapy Research

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Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and fever, sore throat, sore tongue, snake bite with its excellent functions of clearing heat and toxin, cooling blood and detumescence from times immemorial. Modern pharmacological research corroborates that andrographolide, the major ingredient in this traditional herb, is the fundamental material basis for its efficacy. As the main component of Andrographis paniculata (Burm. f.) Wall. ex Nees, andrographolide reveals numerous therapeutic actions, such as antiinflammatory, antioxidant, anticancer, antimicrobial, antihyperglycemic and so on. However, there are scarcely systematic summaries on the specific mechanism of disease treatment and pharmacokinetics. Moreover, it is also found that it possesses easily ignored security issues in clinical application, such as nephrotoxicity and reproductive toxicity. Thereby it should be kept a lookout over in clinical. Besides, the relationship between the efficacy and security issues of andrographolide should be investigated and evaluated scientifically. In this review, special emphasis is given to andrographolide, a multifunctional natural terpenoids, including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches. A brief overview of its clinical trials is also presented. This review intends to systematically and comprehensively summarize the current researches of andrographolide, which is of great significance for the development of andrographolide clinical products. Noteworthy, those un‐cracked issues such as specific pharmacological mechanisms, security issues, as well as the bottleneck in clinical transformation, which detailed exploration and excavation are still not to be ignored before achieving integration into clinical practice. In addition, given that current extensive clinical data do not have sufficient rigor and documented details, more high‐quality investigations in this field are needed to validate the efficacy and/or safety of many herbal products.

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Andrographolide inhibits proliferation and induces cell cycle arrest and apoptosis in human melanoma cells

Cited by 18 publications

References 36 publications

TLR4 in skin cancer: From molecular mechanisms to clinical interventions

TLR4 in skin cancer: From molecular mechanisms to clinical interventions

Antitumor effects of Andrographis via ferroptosis‑associated genes in gastric cancer

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

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