Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells

A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo

“…In other studies, androgarpholide alone can inhibit proliferation of breast cancer cells and non-small cell lung cancer (NSCLC) cells by downregulating the PI3K/Akt pathway (22,23). NSCLC cells also can be suppressed by androgarpholide through the HIF-1α pathway (24). In the β-TC-6 (human insulinoma cell line), androgarpholide suppress growth of cancer cells through inhibition of the TLR4/NF-κB signaling pathway in intro and in vivo (25).…”

Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling

“…Inhibition of hypoxia-induced RA-FLS invasion by celastrol is mediated through attenuation of the HIF-1α/ CXCR4 signaling pathway [30]. Andrographolide has been shown to downregulate HIF-1α in human non-small cell lung cancer A549 cells [20]. To investigate the effects of andrographolide on HIF-1α, the expression of HIF-1α was assessed in andrographolide-treated RA-FLSs under hypoxic conditions.…”

“…Previous studies revealed that andrographolide protects hypoxiainduced oxidative/nitrosative brain injury in mice [19] and downregulates HIF-1α in human non-small cell lung cancer A549 cells [20]. Considering the important role of hypoxia in the pathogenesis of RA, it would be interesting to investigate the effects of andrographolide on hypoxia-induced pathological changes.…”

A novel semi-synthetic andrographolide analogue A5 inhibits tumor angiogenesis via blocking the VEGFR2-p38/ERK1/2 signal pathway

“…(16)(17)(18)(19). Meanwhile, there are reports that andrographolide also inhibits angiogenesis via regulating matrix metalloproteinase (MMP)-2/9 and hypoxia-inducible factor-1α, which contributes to its antitumor activity (20,21).…”