Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling

Zhang, Xinfang; Ding, Mingjing; Cheng, Chen; Zhang, Yi; Xiang, Shui-Ying; Lu, Jing; Liu, Zi-Bing

doi:10.1016/j.intimp.2020.106230

Cited by 26 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As an extremely interesting multitarget diterpenoid lactones, in recent years, andrographolide has attracted considerable number of interests in the medicinal chemistry society with its potential multiple pharmacological activities such as antiinflammatory (Ding et al, 2017), antioxidant (Mussard et al, 2019; Zhang et al, 2020), anticancer (Farooqi et al, 2020; Sato et al, 2018; Zhang et al, 2017), antimicrobial (Gupta, Mishra, & Ganju, 2017; Panraksa, Ramphan, Khongwichit, & Smith, 2017; Shi et al, 2020; Srivastava, Garg, Srivastava, & Seth, 2021), antihyperglycemic (Su et al, 2020) and regulating blood lipid (Lin et al, 2018), immunoregulation (Zhang, Yang, Du, & Guo, 2020), improving memory impairment (Das, Mishra, Ganju, & Singh, 2017), as well as mitigating cartilage damage (Chen, Luo, & Chen, 2020) and so on (Figure 2). In view of the increasing awareness of the side effects of chemotherapy drugs, this medicinal ingredient may serve as one of the backbones for the treatment of related diseases in the future.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Zeng

Wei

Zhou

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and fever, sore throat, sore tongue, snake bite with its excellent functions of clearing heat and toxin, cooling blood and detumescence from times immemorial. Modern pharmacological research corroborates that andrographolide, the major ingredient in this traditional herb, is the fundamental material basis for its efficacy. As the main component of Andrographis paniculata (Burm. f.) Wall. ex Nees, andrographolide reveals numerous therapeutic actions, such as antiinflammatory, antioxidant, anticancer, antimicrobial, antihyperglycemic and so on. However, there are scarcely systematic summaries on the specific mechanism of disease treatment and pharmacokinetics. Moreover, it is also found that it possesses easily ignored security issues in clinical application, such as nephrotoxicity and reproductive toxicity. Thereby it should be kept a lookout over in clinical. Besides, the relationship between the efficacy and security issues of andrographolide should be investigated and evaluated scientifically. In this review, special emphasis is given to andrographolide, a multifunctional natural terpenoids, including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches. A brief overview of its clinical trials is also presented. This review intends to systematically and comprehensively summarize the current researches of andrographolide, which is of great significance for the development of andrographolide clinical products. Noteworthy, those un‐cracked issues such as specific pharmacological mechanisms, security issues, as well as the bottleneck in clinical transformation, which detailed exploration and excavation are still not to be ignored before achieving integration into clinical practice. In addition, given that current extensive clinical data do not have sufficient rigor and documented details, more high‐quality investigations in this field are needed to validate the efficacy and/or safety of many herbal products.

show abstract

Section: Introductionmentioning

confidence: 99%

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Zeng

Wei

Zhou

et al. 2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Further studies [14][15][16] have found that the regulation of cell senescence by ERK is achieved by activating the transcription factor CEBPB. On the one hand, the activation of CEBPB can break the balance between oxidation and antioxidation [17,18]; and on the other hand, CEBPB can also regulate the secretion of SASP [4,19]. Although there is currently no evidence that arsenic can participate in the occurrence of skin cell senescence through the ERK/CEBPB signaling pathway, arsenic can activate the ERK signaling pathway which has been accepted by several studies [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…Extracellular-regulated protein kinases (ERK) are one of the members of MAPK, including two members, ERK1 and ERK2, which mainly mediate cell proliferation, migration, differentiation, and apoptosis [ 13 ]. In cellular senescence, limited studies [ 14 – 16 ] show that ERK phosphorylation can regulate the expression of downstream transcription factor CEBPB, and the activation of CEBPB can break the balance between oxidation and antioxidation, thereby inducing oxidative stress [ 17 , 18 ]. Furthermore, the activation of CEBPB can coordinate with nuclear factor κ B to regulate the secretion of multiple SASP components [ 19 ], including inflammatory factors (interleukin-1 α (IL-1 α ), interleukin-6 (IL-6), interleukin-8 (IL-8), and transforming growth factor β (TGF- β )), matrix remodeling factors (matrix metallopeptidase-1 (MMP-1), matrix metallopeptidase-3 (MMP-3)), and growth factors (epidermal growth factor (EGF), vascular endothelial growth factor (VEGF)).…”

Section: Introductionmentioning

confidence: 99%

Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence

Zeng

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Chronic exposure to inorganic arsenic is a major environmental public health issue worldwide affecting more than 220 million of people. Previous studies have shown the correlation between arsenic poisoning and cellular senescence; however, knowledge regarding the mechanism and effective prevention measures has not been fully studied. First, the associations among the ERK/CEBPB signaling pathway, oxidative stress, and arsenic-induced skin cell senescence were confirmed using the HaCaT cell model. In the arsenic-exposed group, the relative mRNA and protein expressions of ERK/CEBPB signaling pathway indicators (ERK1, ERK2, and CEBPB), cell cycle-related genes (p21, p16INK4a), and the secretion of SASP (IL-1α, IL-6, IL-8, TGF-β1, MMP-1, MMP-3, EGF, and VEGF) and the lipid peroxidation product (MDA) were significantly increased in cells ( P < 0.05 ), while the activity of antioxidant enzyme (SOD, GSH-Px, and CAT) was significantly decreased ( P < 0.05 ), and an increased number of cells accumulated in the G1 phase ( P < 0.05 ). Further Kaji-ichigoside F1 intervention experiments showed that compared to that in the arsenic-exposed group, the expression level of the activity of antioxidant enzyme was significantly increased in the Kaji-ichigoside F1 intervention group ( P < 0.05 ), but the indicators of ERK/CEBPB signaling pathway, cell cycle-related genes, and SASP were significantly decreased ( P < 0.05 ), and the cell cycle arrest relieved to a certain extent ( P < 0.05 ). Our study provides some limited evidence that the ERK/CEBPB signaling pathway is involved in low-dose arsenic-induced skin cell senescence, through regulating oxidative stress. The second major finding was that Kaji-ichigoside F1 can downregulate the ERK/CEBPB signaling pathway and regulate the balance between oxidation and antioxidation, alleviating arsenic-induced skin cell senescence. This study provides experimental evidence for further understanding of Kaji-ichigoside F1, a natural medicinal plant that may be more effective in preventing and controlling arsenic poisoning.

show abstract

“…In addition, it was also stated that Andrographis paniculata has an anti-inflammatory effect through the inactivation of NF-B, where Andrographolide can activate PP2A. [20] PP2A dephosphorylates p65 Ser(536), which can reduce translocation of NF-kB and reduce NF-kB binding. In the process of atherosclerosis, NF-B is the main pathway activated by increased expression of TLR4, which can further lead to increased cytokines and chemokines involved in the inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

Effects of Andrographis paniculata Extract on Toll-Like Receptor-4 (TLR4) Expression and Aorta Calcification in Rats Exposed to Cigarette Smoke

2021

View full text Add to dashboard Cite

Introduction: Smoking has been associated with morbidity and cardiovascular events. Administration of antioxidants can prevent aortic calcification and reduce levels of atherosclerosis markers caused by cigarette exposure. Andrographis paniculata, with the main ingredient of Andrographolide, has antioxidant, anti-inflammatory and effects on the cardiovascular system. Methods: This study is an experimental study with a randomized post-test control group design to determine the effect of Andrographis paniculata extract on aortic abnormalities in rats. Samples were randomly divided into two groups: the control group, which was given standard feed and exposure to cigarette smoke, and the treatment group, which was given standard feed, exposure to cigarette smoke, and Andrographis paniculata extract. Results: TLR4 expression in the control group (mean 41.50 ± 4.17), the first treatment group (mean 30.75 ± 3.24), the second group (mean 15.25 ± 3.01), the third group (mean 9.75 ± 4.65). The Shapiro Wilk normality test showed that the data were normally distributed (P > 0.05) with homogeneous data variance (P > 0.05). The analysis was continued with One Way Anova and found a significant difference between groups (P = 0.000). The aortic calcification in control group (mean 1.80 ± 0.616 pixel percentage); group 1 (means1.00 ± 0.48 pixel percentage), group 2 (mean 0.54 ± 0.34 pixel percentage), group 3 (mean 0.24 ± 0.16). In the Shapiro Wilk normality test, all data of aortic calcifications were normally distributed (P > 0.05) with inhomogeneous data variance (P < 0.05). The analysis continued with One Way Anova, and there were significant differences between groups (P = 0.001). Conclusion: Giving Andrographis paniculata extract to rats exposed to cigarette smoke decreased TLR4 expression and reduce the incidence of aortic calcification. Keywords: Andrographis paniculata, calcification, TLR4.

show abstract

Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling

Cited by 26 publications

References 39 publications

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Assessing the Potential Value and Mechanism of Kaji-Ichigoside F1 on Arsenite-Induced Skin Cell Senescence

Effects of Andrographis paniculata Extract on Toll-Like Receptor-4 (TLR4) Expression and Aorta Calcification in Rats Exposed to Cigarette Smoke

Contact Info

Product

Resources

About