Andrographolide as a potent and promising antiviral agent

Reshi, Latif; Wang, Chi-Yong

doi:10.1016/s1875-5364(20)60016-4

Cited by 21 publications

(20 citation statements)

References 93 publications

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“…Nowadays, diseases related to microbial infection are an increasing issue in most parts of the world and, are becoming more and more imminent for individuals. In recent years, the antimicrobial effects of andrographolide on viruses (Enmozhi, Raja, Sebastine, & Joseph, 2021; Jiang et al, 2021; Latif & Wang, 2020), bacteria (Zhang et al, 2020) and parasites (Ibraheem et al, 2019) have been broadly reported. With the assist of systems biology, researchers promulgated that andrographolide has strong interaction with COVID‐19 related target proteins through regulating chemokine signaling, Rap1 signaling, cytokine‐cytokine receptor interaction, MAPK signaling and so on, concurrently exhibited different immune‐regulatory effects (Khanal et al, 2021).…”

Section: Pharmacologymentioning

confidence: 99%

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Zeng

Wei

Zhou

et al. 2021

Phytotherapy Research

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Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and fever, sore throat, sore tongue, snake bite with its excellent functions of clearing heat and toxin, cooling blood and detumescence from times immemorial. Modern pharmacological research corroborates that andrographolide, the major ingredient in this traditional herb, is the fundamental material basis for its efficacy. As the main component of Andrographis paniculata (Burm. f.) Wall. ex Nees, andrographolide reveals numerous therapeutic actions, such as antiinflammatory, antioxidant, anticancer, antimicrobial, antihyperglycemic and so on. However, there are scarcely systematic summaries on the specific mechanism of disease treatment and pharmacokinetics. Moreover, it is also found that it possesses easily ignored security issues in clinical application, such as nephrotoxicity and reproductive toxicity. Thereby it should be kept a lookout over in clinical. Besides, the relationship between the efficacy and security issues of andrographolide should be investigated and evaluated scientifically. In this review, special emphasis is given to andrographolide, a multifunctional natural terpenoids, including its pharmacology, pharmacokinetics, toxicity and pharmaceutical researches. A brief overview of its clinical trials is also presented. This review intends to systematically and comprehensively summarize the current researches of andrographolide, which is of great significance for the development of andrographolide clinical products. Noteworthy, those un‐cracked issues such as specific pharmacological mechanisms, security issues, as well as the bottleneck in clinical transformation, which detailed exploration and excavation are still not to be ignored before achieving integration into clinical practice. In addition, given that current extensive clinical data do not have sufficient rigor and documented details, more high‐quality investigations in this field are needed to validate the efficacy and/or safety of many herbal products.

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Section: Pharmacologymentioning

confidence: 99%

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Zeng

Wei

Zhou

et al. 2021

Phytotherapy Research

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“…Andrographolide and its derivatives represent effective agents for the prevention and treatment of viral diseases (Hossain, Urbi, Sule, & Rahman, 2014;Latif & Wang, 2020). There is a possibility that most of the studies discussed in the present review article have not been performed in accordance to a recent consensus document providing a perspective in best practice in pharmacological research on bioactive preparations from plants (Izzo et al, 2020).…”

Section: Antiviral Activities Of Andrographolide and Its Derivativesmentioning

confidence: 99%

Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties

Jadhav

Karuppayil

2021

Phytotherapy Research

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Andrographis paniculata is home to a rich variety of molecules especially andrographolide and its derivatives. Clinical properties of the andrographolide are multifarious and include: analgesic, antipyretic, antiretroviral, antiproliferative, antimalarial, antithrombotic, antihyperglycemic, antiurolethial, antilesihmaniasis, hepatoprotective, immune-modulatory, protective against alcohol induced toxicity and cardioproetcive activity and anticancer activity. Andrographolide, neoandrographolide, dehydroandrographolide and several natural and synthetic derivatives of it: 14-deoxy-11,12-didehydroandrographolide and 14-deoxyandrographolide, dehydroandrographolide succinic acid monoester (DAMS), 14-ά-lipoyl andrographolide (AL-1), 14-acetyl-3,9-isopropyl-ideneandrographolide, 14-acetylandrographolide, 3,14,19-triacetylandrographolide, and 3,9-isopropyl-idene andrographolide, are shown to possess significant antiviral activity against HIV, influenza A, HBV, HCV, HPP and HSV. Studies on SARS CoV 2 is restricted to in silico molecular docking studies on viral targets and selected host target proteins. The main targets of andrographolide and its derivatives are fusion and adsorption of virus to the host cell, binding to viral receptor and co-receptor, enzymes involved in DNA/RNA/ Genome replication by the virus, translation, post-translation and reverse transcription.Andrographolide as a drug is yet to reach its full therapeutic potential since this molecule shows low bioavailability. Andrographolide therapy is in need of an appropriate delivery system that may increase its bioavailability. Further high-quality studies are needed to firmly establish the clinical efficacy of the plant.

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“…Investigating the drug delivery systems of these phytoconstituents of A. paniculata has become a popular research topic recently. Several papers have reviewed the antiviral activity of andrographolide and its derivatives (see, for example, the work of Gupta et al [21], Jiang et al [3], and Reshi and Yong [27]. However, discussing the antiviral activities of andrographolide and its derivatives, combined with the delivery system of andrographolide, is a more interesting topic.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System

Adiguna

Panggabean

Atikana³

et al. 2021

Pharmaceuticals

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Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of A. paniculata exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems.

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Andrographolide as a potent and promising antiviral agent

Cited by 21 publications

References 93 publications

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties

Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System

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